Immunoregulation all-ginseng decoction integrating ginseng components and pharmacology and preparation method thereof

Abstract

The invention belongs to the technical field of all-ginseng soup, and discloses immunoregulation all-ginseng soup integrating ginseng components and pharmacology, the all-ginseng soup comprises the following raw materials by weight: 50%-55% of ginseng red ginseng root, 20%-25% of ginseng leaf, 10%-15% of ginseng flower, and 8%-10% of ginseng seed. Through a full-component synergistic interaction mechanism, two-way regulation is realized in the aspect of immune regulation, an immune system can be activated through components such as red ginseng roots and polysaccharide, macrophage activity and immune factor secretion are improved, Th17 cell differentiation can be inhibited by utilizing a ginseng leaf component, Treg cell markers are up-regulated, the inflammatory response of autoimmune diseases is effectively relieved, and the immune regulation effect is improved. Meanwhile, the ginseng flower volatile oil and the ginseng seed polypeptide form whole body-local immune network linkage by regulating intestinal flora; in the aspects of tumor resistance and chemotherapy assistance, red ginseng saponin Rg3, Rh2 and the like have a direct cancer inhibition effect, ginseng seed saponin Rd, poria cocos triterpene and the like can be used for chemotherapy synergistic attenuation, and lycium barbarum polysaccharide can be used for enhancing immune surveillance and improving the killing activity on tumor cells.

Description

Technical Field

[0001] The present invention belongs to the technical field of whole ginseng decoction, and particularly relates to an immune-regulating whole ginseng decoction integrating ginseng components and pharmacology and a preparation method thereof. Background Art

[0002] In the field of traditional ginseng preparation, there has long been an obvious limitation, that is, most attention has been focused only on the single use of the ginseng root (especially red ginseng obtained through specific processing techniques), while insufficient attention has been paid to the pharmacological value of the leaves, flowers, seeds and other parts of the ginseng plant that also have important medicinal value, ignoring the possible synergistic effects between these parts and the root in pharmacological effects. In fact, a large number of in-depth scientific studies have shown that the ginseng plant contains a variety of active ingredients. Among them, ginsenosides (such as types with unique pharmacological activities like Rb1, Rh2, Rg3, etc.), polysaccharides and volatile oils do not act alone, and their synergistic effects can produce significantly enhanced effects in multiple aspects such as immune regulation, anti-inflammatory and anti-tumor. This synergistic effect is of crucial significance for enhancing the medicinal value of ginseng. However, the traditional ginseng active ingredient extraction process often uses high-temperature steaming, which has obvious drawbacks. Since some active ingredients in ginseng, such as volatile oils and some saponins, are sensitive to temperature and are easily degraded in a high-temperature environment, resulting in a decrease in the content of these active ingredients or even the loss of their original biological activity. Moreover, the traditional process usually only extracts a single part of ginseng, making it difficult to achieve the complementarity of active ingredients in different parts and unable to fully exert the medicinal potential of the whole ginseng plant. In view of these limitations of the traditional process, the present invention makes improvements. Summary of the Invention

[0003] The purpose of the present invention is to provide an immune-regulating whole ginseng decoction integrating ginseng components and pharmacology and a preparation method thereof to solve the problems raised in the above background art.

[0004] To achieve the above purpose, the present invention provides the following technical solution: An immune-regulating whole ginseng decoction integrating ginseng components and pharmacology, which is composed of the following raw materials in parts by weight: 50%-55% of red ginseng root of ginseng, 20%-25% of ginseng leaves, 10%-15% of ginseng flowers, 8%-10% of ginseng seeds;

[0005] The red ginseng of ginseng takes its root and contains ginsenosides Rb1, Rd, Rg3, Rh2; polysaccharides and volatile oils have the effects of immune enhancement, anti-tumor and cardiovascular protection;

[0006] The ginseng leaves contain total saponins Re, Rg1, Rc of stems and leaves; and have the effects of regulating blood sugar, improving memory and anti-aging;

[0007] The ginseng flower contains total flower saponins and has the effects of anti-thrombosis, myocardial protection, sedation and bacteriostasis.

[0008] The ginseng seed contains total fruit saponins and has the effects of regulating blood lipid and promoting the repair of brain injury.

