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Novel application of dihydromyricetin

A new technology of dihydromyricetin, applied in the field of medicine, can solve the problems of insufficient safety, methadone dependence and addiction, and achieve the effects of high safety, increased ATP supply, and increased protein levels

Pending Publication Date: 2022-02-18
国科特膳江苏生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the above-mentioned prior art, the present invention provides a new application of dihydromyricetin, the purpose of which is to solve the problem of drug dependence / addiction in the prior art by taking countermeasures such as methadone. Methadone itself is also a kind of drug, which is easy to Technical problems causing methadone addiction and insufficient safety

Method used

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  • Novel application of dihydromyricetin
  • Novel application of dihydromyricetin
  • Novel application of dihydromyricetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The dihydromyricetin in this example is dihydromyricetin extracted from Maoyanberry (vine tea). extraction methods such as figure 2 As shown, the specific steps are as follows:

[0027] S1, pulverize the vine tea, add 8 times the amount of water to filter and extract 3 times, and obtain the extract;

[0028] S2, the extract in step S1 is adsorbed through 101 resin adsorption columns. In this process, determine whether the adsorption column is saturated by spotting the plate, and then use 10% ethanol in turn (during the rinsing process of 10% ethanol, use the spotting plate to determine impurity) and 30% ethanol to wash the adsorption column (30% ethanol washes to determine the target component by spotting the plate) to obtain the eluate;

[0029] S3, concentrating and filtering the eluent in step S2 to obtain a crude liquid;

[0030] S4, drying the crude liquid in step S3 to obtain 50% dihydromyricetin;

[0031] S5, the crude liquid in step S3 is subjected to ethan...

Embodiment 2

[0035] In the present embodiment, select 20 male adult SD rats (body weight 200-250g) disposable intraperitoneal injection of ethanol (20% ethanol solution, 20ml / kg), establish alcohol dependence model, be divided into two groups again: alcohol (20ml / kg) % ethanol solution, 20ml / kg)+water group, ethanol (20% ethanol solution, 20ml / kg)+DHM group (2mg / kg, be dissolved in drinking water), observe the spontaneous alcohol intake ( Put 20% alcohol solution in the experimental field, and the animals can drink it by themselves). Such as Figure 5 As shown, the alcohol intake in the alcohol + water group increased from 3.9 / kg / day to 7.4 g / kg / day at the end of the second week; while there was no significant change in the alcohol + DHM group. The alcohol + water group was divided into two subgroups at the seventh week, and the DHM 2mg / kg group was given and the original plan was followed. The alcohol intake of the DHM group decreased significantly. Alcohol intake in the group had been ...

Embodiment 3

[0037] In this embodiment, 20 male adult SD rats (body weight 200-250g) were selected and divided into four groups: normal saline, alcohol (3g / kg), alcohol (3g / Kg)+DHM (1mg / Kg), and DHM alone (1mg / kg), one-time intraperitoneal injection to establish alcohol dependence model. Elevated plus maze was used to evaluate the anxiety status after alcohol withdrawal. The results showed that alcohol significantly increased the anxiety performance (the animal’s time in the open arm was reduced, and the time in the closed area was prolonged), and alcohol + DHM could significantly improve the anxiety performance caused by alcohol ( Image 6 A) LORR (loss of righting reflex) time was used to evaluate alcohol tolerance, and the results showed that alcohol significantly reduced LORR time, indicating that the tolerance to narcotic and analgesic drugs was enhanced, while the alcohol+DHM group prolonged LORR time, Alleviate tolerance ( Image 6 B); use PTZ to induce convulsions to evaluate the ...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to novel application of dihydromyricetin. According to the invention, through dihydromyricetin, the ATP supply of the brain is increased, and the protein level of Gephyrin is increased; the Gephyrin is the core skeleton protein of a central nervous system (CNS) inhibitory post-synaptic protein network, has the effects of participating in the formation of inhibitory synapses, stabilizing inhibitory synaptic receptors, regulating synaptic plasticity and the like, and has the function of improving the inhibitory neurons of the brain; and the dihydromyricetin can improve dependence and withdrawal reaction of animals on morphine and alcohol by adjusting the functions of GABA (gamma-aminobutyric acid) and dopaminergic neurons, and is high in safety.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of dihydromyricetin. Background technique [0002] Withdrawal reactions occur when drug dependence / addicts stop giving drugs, which will involve the dysfunction of excitatory neurons and inhibitory neurons. Gephyrin, a functional protein in the brain, also has a role in drug dependence and withdrawal reactions. important role. At present, the existing products similar to drug addiction in the market are mainly methadone. Methadone itself is also a kind of drug, which is easy to cause methadone dependence and addiction, and there is a relatively large hidden danger in the safety of drug use. [0003] The chemical name of Dihydromyricetin (DMY) is (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4- Ketone is a kind of flavonoids. In addition to the general characteristics of flavonoids, it also has the functions of relieving alcohol poison...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P25/36
CPCA61K31/352A61P25/36
Inventor 万冬梅朱雁军
Owner 国科特膳江苏生物科技有限公司
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