Traditional Chinese medicine composition for treating qi-blood deficiency type fatigue and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating qi-blood deficiency type fatigue and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: codonopsis pilosula, salvia miltiorrhiza, schisandra chinensis, radix ophiopogonis, red ginseng, rhizoma polygonati, astragalus membranaceus, spina date seed and honey-fried licorice root. Comprising the following steps: preparing radix ginseng rubra and rhizoma polygonati into medicinal powder, infiltrating with ethanol, putting into a percolator, adding ethanol to immerse the medicinal powder, percolating by taking ethanol as a solvent, filtering and collecting filtrate; mixing codonopsis pilosula, salvia miltiorrhiza, schisandra chinensis, radix ophiopogonis, astragalus membranaceus, spina date seed and honey-fried licorice root with medicine powder residues left after percolation, adding water for soaking, decocting twice, combining medicine liquid, concentrating, adding ethanol, filtering and collecting filtrate; and mixing all the filtrates, and heating to remove ethanol. The traditional Chinese medicine composition has the effects of invigorating qi and blood, nourishing yin and generating body fluid, warming and tonifying heart and spleen, and refreshing mind and restoring consciousness, is used for treating qi and blood deficiency, qi and yang deficiency, palpitation and shortness of breath, fatigue and fatigue, and neurasthenia type fatigue, and has the advantages of definite curative effect, small side effect and low price.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition related to the treatment of qi and blood deficiency type fatigue. Background Art

[0002] In the theoretical system of traditional Chinese medicine, "deficiency of both qi and blood, and deficiency of both qi and yang" is a common syndrome name, also known as qi and blood deficiency. This disease is mainly manifested in the state of deficiency of qi and blood. Its formation is mostly due to long-term illness, which causes damage to both qi and blood. Qi and blood play a vital role in the physiological function of the human body. Qi is the leader of blood, and blood is the mother of qi. The two are interdependent and mutually nourishing, and jointly maintain the normal physiological activities of the human body. When both qi and blood are deficient, the human body will show a series of pathological manifestations, which can be specifically divided into two aspects: qi deficiency and blood deficiency. When qi is deficient, the human body lacks power, which manifests as physical fatigue, shortness of breath, laziness, and mental depression; blood deficiency leads to a decrease in nourishing ability. Insufficient blood makes the face pale and dull, the complexion is not good, and various parts of the body are not adequately nourished, resulting in a sense of weakness. These symptoms not only seriously affect the quality of life of patients, but may also further cause other diseases, posing a threat to human health.

[0003] In the field of Western medicine, the symptoms corresponding to Qi and blood deficiency (insufficient Qi and blood) are usually manifested as malnutrition, fatigue, drowsiness or neurasthenia. In response to these symptoms, Western medicine currently mainly uses enteral nutrition and vitamin supplements to treat them. Enteral nutrition is intended to provide patients with necessary nutrients to improve malnutrition; vitamin supplements are intended to maintain normal physiological metabolic functions of the human body.

[0004] However, these Western medical treatments have many adverse reactions. Gastrointestinal reactions may occur during the use of enteral nutrition solutions, such as nausea, vomiting, abdominal pain, bloating, diarrhea, etc. These symptoms will not only cause physical discomfort to the patient, but may also affect the patient's tolerance and absorption of the nutrition solution. In addition, enteral nutrition solutions may also cause metabolic disorders, electrolyte imbalances, blood sugar fluctuations and other problems, further increasing the burden on the patient's body. At the same time, the increased risk of infection is also a problem that cannot be ignored, such as aspiration pneumonia, which seriously threatens the patient's health. In addition, enteral nutrition solutions may also cause abnormal liver function and affect the normal function of the liver.

[0005] Although vitamin supplementation can help improve the nutritional status of patients to a certain extent, it also has adverse reactions. Common ones include gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, etc., which affect the patient's diet and digestive function. Some patients may also experience allergic reactions, which may even be life-threatening in severe cases. Moreover, excessive intake of vitamins may cause poisoning and cause damage to the body.

[0006] In view of the limitations of Western medicine in treating qi and blood deficiency (insufficient qi and blood), people have begun to re-examine the unique advantages of traditional Chinese medicine in this field. Traditional Chinese medicine has a long history and rich experience in treating qi and blood deficiency (insufficient qi and blood). Its treatment concept emphasizes the overall concept and syndrome differentiation and treatment. By adjusting the body's yin-yang balance and qi and blood circulation, the treatment purpose can be achieved. Compared with Western medicine, the treatment methods of traditional Chinese medicine are milder and more natural, which can fundamentally improve the patient's constitution and enhance the body's self-repair ability.