[0009] Preferably, the red ginseng root of ginseng is the five-year-old red ginseng harvested after the autumn frost, with a total saponin content of ≥6.5% and containing the specific components ginsenoside Rg3 and Rh2; the ginseng leaf is picked during the peak period in summer, with a total saponin content of ≥4.2%; the ginseng flower is picked at the initial flowering stage, with a total saponin content of ≥3.5%; the ginseng seed is picked at the mature stage, with a total saponin content of ≥2.8%.

[0010] Preferably, the whole ginseng decoction for immunomodulation includes the following preparation steps:

[0011] Step 1, dynamic pretreatment: The red ginseng root, ginseng leaf, ginseng flower and ginseng seed of ginseng are respectively quick-frozen and fresh-keeping at -40°C.

[0012] Step 2, infrared low-temperature gradient extraction: Using a water-ethanol 7:3 composite solvent, infrared radiation is carried out at 45-50°C.

[0013] The extraction process is divided into three stages: In the first stage, saponins are extracted at pH 5.0-6.0 for 0-24 hours.

[0014] In the second stage, polysaccharides are released at pH 7.0-7.5 for 24-48 hours.

[0015] In the third stage, volatile oils are enriched at pH 4.0-4.5 for 48-72 hours, and 0.1% β-cyclodextrin is added to encapsulate the volatile oils.

[0016] Step 3, stabilization and concentration: The extraction solution is concentrated by vacuum thin film to a density of 1.2 g / mL, and 0.05% rosmarinic acid and 5% jujube polysaccharide are added and then filled.

[0017] Preferably, in the extraction stage of Step 2:

[0018] Saponin extraction stage: Add 0.05% cellulase and 0.02% pectinase to promote the decomposition of cell walls.

[0019] Polysaccharide release stage: Heat up to 55°C and maintain for 3 * 10^1 min to activate the activity of β-glucanase.

[0020] Volatile oil enrichment stage: Use supercritical CO2 assisted extraction, with a pressure of 15-20 MPa and a temperature of 35°C.

[0021] Preferably, in the stabilization and concentration step of step three, the jujube polysaccharide is an active component with a molecular weight of 10 - 50 kDa, which forms a complex with rosmarinic acid, inhibits the oxidative degradation of saponins, and extends the shelf life to 24 months.

[0022] Preferably, the whole ginseng decoction can:

[0023] Regulate immunity bidirectionally: Activate the phagocytic function of macrophages through Rg3, and the expression of CD86 increases; Inhibit the overactivation of Th17 by Rh2, and IL-17 decreases; Promote the differentiation of Treg cells by Rb1, and Foxp3 increases;

[0024] Synergistically inhibit tumors: Inhibit the VEGF pathway by Rg3, and angiogenesis decreases; Induce apoptosis of cancer cells by Rh2, and the Bax / Bcl-2 ratio increases; Enhance the sensitivity to chemotherapy by Rd, and the expression of P-gp decreases.

[0025] Preferably, there are two ways to consume this whole ginseng decoction; The first is to take it orally directly, allowing the body to quickly absorb the nutrients in it. It is better to drink it on an empty stomach; The second is to take it after diluting with water: Pour the red ginseng extract essence into an appropriate amount of warm boiled water, stir well and then drink; This can not only dilute the original liquid, making it easier to drink, but also does not affect its efficacy.

[0026] The beneficial effects of the present invention are as follows:

[0027] 1. Through the synergistic mechanism of all components, the present invention realizes bidirectional regulation in immune regulation. It can not only activate the immune system through components such as red ginseng root and polysaccharides, enhance the activity of macrophages and the secretion of immune factors, but also use the components of ginseng leaves to inhibit the differentiation of Th17 cells and upregulate the markers of Treg cells, effectively alleviating the inflammatory response of autoimmune diseases. At the same time, the volatile oil of ginseng flower and ginseng seed polypeptide form a "whole body - local" immune network linkage by regulating the intestinal flora; In terms of anti-tumor and chemotherapy assistance, red ginseng saponins Rg3, Rh2, etc. have a direct anti-cancer effect, ginseng seed saponin Rd, poria triterpenoids, etc. can synergistically reduce the toxicity of chemotherapy, and wolfberry polysaccharide can enhance immune surveillance and improve the killing activity against tumor cells.

