32 results about "Inhibitory neuron" patented technology

Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.

Apparatus and methods for contrast enhancement and feature identification. In one implementation, an image processing apparatus utilizes latency coding and a spiking neuron network to encode image brightness into spike latency. The spike latency is compared to a saliency window in order to detect early responding neurons. Salient features of the image are associated with the early responding neurons. An inhibitory neuron receives salient feature indication and provides inhibitory signal to the other neurons within an area of influence of the inhibitory neuron. The inhibition signal reduces probability of responses by the other neurons to stimulus that is proximate to the feature thereby increasing contrast within the encoded data. The contrast enhancement may facilitate feature identification within the image. Feature detection may be used for example for image compression, background removal and content distribution.

Apparatus and methods for activity based plasticity in a spiking neuron network adapted to process sensory input. In one embodiment, the plasticity mechanism may be configured for example based on activity of one or more neurons providing feed-forward stimulus and activity of one or more neurons providing inhibitory feedback. When an inhibitory neuron generates an output, inhibitory connections may be potentiated. When an inhibitory neuron receives inhibitory input, the inhibitory connection may be depressed. When the inhibitory input arrives subsequent to the neuron response, the inhibitory connection may be depressed. When input features are unevenly distributed in occurrence, the plasticity mechanism is capable of reducing response rate of neurons that develop receptive fields to more prevalent features. Such functionality may provide network output such that rarely occurring features are not drowned out by more widespread stimulus.

The invention provides a culture medium for the induced differentiation of functional cerebral cortical cells. The culture medium is prepared from a nerve cell culture medium and a nutrient additive,wherein the nutrient additive is selected from one or more of SU5402, BIBF1120, IBMX and glucose. The invention provides an induced differentiation method of the functional cerebral cortical cells. Specific factors such as an inhibitor of FGF and VEGF signal channels and an activator of cAMP are added in a specific time of the induced differentiation of various nerve cells from the nerve stem cells or nerve precursor cells to accelerate the differentiation and maturation of the nerve cells, the stable and healthy nerve cells having a main function can be obtained in about 7 to 14 days of the induced differentiation from the human nerve precursor cells, and the nerve cells comprise excitable nerve cells and inhibitory nerve cells, so that the in-vivo cultured human nerve cells can be actually applied to the field of the drug screening and the like, the production cost can be reduced, and the production period can be shortened.

The invention discloses a probabilistic neuron circuit, a topological structure of a probabilistic neural network and an application thereof. The probabilistic neuron circuit comprises an integral capacitor, a non-fixed threshold volatile device and a load resistor; One end of the fixed-threshold volatile device, and the other end of the volatile device is connected to one end of the load resistor. The network topology includes multiple input neuron circuits, multiple probabilistic neuron circuits, and lateral inhibitory neuron circuits; each probabilistic neuron circuit is used to perform a neural network based on its non-fixed excitation threshold and the electrical signals emitted by each input neuron circuit. Random excitation; the inhibitory neuron circuit is used to inhibit the excitation of other subsequent probabilistic neuron circuits when receiving the signals excited by the first n probability neuron circuits. The invention introduces a non-fixed threshold volatile device into the neuron circuit, which greatly expands the application of the neuron circuit, especially can be used to solve non-deterministic problems, and has reliable solution results.

The present invention proposes a side-inhibition neuron circuit based on a ferroelectric transistor FeFET, which includes a capacitor, a reset tube, a positive feedback tube, two-stage series inverters, and a ferroelectric transistor; wherein, the capacitor is used to simulate biological The cell membrane capacitance of the neuron accumulates the charge brought by the input post-synaptic current; the reset tube is an N-type MOSFET device that provides a reset path for the charge accumulated on the capacitor; the positive feedback tube is a P-type MOSFET device, When the input of the first-stage inverter is close to its logic threshold level, it replenishes the charge for the capacitor; the two-stage series inverter is composed of two sets of complementary CMOS, which amplifies the voltage change at the input terminal, and the pulse is generated at its output terminal. ; The ferroelectric transistor is an N-type FeFET device used to mimic the lateral inhibition function of biological neurons. The invention can significantly reduce the hardware overhead; meanwhile, it highly simulates the basic characteristics and advanced functions of biological neurons.

The invention belongs to the technical field of medicines, and particularly relates to novel application of dihydromyricetin. According to the invention, through dihydromyricetin, the ATP supply of the brain is increased, and the protein level of Gephyrin is increased; the Gephyrin is the core skeleton protein of a central nervous system (CNS) inhibitory post-synaptic protein network, has the effects of participating in the formation of inhibitory synapses, stabilizing inhibitory synaptic receptors, regulating synaptic plasticity and the like, and has the function of improving the inhibitory neurons of the brain; and the dihydromyricetin can improve dependence and withdrawal reaction of animals on morphine and alcohol by adjusting the functions of GABA (gamma-aminobutyric acid) and dopaminergic neurons, and is high in safety.