[0007] At present, although there are some traditional Chinese medicine drugs or methods for treating qi and blood deficiency (insufficient qi and blood) in the market, there is still a lack of a treatment means and drug with more exact curative effect and less side effects. The existing traditional Chinese medicine drugs may have problems such as complex components and unstable curative effects. Some treatment methods may also be difficult to promote due to cumbersome operations. Therefore, developing a drug or method for treating qi and blood deficiency (insufficient qi and blood) based on traditional Chinese medicine theory, with significant curative effect and less side effects, has important practical significance, which can meet the needs of the majority of patients for safe and effective treatment means and provide new options for the treatment of qi and blood deficiency (insufficient qi and blood). Summary of the Invention

[0008] The present invention provides a traditional Chinese medicine composition for treating qi and blood deficiency type fatigue and its preparation method. The traditional Chinese medicine composition has the effects of tonifying qi and blood, nourishing yin and promoting fluid production, warming and tonifying the heart and spleen, and refreshing the mind. It is used to treat qi and blood deficiency, qi and yang deficiency, palpitation and shortness of breath, fatigue and lethargy, and neurasthenia type fatigue. Its curative effect is exact, the side effects are small, and the price is cheap.

[0009] In order to solve the above technical problems, one of the technical solutions adopted by the present invention is to provide a traditional Chinese medicine composition for treating qi and blood deficiency type fatigue: It is prepared from the following raw materials: Codonopsis pilosula, Salvia miltiorrhiza, Schisandra chinensis, Ophiopogon japonicus, Red Ginseng, Polygonatum sibiricum, Astragalus membranaceus, Ziziphus jujuba var. spinosa, Honey-fried Licorice Root.

[0010] In the above technical solution, a more specific technical solution is: the weight parts of each raw material are as follows: 2 parts - 6 parts of Codonopsis pilosula, 3 parts - 7 parts of Salvia miltiorrhiza, 1 part - 4 parts of Schisandra chinensis, 2 parts - 6 parts of Ophiopogon japonicus, 1 part - 3 parts of Red Ginseng, 1 part - 3 parts of Polygonatum sibiricum, 3 parts - 6 parts of Astragalus membranaceus, 2 parts - 4 parts of Ziziphus jujuba var. spinosa, 1 part - 3 parts of Honey-fried Licorice Root.

[0011] Furthermore, the traditional Chinese medicine composition for treating qi and blood deficiency type fatigue is made into an oral liquid preparation for oral administration.

[0012] The second technical solution adopted by the present invention is to provide a preparation method of the above traditional Chinese medicine composition for treating qi and blood deficiency type fatigue. The preparation method includes the following preparation steps: Step 1: Make Red Ginseng and Polygonatum sibiricum in the above raw material herbs into medicinal powders; Step 2: Moisten the prepared medicinal powder with ethanol; Step 3: Place the moistened medicinal powder in a percolator; Step 4: Add ethanol to submerge the medicinal powder in the percolator and continue to soak; Step 5: After the soaking is completed, use ethanol as the solvent and perform percolation at a rate of 3 ml•min-1•kg-1; Step 6: Let the percolated medicinal liquid stand, filter it, collect the filtrate, and reserve it for use; Step 7: Mix the remaining raw medicinal materials, Codonopsis pilosula, Salvia miltiorrhiza, Schisandra chinensis, Ophiopogon japonicus, Astragalus membranaceus, Ziziphus jujuba var. spinosa, and honey-fried licorice, with the medicinal powder residue remaining after percolation in Step 6, and soak them in water; Step 8: Heat and decoct the soaked medicinal materials in Step 7 twice, and collect and combine the decocted medicinal liquids; Step 9: Concentrate the medicinal liquid obtained in Step 8 to obtain a concentrated liquid; Step 10: Add ethanol to the concentrated liquid obtained by concentrating in Step 9, stir, let it stand, filter, and collect the filtrate; Step 11: Mix the filtrate obtained by filtering in Step 6 with the filtrate obtained by filtering in Step 10, and then heat to remove ethanol.

[0013] In the above technical solution, a more specific technical solution is: It further includes the following steps: Step 12: Add sucrose to the filtrate after removing ethanol in Step 11, and then fill and sterilize it.

[0014] Among them, the Codonopsis pilosula in the present invention is the dried root of Codonopsis pilosula, Codonopsis pilosula var. modesta, or Codonopsis tangshen in the genus Codonopsis of the family Campanulaceae. It has a sweet taste and a neutral nature, and belongs to the spleen and lung meridians. Its aliases include Dongdang, Taidang, Ludang, and Kouang.

[0015] The Salvia miltiorrhiza is the dried root and rhizome of Salvia miltiorrhiza in the genus Salvia of the family Lamiaceae. It has a bitter taste and a slightly cold nature, and belongs to the heart and liver meridians. Its aliases include Honggen, Dahongpao, and Xueshengen.

[0016] The Schisandra chinensis is the dried ripe fruit of Schisandra chinensis in the family Magnoliaceae. It is warm in nature, sour and sweet, and belongs to the lung, heart, and kidney meridians. Its aliases include Xuanji, Huiji, Wumeizi, Shanhuajiao, Zhuangwei, and Schisandra chinensis.

[0017] The Ophiopogon japonicus is the tuberous root of the perennial herbaceous plant Ophiopogon japonicus in the genus Ophiopogon of the family Asparagaceae. It has a sweet and slightly bitter taste, and a slightly cold nature, and belongs to the heart, lung, and stomach meridians. Its aliases include Ophiopogon japonicus, Ophiopogon bodinieri, Hang Ophiopogon japonicus, Chuan Ophiopogon japonicus, Cundong, Xiaomaimendong, and Jiuye Ophiopogon japonicus.