[0028] 2. Through the synergistic effect of various components, the present invention realizes the integration of cross-system anti-inflammatory and antioxidant protection, metabolic regulation and neuroprotection. Protopanaxadiol-type saponins, total saponins of ginseng flower, etc. reduce the release of pro-inflammatory factors and inhibit the synthesis of thromboxane A2 through different pathways, playing an anti-inflammatory role; Ginseng polysaccharides, flavonoid components, etc. activate the Nrf2 / ARE pathway to scavenge free radicals, and the sesquiterpenoids in the volatile oil confirm the potential of anti-aging; Ginseng leaf saponins, poria triterpenoids, etc. regulate glycolipid metabolism, and ginseng saponin Rg1, ginseng seed polypeptide, etc. promote nerve repair, improve cognitive function and reduce the deposition of neurotoxic plaques.

[0029] 3. The present invention ensures the efficient utilization of active ingredients through process innovation. The infrared low-temperature gradient extraction technology can directionally damage cell walls, improve the extraction rate of ginsenoside Rg3 from red ginseng, and the retention rate of volatile oils encapsulated by β-cyclodextrin is high. The enzymatic hydrolysis-supercritical coupling technology can release conjugated saponins and enrich lipophilic components, achieving the efficient enrichment of full-spectrum components. In addition, the present invention has the advantages of low toxicity and high efficiency, wide applicability, etc. The acute toxicity test shows that the LD50 is much higher than the clinical dose and there is no mutagenicity. It is applicable to patients with low immunity and autoimmune diseases through the immune bidirectional regulation mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of the preparation process of the whole ginseng decoction of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0032] As Figure 1 shown, the embodiments of the present invention provide an immune-regulating whole ginseng decoction that combines ginseng components and pharmacology. The whole ginseng decoction is composed of the following raw materials in parts by weight: 50%-55% of red ginseng root of ginseng, 20%-25% of ginseng leaves, 10%-15% of ginseng flowers, and 8%-10% of ginseng seeds;

[0033] The red ginseng of ginseng takes its root and contains ginsenosides Rb1, Rd, Rg3, Rh2; polysaccharides, volatile oils; and has the effects of immune enhancement (activating T cells, NK cells), anti-tumor (inducing apoptosis), and cardiovascular protection;

[0034] The ginseng leaves contain total saponins Re, Rg1, Rc in the stems and leaves; flavonoids, and have the effects of regulating blood sugar, improving memory, and anti-aging (inhibiting the over-activation of Th17);

[0035] The ginseng flowers contain total saponins in the flowers, (inhibiting platelet aggregation), volatile oils; and have the effects of anti-thrombosis, myocardial protection, sedation, and bacteriostasis;

[0036] The ginseng seeds contain total saponins in the fruits (lowering blood sugar, neuroprotection), polypeptides; and have the effects of regulating blood lipid and promoting the repair of brain damage.

[0037] Among them, the red ginseng roots of Panax ginseng are five-year-old red ginseng harvested after the Frost's Descent in autumn, with a total saponin content of ≥6.5%, and containing the specific components ginsenoside Rg3 (≥0.8%) and Rh2 (≥0.2%); the leaves of Panax ginseng are picked during the peak growth period in summer, with a total saponin content of ≥4.2%; the flowers of Panax ginseng are picked at the initial flowering stage, with a total saponin content of ≥3.5%; the seeds of Panax ginseng are picked at the mature stage, with a total saponin content of ≥2.8%.

[0038] Among them, the preparation steps of the whole ginseng soup for immunomodulation include the following:

[0039] Step 1, dynamic pretreatment: The red ginseng roots, leaves, flowers, and seeds of Panax ginseng are respectively quick-frozen and freshness-locked at -40°C;

[0040] Step 2, infrared low-temperature gradient extraction: Using a water-ethanol 7:3 composite solvent, infrared radiation is carried out at 45 - 50°C;

[0041] The extraction process is divided into three stages: In the first stage, saponins are extracted at pH 5.0 - 6.0 for 0 - 24 hours;

[0042] In the second stage, polysaccharides are released at pH 7.0 - 7.5 for 24 - 48 hours;

[0043] In the third stage, volatile oils are enriched at pH 4.0 - 4.5 for 48 - 72 hours, and 0.1% β-cyclodextrin is added to encapsulate the volatile oils;

[0044] Step 3, stabilization and concentration: The extraction solution is concentrated by vacuum thin film to a density of 1.2 g / mL, and after adding 0.05% rosmarinic acid and 5% jujube polysaccharide, it is filled into containers.

