PH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel as well as preparation method and application of pH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel

A double-crosslinking, potion technology, used in the field of medical materials

Inactive Publication Date: 2021-05-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the above-mentioned problems in the prior art, the purpose of the present invention is to provide a pH-responsive double-crosslinked mussel biomimetic adhesion intelligent drug-loaded hydrogel and its preparation method and application, which can effectively solve the problems of existing hydro...

Method used

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  • PH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel as well as preparation method and application of pH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel
  • PH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel as well as preparation method and application of pH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel
  • PH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel as well as preparation method and application of pH-responsive bi-crosslinking mussel bionic adhesion intelligent drug-loaded hydrogel

Examples

Experimental program
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Embodiment 1

[0065] A method for preparing a pH-responsive double-crosslinked mussel biomimetic adhesion intelligent drug-loaded hydrogel, the reaction equation and preparation steps are as follows:

[0066]

[0067] (1) Synthesis of oxidized dextran polymer (OD)

[0068] Dextran (10.00 g) was accurately weighed and dissolved in 200 mL of deionized water, and 8.00 g of sodium periodate was added thereto. Then, stirred at 37° C. for 6 h, added 3 mL of ethylene glycol and stirred for 2 h to terminate the reaction. Finally, it was dialyzed in deionized water (pH7.4) for 3 days, and after 3 days, it was freeze-dried with a freeze dryer to obtain a purified polymer OD containing aldehyde groups;

[0069] (2) Synthesis of dopamine-modified oxidized dextran polymer (OD-DA)

[0070] OD (3.00g) and dopamine (DA, 3.00g) were completely dissolved in deionized water (50mL) at 37°C under nitrogen protection, and stirred continuously at 37°C for 12h; then the mixture was dialyzed in water for 3 day...

Embodiment 2

[0076] A method for preparing a pH-responsive double-crosslinked mussel biomimetic adhesion intelligent drug-loaded hydrogel, the preparation steps are as follows:

[0077] (1) Synthesis of oxidized methyl cellulose polymer

[0078] Accurately weighed methylcellulose (10.00 g) was dissolved in 200 mL of deionized water, and 8.00 g of sodium periodate was added thereto. Then, stirred at 37° C. for 6 h, added 3 mL of ethylene glycol and stirred for 2 h to terminate the reaction. Finally, it was dialyzed in deionized water (pH7.4) for 3 days, and after 3 days, it was freeze-dried with a freeze dryer to obtain a purified oxidized methyl cellulose polymer;

[0079] (2) Synthesis of dopamine-modified oxidized methyl cellulose polymer

[0080] Oxidized methylcellulose polymer (3.00g) and dopamine (DA, 3.00g) were completely dissolved in deionized water (50mL) at 37°C under nitrogen protection, and stirred continuously at 37°C for 12h; then The mixture was dialyzed in water for 3 d...

Embodiment 3

[0086] A method for preparing a pH-responsive double-crosslinked mussel biomimetic adhesion intelligent drug-loaded hydrogel, the preparation steps are as follows:

[0087] (1) Synthesis of oxidized hyaluronic acid polymer

[0088]Accurately weighed hyaluronic acid (10.00 g) was dissolved in 200 mL of deionized water, and 8.00 g of sodium periodate was added thereto. Then, stirred at 37° C. for 6 h, added 3 mL of ethylene glycol and stirred for 2 h to terminate the reaction. Finally, it was dialyzed in deionized water (pH=7.4) for 3 days, and after 3 days, it was freeze-dried with a freeze dryer to obtain a purified oxidized hyaluronic acid polymer;

[0089] (2) Synthesis of dopamine-modified oxidized hyaluronic acid polymer

[0090] Oxidized hyaluronic acid polymer (3.00g) and dopamine (DA, 3.00g) were completely dissolved in deionized water (50mL) at 37°C under nitrogen protection, and stirred continuously at 37°C for 12h; then the mixture was Dialyze in water for 3 days,...

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Abstract

The invention discloses pH-responsive bi-crosslinked mussel bionic adhesive intelligent drug-loading hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The preparation method of the pH-responsive adhesive intelligent drug-loading hydrogel comprises the following steps: oxidizing a polymer containing ortho-hydroxyl into a polymer containing an aldehyde group; carrying out a Schiff base reaction with molecules containing amino groups and catechol structures to prepare a functional polymer of which the side chain contains catechol structure micromolecules; a solution of the functional polymer and the antibacterial nano material is mixed with a solution of a polymer containing amino groups and a proper amount of an oxidizing agent, so that the double-crosslinking adhesive drug-loaded hydrogel can be rapidly prepared. By adding hydrophilic drugs or drug-loaded nano particles and the like, application of the drug-loaded nano particles in biomedicine is endowed. The drug-loaded hydrogel is simple in preparation process, has good adhesion performance, can quickly release drugs through pH response, can be naturally dissociated after pH response, does not cause damage to tissues, and has the advantage of good biocompatibility.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a pH-responsive double-crosslinked mussel biomimetic adhesion intelligent drug-loading hydrogel and its preparation method and application. Background technique [0002] Hydrogels, which have a cross-linked three-dimensional polymer network structure, have been extensively studied due to their mechanical and chemical similarities to biological tissues. Meanwhile, the remarkable flexibility of hydrogels makes them promising biomedical materials. Hydrogels have many different applications, including carriers for separation media, biotechnology translation, and tissue engineering and drug delivery vehicles, among others. Hydrogels have unique advantages in drug delivery, not only for sustained release of high-dose drugs at pathological tissue sites, but also with negligible systemic toxicity. It is well known that the microenvironment of disease sites is very complex and...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/104A61L2300/404A61L2400/06C08L5/02C08L5/08C08L1/04C08L77/04C08L79/02
Inventor 王云兵胡成
Owner SICHUAN UNIV
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