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Application of dihydromyricetin as active ingredient in sleep disorder

A technology for dihydromyricetin and sleep disorders, applied in the field of medicine, can solve the problems of poor memory and insufficient safety, and achieve the effects of improving function, good safety, and improving nighttime sleep disorders.

Pending Publication Date: 2022-05-31
国科特膳江苏生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides the application of dihydromyricetin as an active ingredient in sleep disorders, the purpose is to solve the problem of dementia with sleep disorders and insomnia with anxiety / depression, taking anti-schizophrenia drugs or anti-psychotics. Insomnia, anti-anxiety and depression drugs and other countermeasures cause users drowsiness, fatigue, incoordination of limb movement, poor memory, sexual dysfunction and other adverse reactions, which have technical problems of dependence and tolerance, and insufficient safety

Method used

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  • Application of dihydromyricetin as active ingredient in sleep disorder
  • Application of dihydromyricetin as active ingredient in sleep disorder
  • Application of dihydromyricetin as active ingredient in sleep disorder

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The dihydromyricetin in this example is dihydromyricetin extracted from Maoyanberry (vine tea). extraction methods such as figure 2 As shown, 50% dihydromyricetin was obtained by filtering and drying, and 98% dihydromyricetin was obtained by recrystallization. Animal experiments were carried out using the DHM extracted by the above method.

[0030] Sixteen 20-month-old transgenic AD model mice (TG-SwDI) and 8 same-month-old non-transgenic mice (wild-type Wt) were selected as controls and divided into 3 groups: control group, AD model group, and AD treatment group (DHM 2mg / kg / day), orally (mixed in feed), used continuously for 3 months. At 1.5 months and 3 months, the brain Gephyrin protein levels of each group were detected, and the effect of DHM on the cognitive ability of AD model animals was observed. The new objective object recognition rate (ORI) and new content recognition rate (RI) were used as evaluation indicators. like image 3 showed that dihydromyriceti...

Embodiment 2

[0032] Select 30 volunteers suffering from sleep disorders (including early awakening, difficulty in falling asleep, fragmented sleep, etc.), aged 30-70 years, both men and women, using the dihydromyricetin that will be made as one of the active ingredients provided by this embodiment Medicine, the medicine provided in this embodiment is a solid beverage preparation (solid powder), and the method of use is to drink it with warm water. Take DHM 100mg each time, 1-2 times a day, continue to use for 4 weeks, observe the sleep time. The sleep time before taking the present embodiment is counted, and the sleep time after taking is also counted. like Figure 5 As shown, after taking the medicine provided in this embodiment, the sleep time of the volunteers was greatly prolonged, and the sleep quality was effectively optimized.

Embodiment 3

[0034] In this example, plants containing dihydromyricetin are used to prepare a food composition for treating dementia with sleep disorders.

[0035] The food composition comprises the following components by mass percentage: 10% of Maoyanberry, 10% of Hovenia dulcis, 30% of phosphatidylserine, 10% of stachyose, 10% of jujube seed, 5% of tartary buckwheat seedlings, and 5% of longan %, bayberry 5%, resistant dextrin 15%. The medicinal and edible food composition provided in this example is used as a treatment to prepare food for treating dementia with sleep disorders. The dosage form of the food composition with the same source of medicine and food provided in this example is a solid beverage preparation (solid powder), and the method of use is warm water ingestion.

[0036] Choose 10 patients with dementia with nocturnal restlessness (including senile dementia and vascular dementia), aged 60-80 years, both men and women, use the food composition with the same origin of medi...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of dihydromyricetin as an active ingredient in sleep disorder. According to the medicine prepared by taking dihydromyricetin as a raw material, the ATP supply of the brain can be increased, the Gephyrin protein level can be increased, and the function of brain inhibitory neurons (GAMA aminobutyric acid) can be improved; the compound can effectively improve the night sleep disorder of a dementia patient, especially the night dysphoria and excitement accompanied by the night sleep disorder, can regulate the function of dopaminergic neurons, plays a role in calming by regulating the function of inhibitory neurons, relieves the phenomena of anxiety, depression and insomnia, and is good in safety and free of dependence, tolerance and other adverse reactions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of dihydromyricetin as an active ingredient in sleep disorders. Background technique [0002] 70% of various dementias such as senile dementia, post-stroke dementia, and Parkinson's dementia are accompanied by sleep disorders. The common manifestations of sleep disorders are restlessness at night, excessive excitement, and sunset agitation. In the brains of dementia patients, there is an imbalance between inhibitory and excitatory neurons, and the sleep-wake rhythm is disrupted. Insomnia is also a sleep disorder, and insomnia accompanied by anxiety / depression is a common psychosomatic disease in modern life. Sleep-wake rhythm disorder in patients with insomnia, brain inhibitory neurons (GAMA neurons) dysfunction. The anxiety / depression accompanied by insomnia patients is mostly related to the imbalance of dopamine secretion in the brain. Currently ...

Claims

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Application Information

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IPC IPC(8): A23L33/10A23L33/105A23L2/39A23L2/40A61K36/87A61K36/899A61P25/20A61P25/22A61P25/24A61K31/198A61K31/664
CPCA23L33/10A23L33/105A23L2/39A23L2/40A61K36/87A61K31/664A61K36/72A61K31/198A61K36/725A61K36/88A61K36/899A61K36/28A61P25/22A61P25/20A61P25/24A23V2002/00A23V2200/322A23V2250/632A61K2300/00
Inventor 万冬梅朱雁军
Owner 国科特膳江苏生物科技有限公司
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