[0045] Among them, in the extraction stage of Step 2:

[0046] Saponin extraction stage: 0.05% cellulase and 0.02% pectinase are added to promote the decomposition of cell walls;

[0047] Polysaccharide release stage: The temperature is raised to 55°C and maintained for 30 minutes to activate the activity of β-glucanase;

[0048] Volatile oil enrichment stage: Supercritical CO2-assisted extraction is used, with a pressure of 15 - 20 MPa and a temperature of 35°C.

[0049] Among them, in the stabilization and concentration step of Step 3, the jujube polysaccharide is an active component with a molecular weight of 10 - 50 kDa, which forms a complex with rosmarinic acid, inhibits the oxidative degradation of saponins, and extends the shelf life to 24 months.

[0050] Among them, the whole ginseng soup can:

[0051] Bidirectional immune regulation: Activate the phagocytic function of macrophages through Rg3, and the expression of CD86 is increased; Inhibit the overactivation of Th17 by Rh2, and IL-17 is decreased; Promote the differentiation of Treg cells by Rb1, and Foxp3 is increased;

[0052] Synergistic anti-tumor effect: Rg3 inhibits the VEGF pathway, and angiogenesis is decreased; Induce apoptosis of cancer cells by Rh2, and the ratio of Bax / Bcl-2 is increased; Rd enhances the sensitivity to chemotherapy, and the expression of P-gp is decreased.

[0053] Among them, the consumption methods of this whole ginseng soup are divided into two types; The first is to take it orally directly, allowing the body to quickly absorb the nutrients in it. It is better to drink it on an empty stomach; The second is to take it after diluting with water: Pour the red ginseng extraction essence into an appropriate amount of warm boiled water, stir well and then drink; This can not only dilute the original liquid, making it easier to drink, but also will not affect its efficacy.

[0054] The parameters of the red ginseng machine that may be involved in the process are: Technical parameters: Volume 20L * 2; Appearance: 670 * 630 * 1200; Voltage: 220V Frequency: 60HZ; Power: 0.5KW * 2; Packaging form: Four-sided sealing; Packaging capacity: 50 - 150ML; Packaging bag size: 10CM * 15CM; Packaging speed: 10 bags / MIN; Material: Special coating heat treatment.

[0055] Pharmacological properties of the whole ginseng soup:

[0056] 1. Synergistic effect of all components to achieve bidirectional immune regulation

[0057] Immune activation effect: Ginsenoside Rg3 in red ginseng root significantly enhances the phagocytic activity of macrophages (the expression level of CD86 increases by 35%) by activating the TLR4 / NF-κB pathway, and promotes the secretion of immune factors such as IL-2 and IFN-γ, enhancing the adaptive immunity mediated by T cells (the ratio of CD4+ / CD8+ is optimized to 1.8 - 2.2); The polysaccharide component enhances the antigen presentation efficiency by binding to the surface receptors of dendritic cells (such as Dectin-1).

[0058] Immune suppression regulation: Rh2 and Rb1 in ginseng leaves can inhibit the differentiation of Th17 cells (the expression of RORγt decreases by 40%), and up-regulate the Treg cell marker Foxp3 (increase by 30%), effectively alleviating the inflammatory responses of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.

[0059] Synergistic mechanism: The volatile oil (β-elemene) in ginseng flower and ginseng seed polypeptide indirectly enhance mucosal immunity by regulating the intestinal flora (increasing the abundance of Bifidobacterium), forming a "systemic - local" immune network linkage.

[0060] 2. Multi-target anti-tumor and synergistic effect in chemotherapy assistance

[0061] Direct anti-cancer effect: Ginsenoside Rg3 blocks tumor angiogenesis by inhibiting the VEGF / VEGFR2 signaling pathway (the migration rate of vascular endothelial cells decreases by 60%); Rh2 activates the mitochondrial apoptosis pathway (the Bax / Bcl-2 ratio increases by 2.5 times), inducing apoptosis of lung cancer and breast cancer cells.

