3 results about "Trade offs" patented technology

A major obstacle in the field of biotherapeutics is the need for platform technologies that enable high bioavailability and long-term therapeutic exposure of biotherapies in localized disease. Traditional approaches result in problematic trade-offs, such as toxicity and off-target side effects. The present disclosure provides compounds comprising follistatin domain 1 (FSD1) of follistatin (FST), which can bind to biological structures, such as the extracellular matrix, via heparan sulfate without the undesired neutralizing effects on the activity of activin A, myostatin, and GDF11, as full-length follistatin does. The present invention relates to fusion or conjugated proteins, compositions thereof, constructs or vectors encoding them, their medical uses, and methods for biotherapeutics.

Described herein are optical systems that reduce channel crosstalk in semiconductor optical amplifiers (SOAs) without sacrificing suppression of noise due to amplified spontaneous emission, thereby overcoming trade-offs existing in conventional amplifiers. These schemes involve injection of continuous wave (CW) light into the SOA. The CW assist light may be provided at a wavelength within the transparency region of an SOA. Injecting CW assist light in the transparency region results in a speed-up of the carrier lifetime and gain recovery. Application of CW assist light in the transparency region establishes a feedback mechanism by which the more carriers are depleted, the faster the carrier recovery. Furthermore, the injection of CW light results in pinning of the carrier density and constant gain. CW light injection can be used in SOAs that use bulk, quantum-well, and quantum dot gain material.

In distributed data management traditional databases often struggle to maintain consistency and handle conflicts. Traditional solutions prioritize specific combinations of properties, resulting in trade-offs that impact user experience and application functionality. Present disclosure provides systems and methods that route incoming transaction associated with application to corresponding database server (DBS) by integrating geographical proximity mean value, and sender internet protocol affinity value. The incoming transaction is processed to extract data manipulation language (DML) operation written by the application and replicated to each DBS other than a DBS on which the application is directly applying a data through the incoming transactions. A primary key is generated by allocating an unique identifier if the DML operation is inserted on identified DBS. The primary key of record is updated from the incoming transaction. A conflict associated with parent and child association of the DML operation is dynamically monitored based on integrity Foreign key Constraint.