[0018] The red ginseng is the dried root of the cultivated product of Panax ginseng in the family Araliaceae (commonly known as "round ginseng") after steaming. It has a sweet and slightly bitter taste, and a warm nature, and belongs to the spleen, lung, heart, and kidney meridians. Its alias is red ginseng.

[0019] The polygonatum is the dried rhizome of Polygonatum kingianum Coll. et Hemsl., Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua of the Liliaceae family. It is of neutral nature and sweet taste, and belongs to the lung meridian, spleen meridian and kidney meridian. Its aliases include dragon bite, bletilla striata, rabbit bamboo, hanging pearl, chicken lattice, rice preserved fruit, dodder bamboo, deer bamboo, paris polyphylla, poverty relief, wěiruí, gouge, horse arrow, etc.

[0020] The astragalus membranaceus is the root of Astragalus membranaceus (Fisch.) Bunge of the Leguminosae family. It has a sweet taste and a slightly warm nature, and belongs to the spleen and lung meridians. Its aliases include astragalus membranaceus var. mongholicus (Bunge) Hsiao & K. C. Hsia, cotton astragalus membranaceus, membranous milkvetch root, etc.

[0021] The wild jujube seed is the dried ripe seed of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow of the Rhamnaceae family. It has a sweet and sour taste and a neutral nature, and belongs to the heart, spleen, liver and gallbladder meridians. Its aliases include jujube seed, wild jujube kernel, etc.

[0022] The prepared licorice root is the processed product of licorice root (the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the Leguminosae family) after being stir-fried with honey. It has a sweet taste and a slightly warm nature, and belongs to the heart, lung, spleen and stomach meridians. The aliases of licorice include sweet root, red licorice, powdered licorice, licorice root, cortex glycyrrhizae, stick licorice, etc.

[0023] Due to the adoption of the above technical solution, the beneficial effects obtained by the present invention are as follows: The prescription mechanism of the present invention takes the simultaneous tonifying of qi and blood and the regulation of yin and yang as the core. Through the synergistic effect of multiple traditional Chinese medicines, aiming at the pathological basis of qi and blood deficiency and qi and yang deficiency, it takes into account the heart and spleen, soothes the nerves and improves intelligence, and nourishes yin and promotes fluid production. The specific mechanism analysis is as follows: (1) Simultaneously tonify qi and blood and regulate yin and yang Codonopsis pilosula and astragalus membranaceus: Codonopsis pilosula replenishes middle qi and invigorates the spleen and lungs, and astragalus membranaceus supplements qi and raises yang, and consolidates the exterior and stops sweating. The two are used as the monarch drugs to strengthen the qi-tonifying power and promote the source of qi and blood generation, aiming at symptoms such as fatigue, lassitude, shortness of breath and weakness caused by qi deficiency; Ginseng rubra and polygonatum: Ginseng rubra greatly supplements primordial qi and restores pulse and arrests collapse, and polygonatum supplements qi and nourishes yin, strengthens the spleen and moistens the lungs. The two are used as the ministerial drugs together. They not only assist the monarch drug in supplementing qi, but also take into account the deficiency of yin and blood, realizing the simultaneous tonifying of qi and blood and the regulation of yin and yang, and improving manifestations of qi and blood deficiency such as palpitations, shortness of breath and sallow complexion; (2) Nourish yin and promote fluid production, moisten dryness and soothe the heart Ophiopogon japonicus and schisandra chinensis: Ophiopogon japonicus nourishes yin and promotes fluid production, moistens the lungs and clears the heart, and schisandra chinensis astringes and arrests sweating, supplements qi and promotes fluid production. The two are used as the assistant drugs, aiming at symptoms such as dry mouth, tongue and vexed insomnia caused by qi and yin deficiency. By nourishing yin and moistening dryness, soothing the nerves and calming the mind, they balance yin and yang in the body and relieve internal disturbance of deficiency heat; Wild jujube seed: Wild jujube seed nourishes the heart and soothes the liver, soothes the nerves and arrests sweating, further enhancing the effect of nourishing yin and soothing the nerves, and improving symptoms such as neurasthenia and dreamful insomnia; (3) Warmly invigorate the heart and spleen, soothe the nerves and improve intelligence Salvia miltiorrhiza and roasted licorice root: Salvia miltiorrhiza promotes blood circulation to remove blood stasis and clears the heart to relieve restlessness, while roasted licorice root invigorates the spleen and stomach, replenishes qi and restores the pulse. The two are adjuvant drugs. Salvia miltiorrhiza improves blood stasis in the heart vessels through activating blood circulation and dredging collaterals, and roasted licorice root harmonizes all the drugs and alleviates acute pain. The two work together to promote the recovery of the heart and spleen functions and relieve symptoms such as palpitations, chest distress and shortness of breath. Red ginseng and codonopsis pilosula: Red ginseng warms and tonifies the qi of the heart and spleen, and codonopsis pilosula invigorates the spleen and benefits the lungs. The two together enhance the functions of the heart and spleen and improve manifestations such as memory loss and inattention caused by deficiency of both the heart and spleen. (4) Synergistic effect and treatment of both the principal and secondary aspects of a disease Overall compatibility: The drugs in the formula act synergistically through multiple pathways such as supplementing qi to generate blood, nourishing yin to promote fluid production, warming and tonifying the heart and spleen, calming the mind and improving intelligence. It not only targets the pathological basis of qi and blood deficiency and deficiency of both qi and yang, but also takes into account the secondary symptoms such as disharmony of heart and spleen functions and restlessness of mind, achieving treatment of both the principal and secondary aspects of a disease. Balanced drug properties: Red ginseng and astragalus membranaceus are warming and tonifying without being dry, ophiopogon japonicus and schisandra chinensis are nourishing yin without being greasy, and salvia miltiorrhiza promotes blood circulation without damaging healthy qi. The overall drug properties are mild and suitable for long-term conditioning. Specific implementation mode

