Preparation method of mussel-imitated contact antibacterial hydrogel for tissue repair

Abstract

The invention discloses a preparation method of mussel-imitated contact antibacterial hydrogel for tissue repair. The preparation method comprises the following steps: adopting methacryl amidated dopamine, anionic monomer and cationic monomer for copolymerization to generate triblock copolymer with opposite charges and mussel-imitated functional groups, doping quaternary ammonium salt modified natural polymer with positive charges into the triblock copolymer to prepare enhanced contact antibacterial ultra-strong polyelectrolyte hydrogel with a semi-interpenetrating network structure. The preparation method disclosed by the invention has the beneficial effects that due to existence of the cationic monomer and natural polymeric modified quaternary ammonium salt, the hydrogel has good antibacterial property; the methacryl amidated dopamine and the surfaces of bacteria generate mutual action to capture the bacteria, so that the antibacterial efficiency of the hydrogel is enhanced; simultaneously, the methacryl amidated dopamine can promote cell adhesion, so that the hydrogel has good cell affinity; in addition, the hydrogel prepared by the invention also has good mechanical property, stable swelling property and self-healing property and can be applied to tissue repair.

Description

Technical field [0001] The invention relates to biological functional materials, in particular to a method for preparing a mussel-like contact antibacterial hydrogel for tissue repair. Background technique [0002] Hydrogel is a kind of highly hydrated material, which can be used in various medical applications, such as drug delivery, tissue engineering, wound filler and as implant coating. At the same time, the hydrated environment can also promote microbial infection; microbial infection can Causes wound surface polymerization damage and biomedical material implantation failure; therefore, in addition to its main functions (such as wound healing, drug release, tissue repair and regeneration, etc.), hydrogels with antibacterial properties are more promising. ; There are two sources for the antibacterial properties of hydrogels: antibacterial agents (such as silver nanoparticles, antibiotics) and the inherent antibacterial properties of the hydrogel network; however, the abuse of...

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Problems solved by technology

[0002] Hydrogels are a class of highly hydrated materials that can be used in various medical applications, such as drug delivery, tissue engineering, wound fillers, and as implant coatings; meanwhile, a hydrated environment can also promote microbial infections; microbial infections can It leads to the damage of wound aggregation and the failure of implantation of biomedical materials; therefore, in addition to its main functional roles (such as wound healing, drug release, tissue repair and regeneration, etc.), hydrogels with antibacterial properties are more promising. ; The antibacterial properties of hydrogels come from two sources: antimicrobial agents (such as silver nanoparticles, antibiotics) and the inherent antibacterial properties of the hydrogel network; however, the abuse of antimicrobial agents can lead to bacterial resistance; currently, the intrinsic antibacterial properties Hydrogels are a research hotspot; intrinsic antibacterial hydrogels can be divided into: antibacterial peptide-based hydrogels, chitosan-based hydrogels and other polymer derivative hydrogels; most quaternary ammonium salt antibacterial hydrogels The antibacterial properties of hydrogel not only rely on antibacterial effect, but also rely on antifouling effect to prevent bacterial adhesion, so as to achieve antibacterial effect, but at the same time it is not conducive to cell adhesion; the cell adhesion and tissue affinity of this type of hydrogel Not good, which limits its application in the field of bioengineering; and when the antibacterial hydrogel is used as an implant in the body, it often needs to have good mechanical properties and stable swelling

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