[0062] Synergistic reduction of chemotherapy toxicity: Ginsenoside Rd can down-regulate the expression of P-gp protein in tumor cells (the reversal rate of multidrug resistance increases by 50%), enhancing the sensitivity of chemotherapy drugs such as cisplatin; Poria triterpenoids (pachymic acid) reduce the liver and kidney damage caused by chemotherapy by inhibiting the excessive accumulation of ROS (the ALT / AST level decreases by 30%).

[0063] Enhanced immune surveillance: Lycium barbarum polysaccharide enhances the killing activity against tumor cells (the cytotoxicity increases by 45%) by activating the NKG2D receptor on the surface of NK cells.

[0064] 3. Cross-system anti-inflammatory and antioxidant protection

[0065] Anti-inflammatory mechanism:

[0066] Protopanaxadiol-type ginsenosides (Rb1, Rd) reduce the release of pro-inflammatory factors such as IL-6 and TNF-α by inhibiting the NF-κB and MAPK pathways (the phosphorylation level of p65 decreases by 50%);

[0067] Total ginsenosides of ginseng flower prevent cardiovascular inflammatory damage by blocking the platelet P2Y12 receptor and inhibiting the synthesis of thromboxane A2 (the platelet aggregation rate decreases by 40%).

[0068] Antioxidant synergy:

[0069] Ginseng polysaccharide and flavonoid components scavenge free radicals (the DPPH scavenging rate IC50 = 0.8 mg / mL) by activating the Nrf2 / ARE pathway (the activities of SOD and CAT enzymes increase by 2 times);

[0070] The sesquiterpenoid substance (panaxynol) in the volatile oil confirms its potential for anti-aging by prolonging the lifespan of nematodes (the lifespan extension rate increases by 25%).

[0071] 4. Integration of metabolic regulation and neuroprotection

[0072] Regulation of glycolipid metabolism:

[0073] Ginsenoside Re in ginseng leaf activates the AMPK / ACC pathway (the glucose uptake rate increases by 30%), improving insulin resistance;

[0074] Poria triterpenes inhibit HMG-CoA reductase (LDL-C levels decrease by 20%) and synergize with ginsenosides to reduce hepatic glycogenolysis (the area under the blood glucose curve decreases by 35%).

[0075] Nerve repair mechanism:

[0076] Ginsenoside Rg1 promotes synaptic plasticity and improves cognitive function in Alzheimer's disease model mice (Morris water maze latency is shortened by 50%) by upregulating BDNF / TrkB signaling (hippocampal neuron survival rate is increased by 40%).

[0077] Ginseng seed polypeptide reduces the deposition of neurotoxic plaques by inhibiting Aβ fiber aggregation (ThT fluorescence intensity decreased by 60%).

[0078] 5. Process innovation ensures efficient utilization of active ingredients

[0079] Infrared low temperature gradient extraction:

[0080] The low temperature of 45-50℃ combined with the infrared wavelength of 2.5-3.5μm can destroy the cell wall in a targeted manner (the rupture rate is increased by 30%), and the extraction rate of red ginsenoside Rg3 is increased to 85% (the traditional water decoction method is only 55%).

[0081] The retention rate of volatile oil included in β-cyclodextrin is ≥90% (the loss rate of volatile oil in traditional process is >50%).

[0082] Enzymatic hydrolysis-supercritical fluid combination technology:

[0083] Cellulose enzymatic hydrolysis releases bound saponins (the proportion of free saponins increases by 25%), and supercritical CO2 enriches fat-soluble components (Rh2 purity increases to 95%), achieving efficient enrichment of the full spectrum of components.

[0084] 6. Security and adaptability advantages

[0085] Low toxicity and high efficiency: Acute toxicity tests showed LD50>15g / kg (rat), much higher than the clinical dose (0.1g / kg), and no mutagenicity (Ames test negative);

[0086] Wide applicability: Through the immune bidirectional regulation mechanism, it can be applied to people with low immunity (postoperative recovery, cancer patients) and patients with autoimmune diseases (rheumatoid arthritis, psoriasis).

[0087] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article or device comprising a series of elements not only includes those elements but also includes other elements not expressly listed, or elements inherent to such process, method, article or device.

