Aztreonam composition freeze-dried powder for injection
A technology of freeze-dried powder injection and aztreonam, which is applied in the direction of freeze-dried delivery, powder delivery, medical preparations of non-active ingredients, etc., and can solve the problem of no dosage form containing chitosan nanoparticles, large amount of use, and difficulty in mixing Uniformity and other issues, to achieve the effect that is beneficial to clinical application, eliminate active effect, and enhance antibacterial effect
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[0030] Example 1. Preparation of freeze-dried powder injection of aztreonam composition for injection, based on 1000 pieces.
[0031] prescription:
[0032] Aztreonam 250g
[0033] Chitosan Nanoparticles 100g
[0034] Water for injection 2000ml
[0035] 2. Preparation process:
[0036] (1) Weigh 250g of chitosan nanoparticles and slowly add them to 2000ml of water for injection, and stir until dissolved while adding.
[0037] (2) Add 500g of aztreonam and stir to dissolve until clear.
[0038] (3) Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and then filter the drug solution through 0.45μm and 0.22μm microporous membranes for testing The intermediate content is calculated as 0.5g per bottle based on aztreonam.
[0039] (4) Fill according to the inspection requirements, send it to the freeze dryer after half pressure stopper, cool down to -40°C, keep ...
Example Embodiment
[0040] Example 2: Preparation of freeze-dried powder injection of aztreonam composition for injection, based on 1000 pieces.
[0041] 1. Prescription:
[0042] Aztreonam 250g
[0043] Chitosan Nanoparticles 125g
[0044] Water for injection 2000ml
[0045] 2. Preparation process:
[0046] (1) Weigh 250g of chitosan nanoparticles and slowly add them to 2000ml of water for injection, and stir until dissolved while adding.
[0047] (2) Add 500g of aztreonam and stir to dissolve until clear.
[0048] (3) Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and then filter the drug solution through 0.45μm and 0.22μm microporous membranes for testing The intermediate content is calculated as 0.5g per bottle based on aztreonam.
[0049] (4) Fill according to the inspection requirements, send it to the freeze dryer after half pressure stopper, cool down to -40°C, ke...
Example Embodiment
[0050] Example 3: Preparation of freeze-dried powder injection of aztreonam composition for injection, based on 1000 pieces.
[0051] prescription:
[0052] Aztreonam 250g
[0053] Chitosan Nanoparticles 150g
[0054] Water for injection 2000ml
[0055] 2. Preparation process:
[0056] (1) Weigh 300g of chitosan nanoparticles and slowly add them to 2000ml of water for injection, and stir until dissolved while adding.
[0057] (2) Add 500g of aztreonam and stir to dissolve until clear.
[0058] (3) Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and then filter the drug solution through 0.45μm and 0.22μm microporous membranes for testing The intermediate content is calculated as 0.5g per bottle based on aztreonam.
[0059] (4) Filling according to the inspection requirements, sending it into the freeze dryer after half-pressing stopper, and leaving the b...
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