[0024] The present invention will be further described in detail below with reference to specific embodiments: Example 1 - A traditional Chinese medicine composition for treating qi and blood deficiency type fatigue and its preparation method The weight parts of each raw material used for preparing the traditional Chinese medicine composition are as follows: 2 parts of codonopsis pilosula, 3 parts of salvia miltiorrhiza, 1 part of schisandra chinensis, 2 parts of ophiopogon japonicus, 1 part of red ginseng, 1 part of polygonatum sibiricum, 3 parts of astragalus membranaceus, 2 parts of wild jujube seed, 1 part of roasted licorice root; Its preparation method includes the following steps: Step 1: Crush red ginseng and polygonatum sibiricum in the above raw material herbs and pass through a 10-mesh sieve to make coarse powder of the herbs; Step 2: Moisten the prepared coarse powder of the herbs with 55% - 75% ethanol for 2 hours until completely soaked; Step 3: Place the moistened coarse powder of the herbs in a percolator and gently compact it; Step 4: Add 55% - 75% ethanol to completely submerge the coarse powder of the herbs in the percolator and continue to soak for 24 hours; Step 5: After the soaking is completed, use 55% - 75% ethanol as the solvent and percolate at a rate of 3 ml•min -1 •kg -1 while keeping the inlet and outlet liquid rates consistent; Step 6: Let the percolated medicinal liquid stand and then filter it, collect the filtrate and reserve it; Step 7: Mix the remaining raw material herbs codonopsis pilosula, salvia miltiorrhiza, schisandra chinensis, ophiopogon japonicus, astragalus membranaceus, wild jujube seed, roasted licorice root with the medicinal powder residue remaining after percolation in Step 6, add 8 - 10 times water and soak for 30 min - 60 min; Step 8: Heat and decoct the medicinal materials soaked in Step 7 twice, each time for 1 to 2 hours, and collect and combine the decoction obtained from the decoction; Step 9: Concentrate the decoction obtained in Step 8 to a relative density of 1.12 - 1.16 (80 °C) to obtain a concentrated solution, and then cool it to room temperature; Step 10: Add 55% - 75% ethanol to the concentrated solution obtained by concentrating in Step 9, and keep stirring during this process to make the alcohol content in the decoction reach 65%. Then let it stand for 12 to 24 hours, filter, and collect the filtrate; Step 11: Mix the filtrate obtained by filtering in Step 6 with the filtrate obtained by filtering in Step 10, and then heat to completely volatilize the ethanol in the decoction, thereby removing the ethanol; Step 12: Add sucrose to the filtrate after removing ethanol in Step 11, then fill it into containers, and sterilize it by high-temperature steam sterilization method (that is, under the conditions of the decoction reaching 105 °C for 40 minutes).

[0025] Example 2 - A traditional Chinese medicine composition for treating fatigue of qi and blood deficiency type and its preparation method The weight parts of each raw material used for preparing this traditional Chinese medicine composition are as follows: Codonopsis pilosula 6 parts, Salvia miltiorrhiza 7 parts, Schisandra chinensis 4 parts, Ophiopogon japonicus 6 parts, Red Ginseng 3 parts, Polygonatum sibiricum 3 parts, Astragalus membranaceus 3 parts, Ziziphus jujuba var. spinosa 4 parts, Honey-fried Licorice Root 3 parts.

[0026] This example adopts the same preparation method as Example 1, the difference lies in the weight part ratio of each raw material.

[0027] Example 3 - A traditional Chinese medicine composition for treating fatigue of qi and blood deficiency type and its preparation method The weight parts of each raw material used for preparing this traditional Chinese medicine composition are as follows: Codonopsis pilosula 4 parts, Salvia miltiorrhiza 5 parts, Schisandra chinensis 2 parts, Ophiopogon japonicus 4 parts, Red Ginseng 2 parts, Polygonatum sibiricum 2 parts, Astragalus membranaceus 4 parts, Ziziphus jujuba var. spinosa 2 parts, Honey-fried Licorice Root 2 parts.

[0028] Similarly, this example also adopts the same preparation method as Example 1, the difference lies in the weight part ratio of each raw material.