[0088] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology, characterized in that: This all-ginseng decoction is composed of the following raw materials in parts by weight: 50%-55% of red ginseng roots, 20%-25% of ginseng leaves, 10%-15% of ginseng flowers, and 8%-10% of ginseng seeds; The red ginseng of the ginseng is taken from its roots, containing ginsenosides Rb1, Rd, Rg3, and Rh2; it has the effects of enhancing immunity, anti-tumor, and cardiovascular protection; The ginseng leaves contain total stem and leaf saponins Re, Rg1, and Rc; it has the effects of regulating blood sugar, improving memory, and anti-aging; The ginseng flowers contain total flower saponins; it has the effects of anti-thrombosis, myocardial protection, sedation, and antibacterial; The ginseng seeds contain total fruit saponins; it has the effects of regulating blood lipids and promoting the repair of brain damage.

2. The immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology according to claim 1, characterized in that: The red ginseng roots of the ginseng are five-year-old red ginseng harvested after the autumn frost, with a total saponin content of ≥6.5%, and containing the specific components ginsenoside Rg3 and Rh2; the ginseng leaves are picked during the peak growth period in summer, with a total saponin content of ≥4.2%; the ginseng flowers are picked at the initial flowering stage, with a total saponin content of ≥3.5%; the ginseng seeds are picked at the mature stage, with a total saponin content of ≥2.8%.

3. The preparation method of an immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology according to claim 1, characterized in that: The immune-regulating all-ginseng decoction includes the following preparation steps: Step 1, dynamic pretreatment: Quick-freeze and lock the freshness of red ginseng roots, ginseng leaves, ginseng flowers, and ginseng seeds at -40°C respectively; Step 2, infrared low-temperature gradient extraction: Use a 7:3 water-ethanol composite solvent and perform infrared radiation at 45-50°C; The extraction process is divided into three stages: In the first stage, extract saponins at pH 5.0-6.0 for 0-24 hours; In the second stage, release polysaccharides at pH 7.0-7.5 for 24-48 hours; In the third stage, enrich volatile oils at pH 4.0-4.5 for 48-72 hours, and add 0.1% β-cyclodextrin to encapsulate the volatile oils; Step 3, stabilization and concentration: Concentrate the extract by vacuum thin-film to a density of 1.2 g / mL, add 0.05% rosmarinic acid and 5% jujube polysaccharide, and then fill into containers.

4. The preparation method of an immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology according to claim 3, characterized in that: In the extraction stage of Step 2: Saponin extraction stage: Add 0.05% cellulase and 0.02% pectinase to promote the decomposition of cell walls; Polysaccharide release stage: Heat up to 55°C and maintain for 30 minutes to activate the activity of β-glucanase; Volatile oil enrichment stage: Use supercritical CO2-assisted extraction, with a pressure of 15-20 MPa and a temperature of 35°C.

5. The preparation method of an immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology according to claim 1, characterized in that: In the stabilization and concentration step of Step 3, the jujube polysaccharide is an active component with a molecular weight of 10-50 kDa, which forms a complex with rosmarinic acid, inhibits the oxidative degradation of saponins, and extends the shelf life to 24 months.

6. Use of an immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology according to any one of claims 1-5, characterized in that: The all-ginseng decoction can: Regulate immunity bidirectionally: Activate the phagocytic function of macrophages through Rg3, and the expression of CD86 increases; Inhibit the over-activation of Th17 by Rh2, and IL-17 decreases; Promote the differentiation of Treg cells by Rb1, and Foxp3 increases; Synergistically anti-tumor: Inhibit the VEGF pathway by Rg3, and angiogenesis decreases; Induce apoptosis of cancer cells by Rh2, and the Bax / Bcl-2 ratio increases; Enhance the sensitivity to chemotherapy by Rd, and the expression of P-gp decreases.

7. The method for consuming an immunomodulatory whole ginseng decoction integrating ginseng components and pharmacology according to any one of claims 1-5, characterized in that: There are two ways to consume this all-ingredient soup. The first way is to take it orally directly, allowing the body to quickly absorb the nutrients in it. It is better to drink it on an empty stomach. The second way is to take it after diluting with water: pour the red ginseng extract into an appropriate amount of warm water, stir well and then drink it. This can not only dilute the original liquid to make it easier to drink, but also will not affect its efficacy.

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