The invention discloses a millimeter wave large-scale MIMO system multi-user transmission method based on space division multiple access and interference suppression. A base station is provided with a millimeter wave large-scale uniform panel antenna array; a plurality of single-antenna users receive service from the base station on the same time-frequency resource; according to information of wave beam clusters selected by the users, a universal user set is divided into an interference-free user subset and an interference user subset; the space division multiple access transmission method based on double-layer pre-coded codes is adopted to the interference-free user subset, and the transmission method based on interference suppression is adopted to the interference user subset. According to the method, the advantages of two traditional multi-user transmission methods based on space division multiple access and interference suppression respectively are combined, and the bottleneck that in an FDD transmission mode, downlink channel information of a large-scale MIMO system is difficult to obtain is broken through; meanwhile, the computation complexity problem is solved, it is guaranteed that all the users can receive the service from the base station simultaneously, and considerable system performance and speed performance are achieved at limited feedback quantity.