[0029] Effect test part: This invention's research selected outpatients and inpatients from Liuzhou Traditional Chinese Medicine Hospital from January 2024 to December 2024. Inclusion criteria: Meeting the diagnostic criteria of qi and blood deficiency, and qi and yang deficiency. The main symptoms include fatigue, palpitations, shortness of breath, fear of cold, cold limbs, insomnia, and dreaminess. Exclusion criteria: Those with severe organic diseases, damp-heat syndrome, or yin deficiency with excessive fire. Among them, there were 35 males and 45 females, aged 40 - 75 years old, with an average age of (47 ± 5.7). According to the treatment plan, it was divided into a control group (40 cases) and an observation group (40 cases). The control group took Guipi Decoction orally according to the patient's condition (Astragalus membranaceus 15g, Atractylodes macrocephala 10g, Poria cocos 10g, Longan aril 10g, Ziziphus jujuba var. spinosa 10g, Aucklandia lappa 6g, Honey-fried Licorice Root 6g), 1 dose per day, decocted in water and taken in 2 times; the observation group took the prescription of this invention orally (that is, Codonopsis pilosula 2 - 6 parts, Salvia miltiorrhiza 3 - 7 parts, Schisandra chinensis 1 - 4 parts, Ophiopogon japonicus 2 - 6 parts, Red Ginseng 1 - 3 parts, Polygonatum sibiricum 1 - 3 parts, Astragalus membranaceus 3 - 6 parts, Ziziphus jujuba var. spinosa 2 - 4 parts, Honey-fried Licorice Root 1 - 3 parts, and adjusted the dosage ratio of the drugs based on the conditions of different patients on the basis of the above prescription). Usage method: 1 dose per day, decocted in water and taken in 2 times. Course of treatment: 4 weeks, observing the symptom changes before and after treatment. The observation results are shown in Table 1 below.

[0030] Efficacy evaluation criteria: Drawn up with reference to the Diagnostic and Therapeutic Criteria for Traditional Chinese Medical Diseases and Syndromes: Cured: Symptoms such as fatigue and palpitations completely disappear, physical strength is restored, and can work and live normally; Markedly effective: Symptoms are significantly improved, and the fatigue feeling is reduced by more than 70%; Effective: Symptoms are partially relieved, and the fatigue feeling is reduced by 30% - 70%; Ineffective: Symptoms show no improvement or get worse.

[0031] Table 1 .

[0032] Conclusion: It can be seen from the above research that the total effective rate of the observation group (the prescription of this invention) is significantly higher than that of the control group (95% vs. 70%), especially in improving fatigue, palpitations, and listlessness. This prescription has a significant effect on fatigue of qi and blood deficiency type by tonifying qi and blood, warming and nourishing the heart and spleen, and regulating yin and yang, and has good safety.

[0033] Among them, this invention makes the following specific introduction for several cases among the above numerous cases: 1. Patient Wei XX, female, 49 years old Chief complaint: Due to work pressure in the past 3 months, physical strength is insufficient, palpitations and shortness of breath occur even with a little exertion, and it worsened after staying up late 1 week ago, accompanied by fatigue, weakness, cold limbs, poor appetite, and loose stools.

[0034] Current medical history: The patient gradually felt a decline in physical strength due to work pressure 3 months ago. He felt palpitations and shortness of breath after a little activity, which could be relieved after rest. He did not receive systematic treatment. One week ago, the symptoms worsened after staying up late to work overtime. He had frequent palpitations, shortness of breath when moving, accompanied by fatigue, cold limbs, frequent dreams at night, easy awakening, dizziness in the morning, poor appetite and loose stools. Self-administered "Guipi Pills" had no obvious effect. Physical examination: pale complexion, pale lips and nails, pale and fat tongue with teeth marks on the edges, thin white fur, and deep and weak pulse.

[0035] Western medicine diagnosis: Neurasthenia; functional palpitations to be investigated (anemia, abnormal thyroid function, etc. need to be ruled out).

[0036] TCM diagnosis: palpitations (deficiency of both Qi and blood and deficiency of Qi and Yang).

[0037] Treatment principle: Nourish Qi and blood, warm Yang and strengthen spleen, nourish the heart and calm the mind.

[0038] Treatment method: Orally take the oral liquid preparation prepared by the prescription of the present invention, 10 ml each time, 3 times a day, orally. The prescription is composed of 2 parts of Codonopsis pilosula, 3 parts of Salvia miltiorrhiza, 2 parts of Schisandra chinensis, 2 parts of Ophiopogon japonicus, 3 parts of Red Ginseng, 3 parts of Polygonatum sibiricum, 6 parts of Astragalus, 2 parts of Ziziphus jujuba seeds, and 1 part of Radix Glycyrrhizae Preparata.

[0039] Lifestyle adjustment: avoid staying up late and overwork, do moderate exercise (such as Ba Duan Jin), and eat warm and nourishing food (such as yam and red date porridge).

