6results about How to "No reactivity" patented technology

The present application relates to the technical field of biology, and particularly discloses a polypeptide, a recombinant humanized collagen of type XIX and application thereof. The amino acid sequence of the polypeptide comprises n repeating units; the amino acid sequence of the repeating unit is shown in SEQ ID NO. 2. The polypeptide has a collagen triple helix structure, has good cell adhesion activity, can perform the function of human collagen, has no immune rejection and allergic reaction, and can be used in various fields such as cartilage repair, biological dressing, tissue filling and the like.

The invention provides recombinant humanized XVIII type collagen as well as a production method and application thereof, and belongs to the technical field of biosynthesis. The recombinant XVIII type humanized collagen has excellent cell adhesion activity and good biocompatibility, can be used for tissue repair, and does not generate immunological rejection and anaphylactic reaction when being applied to a human body.

This invention provides a feed enhancer specifically for low-salinity aquaculture of redclaw crayfish and its application. It belongs to the field of feed additive technology. This feed enhancer for low-salinity aquaculture of redclaw crayfish combines plant polysaccharides and probiotics in a synergistic manner, effectively leveraging the efficacy of both polysaccharides and probiotics. The synergistic effect significantly improves the redclaw crayfish's tolerance to low-salinity environments. Compared to traditional freshwater feed aquaculture of redclaw crayfish, it solves the problems of slow growth and high mortality rates, while also increasing yield, reducing the feed conversion ratio, and maximizing aquaculture efficiency. This provides technical support for the development of redclaw crayfish aquaculture in low-salinity areas of Guangxi and also enriches the varieties of marine aquaculture.

The invention relates to the technical field of biology, and particularly discloses a polypeptide, a recombinant X-type humanized collagen composed of the polypeptide and application of the recombinant X-type humanized collagen. A functional unit polypeptide of the present invention comprises a humanized alpha I chain protein or a variant thereof; wherein the sequence of the humanized alpha I chain protein is SEQ ID NO: 22, and the variant comprises one or more of the following mutations relative to the humanized alpha I chain protein: sequence truncation, site mutation / substitution and sequence addition. The recombinant polypeptide taking the functional unit polypeptide as a repetitive unit can promote cell proliferation activity and cell adhesion activity, and can be used for medical or non-medical application and filling, capacity increasing or repairing scenes of a plurality of tissues and organs of a human body.

The present application relates to the technical field of biotechnology, and particularly discloses a polypeptide, a recombinant humanized collagen of type XIX and application thereof. The amino acid sequence of the polypeptide comprises n repeating units; the repeating unit comprises any one of the following amino acid sequences or a variant sequence thereof: (1) an amino acid sequence shown in any one of SEQ ID NO. 1-2; (2) an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity with the amino acid sequence shown in any one of SEQ ID NO. 1-2; (3) a variant sequence obtained by mutating one or more amino acid residues in the amino acid sequence shown in any one of SEQ ID NO. 1-2; wherein n is an integer greater than or equal to 1. The polypeptide has a collagen triple helix structure, has good cell adhesion activity, can perform the function of human collagen, has no immune rejection and allergic reaction, and can be used in various fields such as cartilage repair, biological dressing and tissue filling.

This invention discloses a primer set, probe set, and kit for genetic risk detection of venous thromboembolism (VTE) in the Han Chinese population, belonging to the field of gene detection technology. The primer set is designed for seven key SNP sites associated with VTE in the Han Chinese population, covering anticoagulation, fibrinolysis, and metabolic systems. The probe set is paired with the primer set and uses multicolor fluorescent labeling. The kit contains the aforementioned primer set, probe set, and PCR buffer, and other core reagents, employing fluorescent multiplex PCR technology to accurately distinguish genotypes based on differences in melting curves. This invention closely matches the genetic characteristics of the Han Chinese population, offering excellent detection accuracy and specificity. It is simple and quick to operate, requires no complex equipment, and is cost-effective. It can rapidly assess genetic risk, facilitating early screening and prevention of VTE, and is suitable for large-scale application in medical institutions at all levels.