The present invention relates to a thermoplastic foaming polyurethane fiber board, a production method and uses thereof. The thermoplastic foaming polyurethane fiber board comprises an A surface layer, a B middle layer and a C bottom layer, wherein the A surface layer, the B middle layer and the C bottom layer are integratedly compounded from top to bottom, the A surface layer is a sheet material prepared by carrying out mixing calendaring on a TPU resin, a filler, a fire retardation agent, a stabilizer, a lubricant and a colorant according to a certain ratio, the B middle layer is a layer prepared by foaming the sheet material prepared by carrying out mixing calendaring on a TPU resin, a filler, a fire retardation agent, a stabilizer, a lubricant and a colorant according to a certain ratio, and the C bottom layer is a layer prepared by drying a fiber cloth impregnated with a TPU composition. The thermoplastic foaming polyurethane fiber board can be used as flooring boards, wall panels, roof hanging plates and indoor partition boards, and can be used for production of furniture materials and various building materials.