[0040] Efficacy: After 1 week, the patient's palpitations and shortness of breath were relieved, the limbs became warm, the appetite improved, and the stool gradually formed. The pulse was stronger than before, the tongue was pale and the tooth marks were reduced. After 2 weeks, the symptoms were significantly relieved, the physical strength was restored, and the patient slept well at night. It is recommended to continue taking the oral liquid preparation made from the prescription of the present invention for 1 month to consolidate the efficacy, and there was no recurrence during follow-up.

[0041] 2. Patient Chen, female, 60 years old Chief complaint: In the past six months, the patient has gradually developed palpitations and shortness of breath due to overwork, which worsens with movement, accompanied by dizziness, fatigue, chills and cold limbs, restless sleep, frequent dreams and easy awakening; in the past month, the patient has lost appetite and has loose stools (especially in the morning).

[0042] Current medical history: Half a year ago, the patient gradually felt palpitations and shortness of breath after work, which worsened after activities and slowed down after rest. She also had dizziness, fatigue, chills, cold limbs, restless sleep, and frequent dreams. In the past month, she had anorexia and loose stools (obvious in the morning). After taking "Ejiao Blood-Supplementing Granules", the symptoms were slightly relieved but easily recurred. She was usually weak and had a "hysteromyomectomy" three years ago. The anemia after the operation was not completely corrected. She denied other chronic diseases.

[0043] Physical examination: pale complexion, pale lips and nails, pale tongue with teeth marks on the edges, thin white fur; pulse is deep, thready and weak, especially on the radial side.

[0044] Western medicine diagnosis: chronic anemia, functional dyspepsia (related to weak spleen and stomach).

[0045] TCM diagnosis: palpitations (deficiency of both Qi and blood, and deficiency of both Qi and Yang).

[0046] Pathogenesis: Long-term illness causes physical weakness, Qi and blood have not recovered after surgery, fatigue damages the spleen, spleen deficiency leads to insufficient biochemical metabolism, Qi and blood deficiency, and the heart is not nourished; over time, it affects the kidneys, spleen and kidney yang deficiency, and the warming function is impaired.

[0047] Treatment principle: Nourish Qi and blood, warm and nourish the heart and spleen, nourish the heart and calm the mind.

[0048] Treatment method: Orally take the oral liquid preparation prepared by the prescription of the present invention, 10 ml each time, 3 times a day, orally. The prescription consists of 3 parts of Codonopsis pilosula, 5 parts of Salvia miltiorrhiza, 1 part of Schisandra chinensis, 2 parts of Ophiopogon japonicus, 2 parts of Red Ginseng, 1 part of Polygonatum sibiricum, 6 parts of Astragalus, 2 parts of Ziziphus jujuba seeds, and 1 part of Radix Glycyrrhizae Preparata.

[0049] Lifestyle care: The diet should be warm and nourishing, such as red dates and yam porridge, angelica, ginger and mutton soup; avoid raw, cold and greasy food. Avoid fatigue, moderate exercise; pay attention to keeping warm, especially the waist, abdomen and lower limbs.

[0050] Efficacy: After 1 week, palpitations and shortness of breath were relieved, fear of cold was relieved, stool gradually formed, and appetite improved. Tongue and pulse were the same as before. After 2 weeks, dizziness and fatigue were significantly improved, sleep became peaceful, and pulse was stronger than before. Continue to take the oral liquid preparation made by the prescription of the present invention for 1 month, and regularly check blood routine.

[0051] 3. Patient Zhao, female, 35 years old Chief complaint: fatigue and palpitations 2 years after delivery, numbness of limbs, scanty and light-colored menstruation in the past 3 months, accompanied by shortness of breath, laziness to speak, night sweats and chills.

[0052] Current medical history: The patient had improper postpartum adjustment 2 years ago, and gradually developed fatigue, palpitations (aggravated by cold). In the past 3 months, she has numbness in her limbs, pale complexion, scanty and pale menstruation, prolonged menstruation, shortness of breath, laziness, night sweats, slight heat in the palms and soles but fear of cold. She had a history of postpartum hemorrhage and long-term irregular menstruation; a history of "chronic superficial gastritis" for 5 years, with occasional dull pain in the stomach. The tongue is pale and tender, with a slightly red tip and little coating; the pulse is weak and slightly rapid, and the left Guan pulse is stringy and thin.

[0053] Western medicine diagnosis: postpartum anemia, autonomic nervous system dysfunction, chronic superficial gastritis, and menstrual disorders.

[0054] TCM diagnosis: asthenia (deficiency of both Qi and blood, damage to both Qi and Yin, and liver-blood deficiency).

[0055] Pathogenesis: Postpartum blood loss damages Qi, Qi and blood have not recovered, long-term deficiency affects Yin, and both Qi and Yin are damaged; liver blood is insufficient, tendons and veins are not nourished; Yin cannot restrain Yang, and internal heat is generated.

[0056] Treatment principle: tonify Qi and nourish blood, nourish Yin and produce body fluid, and harmonize the liver and spleen.

