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Super-hydrophilic coating with long-acting antibacterial property and preparation method thereof

A super-hydrophilic and high-performance technology, used in coatings, pharmaceutical formulations, and devices for coating liquids on surfaces. Fouling performance and bactericidal performance, excellent antioxidant and oxygen free radical scavenging, good antibacterial effect

Active Publication Date: 2018-11-16
JILIN VENUS HAOYUE MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For wound dressings, its antibacterial performance is not long-lasting, and it cannot achieve long-term antibacterial function on the wound site

Method used

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  • Super-hydrophilic coating with long-acting antibacterial property and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of superhydrophilic coating with long-acting antibacterial performance, its preparation method comprises the following steps:

[0026] (1) Polishing, cleaning and drying medical stainless steel materials;

[0027] (2) placing the treated base material in an acetic acid-sodium acetate buffer solution with a pH value of 4, then adding gallic acid, L-arginine, silver nitrate and concentrated nitric acid with a mass fraction of 65%-68%, The final concentrations of gallic acid, L-arginine, silver nitrate and concentrated nitric acid were 0.01mg / mL, 0.01mg / mL, 0.01mg / mL and the mass fraction was 34%, respectively, and then reacted at 40°C for 30h;

[0028] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

Embodiment 2

[0030] A kind of superhydrophilic coating with long-acting antibacterial performance, its preparation method comprises the following steps:

[0031] (1) polishing, cleaning and drying the nickel-titanium alloy material;

[0032](2) Place the treated base material in a phthalic acid-hydrochloric acid buffer solution with a pH value of 3.5, then add epigallocatechin gallate (EGCG), ethylenediamine, zinc chloride and mass fraction 30% hydrogen peroxide solution, the final concentrations of epigallocatechin gallate (EGCG), ethylenediamine, zinc chloride and 30% hydrogen peroxide solution were 1 mg / mL, 2 mg / mL, respectively. mL, 1mg / mL and 15% mass fraction, then react at 30°C for 10h;

[0033] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

Embodiment 3

[0035] A kind of superhydrophilic coating with long-acting antibacterial performance, its preparation method comprises the following steps:

[0036] (1) cleaning and drying the polytetrafluoroethylene material;

[0037] (2) Place the treated base material in 2-(N-morpholine)ethanesulfonic acid buffer solution with a pH value of 6, then add epicatechin gallate (ECG), 1,8-diamino Octane, copper chloride and sodium periodate solutions, the final concentrations of epicatechin gallate (ECG), 1,8-diaminooctane, copper chloride and sodium periodate solutions were 2 mg / mL , 4mg / mL, 2mg / mL and 4mg / mL, then react at 15°C for 24h;

[0038] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

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Abstract

The invention provides a super-hydrophilic coating with a long-acting antibacterial property and a preparation method thereof. The preparation method comprises the following steps that the surface ofa substrate material is pretreated; the pretreated substrate material is put into a slight acidic buffer solution, then a polyphenolic substance, a multi-amine compound, an antibacterial agent and anoxidizing agent are added to react; a reaction product is immersed in deionized water, ultrasonic cleaning is carried out, then drying is carried out under a nitrogen condition to prepare the coating.The super-hydrophilic coating with the long-acting antibacterial property and the preparation method thereof have the advantages that the operation is simple, the reaction condition is mild; the prepared coating material contains the polyphenolic substance, and a large number of carboxyl, phenolic hydroxyl group, quinonyl, amidogen and other functional groups and metal ions or agents which has the antibacterial property, so that the metal ions and the antibacterial agents achieve the long-term existence of the antibacterial agent through the mutual effect with the phenolic hydroxyl group function group or the accumulation of a pi-pi system. The coating can be applied to the preparation of wound dressing materials in the field of medical materials.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a superhydrophilic coating with long-acting antibacterial properties and a preparation method thereof, which can be used to prepare wound dressings and implanted device surface protection materials with antibacterial functions. Background technique [0002] Bacterial infection is common in clinically implanted devices. Although aseptic treatment of implanted devices has reduced the degree of bacterial infection to a certain extent, according to literature reports, there are still 4% to 6% of patients in the early stage of implantation. Implant failure due to pathogen infection. According to statistical analysis, 80% of patients fail because of bacterial infection. Because during the corresponding surgical treatment, due to the long-term exposure of the patient's tissues or organs to the open environment, the chance of contact with pathogenic bacteria increa...

Claims

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Application Information

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IPC IPC(8): B05D1/18B05D3/00B05D5/00B05D7/24A61L31/08A61L31/16A61L31/14A61L15/20A61L15/18A61L15/44A61L15/46
CPCA61L15/18A61L15/20A61L15/44A61L15/46A61L31/08A61L31/14A61L31/16A61L2300/102A61L2300/104A61L2300/208A61L2300/406A61L2400/18B05D1/18B05D3/002B05D3/007B05D5/00B05D7/24
Inventor 王云兵李林华罗日方李高参
Owner JILIN VENUS HAOYUE MEDICAL LTD
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