[0057] Treatment method: Orally take the oral liquid preparation made from the medicinal formula of the present invention, 10 ml each time, 3 times a day. Composition of the medicinal formula by weight parts: 4 parts of Codonopsis pilosula, 5 parts of Salvia miltiorrhiza, 4 parts of Schisandra chinensis, 2 parts of Ophiopogon japonicus, 3 parts of Red Ginseng, 2 parts of Polygonatum sibiricum, 3 parts of Astragalus membranaceus, 3 parts of Ziziphus jujuba var. spinosa, 1 part of Honey-fried Licorice Root.

[0058] Life care: Eat more nourishing foods such as red dates, wolfberries, and Chinese yams, avoid fatigue, keep warm, and keep a happy mood.

[0059] Therapeutic effect: After 1 week, the fatigue is reduced, the palpitations are less frequent, and the night sweats are improved. After 2 weeks, the numbness in the limbs is reduced, the appetite is improved, and the menstrual volume increases compared with before. After 4 weeks: All symptoms are significantly improved, the complexion turns rosy, and the pulse is stronger than before.

[0060] 4. Patient Zhang, male, 25 years old Chief complaint: Palpitations for 1 year after long-term staying up late, accompanied by mental trance and inattentiveness, and eyelid edema in the morning for the past 2 weeks.

[0061] Current medical history: The patient has gradually developed palpitations, mental trance, inattentiveness, accompanied by tinnitus like cicadas in the past 1 year due to long-term staying up late for exam preparation. The physical strength has decreased significantly, sweating profusely even with a little exertion, the limbs are cold, and the waist and knees are weak. Eyelid edema in the morning for the past 2 weeks, and the urine is clear and long. Usually sitting for a long time and moving little; having a history of "hypothyroidism" for 1 year and taking "Euthyrox" for a long time, with good control. The tongue is pale, plump and enlarged, with obvious tooth marks on the edges, and the tongue coating is white and slippery; the pulse is deep, slow and weak, and the pulses at both chi positions are weak.

[0062] Western medicine diagnosis: 1. Hypothyroidism (controlled by drugs); 2. Autonomic nerve dysfunction; 3. Neurasthenia.

[0063] Traditional Chinese medicine diagnosis: Palpitations (syndrome of deficiency of both the heart and spleen, and deficiency of spleen and kidney yang).

[0064] Pathogenesis: Overwork injures the spleen, resulting in insufficient production of qi and blood; prolonged illness affects the kidney, leading to deficiency of kidney yang and failure to transform water and dampness; the heart loses nourishment and the spirit fails to be contained.

[0065] Treatment principle: Warm and tonify the spleen and kidney, replenish qi and blood, and calm the heart and soothe the nerves.

[0066] Treatment method: Orally take the oral liquid preparation made from the medicinal formula of the present invention, 10 ml each time, 3 times a day. Composition of the medicinal formula by weight parts: 6 parts of Codonopsis pilosula, 4 parts of Salvia miltiorrhiza, 3 parts of Schisandra chinensis, 5 parts of Ophiopogon japonicus, 1 part of Red Ginseng, 2 parts of Polygonatum sibiricum, 3 parts of Astragalus membranaceus, 3 parts of Ziziphus jujuba var. spinosa, 1 part of Honey-fried Licorice Root.

[0067] Life care: Ensure sufficient sleep, avoid staying up late, exercise moderately, and eat more warm and tonifying foods such as Chinese yams, walnuts, and mutton.

[0068] Therapeutic effect: After 1 week, palpitations were alleviated, the spirit became more concentrated than before, eyelid edema subsided. After 2 weeks: physical strength improved, sweating decreased, and the limbs became warmer. After 4 weeks: all symptoms improved significantly, the tongue manifestation improved, and the pulse became stronger than before.

[0069] 5. Patient Wu, male, 40 years old Chief complaint: Repeated insomnia and dreaminess for 5 years, aggravated with palpitations and chest tightness for half a year.

[0070] Present medical history: The patient was diagnosed with "neurasthenia" 5 years ago and has had long-term insomnia and dreaminess. The symptoms have worsened in the past half year, with frequent palpitations and accompanied by chest tightness and shortness of breath (especially severe at night, requiring sitting up to relieve). Currently, the patient is fatigued, has a poor appetite, abdominal distension after eating, and loose stools (2 - 3 times a day). Due to long-term high work pressure and an anxious temperament; has a history of "chronic colitis" for 10 years and often has diarrhea due to improper diet. The tongue is pale purple, the tongue body is enlarged, and the tongue coating is white and greasy; the pulse is soggy and slow, and the right guan pulse is deep and weak.

[0071] Western medicine diagnosis: 1. Neurasthenia; 2. Anxiety state; 3. Chronic colitis; 4. Functional dyspepsia.

[0072] Traditional Chinese medicine diagnosis: Insomnia (syndrome of deficiency of both the heart and spleen, and obstruction of damp - turbidity in the middle - jiao).

[0073] Pathogenesis: Worry injures the spleen, the spleen fails to transport and transform, damp - turbidity is generated internally; qi and blood production is insufficient, the heart loses nourishment; damp - turbidity disturbs the mind.

[0074] Treatment principle: Strengthen the spleen and resolve dampness, nourish the heart and calm the mind, regulate qi and blood.

[0075] Treatment method: Oral administration of the oral liquid preparation made from the prescription of the present invention, 10 ml each time, 3 times a day. The weight parts composition of the prescription: 5 parts of Codonopsis pilosula, 5 parts of Salvia miltiorrhiza, 4 parts of Schisandra chinensis, 4 parts of Ophiopogon japonicus, 2 parts of Red Ginseng, 3 parts of Polygonatum sibiricum, 3 parts of Astragalus membranaceus, 2 parts of Ziziphus jujuba var. spinosa, 1 part of Honey - fried Licorice Root.

[0076] Life care: Light and easy - to - digest diet, avoid raw, cold, and greasy foods, keep a happy mood, appropriately relieve stress, have regular daily routines, and soak feet in hot water before going to bed.

[0077] Therapeutic effect: After 1 week, insomnia improved, palpitations were alleviated, and abdominal distension was relieved. After 2 weeks: appetite increased, stools became formed, 1 - 2 times a day. After 4 weeks, all symptoms improved significantly, the tongue coating turned thin and white, and the pulse became stronger than before.

[0078] It should be noted that: The above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A traditional Chinese medicine composition for treating fatigue of qi and blood deficiency type, characterized in that Prepared from the following raw materials: Codonopsis pilosula, Salvia miltiorrhiza, Schisandra chinensis, Ophiopogon japonicus, Red Ginseng, Polygonatum sibiricum, Astragalus membranaceus, Ziziphus jujuba var. spinosa, Honey-fried Licorice Root.

2. The traditional Chinese medicine composition for treating fatigue of qi and blood deficiency type according to claim 1, wherein The weight parts of each raw material are as follows: Codonopsis pilosula 2 parts - 6 parts, Salvia miltiorrhiza 3 parts - 7 parts, Schisandra chinensis 1 part - 4 parts, Ophiopogon japonicus 2 parts - 6 parts, Red Ginseng 1 part - 3 parts, Polygonatum sibiricum 1 part - 3 parts, Astragalus membranaceus 3 parts - 6 parts, Ziziphus jujuba var. spinosa 2 parts - 4 parts, Honey-fried Licorice Root 1 part - 3 parts.

3. The traditional Chinese medicine composition for treating fatigue of qi and blood deficiency according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition for treating fatigue of qi and blood deficiency is made into an oral liquid preparation for oral administration.

4. A preparation method of a traditional Chinese medicine composition for treating fatigue of qi and blood deficiency, characterized in that: The following medicinal materials are used as raw materials: Codonopsis pilosula, Salvia miltiorrhiza, Schisandra chinensis, Ophiopogon japonicus, Red Ginseng, Polygonatum sibiricum, Astragalus membranaceus, Ziziphus jujuba var. spinosa, Honey-fried Licorice Root; Its preparation method comprises the following steps: Step 1: Make Red Ginseng and Polygonatum sibiricum in the above raw medicinal materials into medicinal powders; Step 2: Moisten the made medicinal powders with ethanol; Step 3: Place the moistened medicinal powders in a percolator; Step 4: Add ethanol to submerge the medicinal powders in the percolator and continue to soak; Step 5: After the soaking is completed, use ethanol as the solvent and carry out percolation at a rate of 3 ml•min-1•kg-1 of volume flow rate; Step 6: Let the percolated medicinal liquid stand and filter, collect the filtrate and set aside; Step 7: Mix the remaining raw medicinal materials Codonopsis pilosula, Salvia miltiorrhiza, Schisandra chinensis, Ophiopogon japonicus, Astragalus membranaceus, Ziziphus jujuba var. spinosa, Honey-fried Licorice Root with the medicinal powder residue remaining after percolation in Step 6, and soak with water; Step 8: Heat and decoct the medicinal materials soaked in Step 7 twice, and collect and combine the decocted medicinal liquids; Step 9: Concentrate the medicinal liquid obtained in Step 8 to obtain a concentrated liquid; Step 10: Add ethanol to the concentrated liquid obtained by concentrating in Step 9, stir, stand, filter, and collect the filtrate; Step 11: Mix the filtrate obtained by filtering in Step 6 with the filtrate obtained by filtering in Step 10, and then heat to remove ethanol.

5. The traditional Chinese medicine composition for treating qi and blood deficiency type fatigue according to claim 4, characterized in that The weight parts of each raw material are as follows: Codonopsis pilosula 2 parts - 6 parts, Salvia miltiorrhiza 3 parts - 7 parts, Schisandra chinensis 1 part - 4 parts, Ophiopogon japonicus 2 parts - 6 parts, Red Ginseng 1 part - 3 parts, Polygonatum sibiricum 1 part - 3 parts, Astragalus membranaceus 3 parts - 6 parts, Ziziphus jujuba var. spinosa 2 parts - 4 parts, Honey-fried Licorice Root 1 part - 3 parts.

6. The traditional Chinese medicine composition for treating qi and blood deficiency type fatigue according to claim 4 or 5, wherein It further comprises the following steps: Step 12: Add sucrose to the filtrate after removing ethanol in Step 11, and then fill and sterilize.