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Substrate surface modification method for anti-insulin adhesion

A technology for anti-insulin and substrate surface, applied in the field of substrate surface modification for anti-insulin adhesion, can solve the problems of easy accumulation in the body, impossibility of popularization, complex methods, etc., achieve high economic value, easy to repeat implementation, and simple method easy effect

Inactive Publication Date: 2019-04-09
浙江省医疗器械研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the added amphiphilic small molecules will enter the human body along with the liquid medicine and easily accumulate in the body, bringing unknown risks to patients, so it cannot be promoted
[0004] The invention patent application with the application number 200910060489.0 discloses a plastic whose surface has been modified for anti-protein adsorption. The carboxymethylated derivative of fungal pachymane polysaccharide is linked to the surface of the plastic substrate by covalent bonds to achieve the effect of anti-protein adhesion. The method is aimed at devices implanted in the human body, and the base material is polyurethane. The method is too complicated and the cost is high

Method used

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  • Substrate surface modification method for anti-insulin adhesion
  • Substrate surface modification method for anti-insulin adhesion

Examples

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Effect test

Embodiment 1

[0020] The substrate surface modification method of anti-insulin adhesion of the present invention comprises the following steps:

[0021] 1) Soak the cleaned substrate in dopamine hydrochloride (DOPA) solution for 12 hours, take it out, wash it with deionized water and dry it, the concentration range of dopamine hydrochloride solution is 8mg / mL;

[0022] 2) Soak the substrate in polyethyleneimine (PEI) solution for 30 minutes, take it out, wash it with deionized water and dry it, the concentration range of polyethyleneimine solution is 4mg / mL;

[0023] 3) Soak the substrate in 2-methacryloyloxyethyl phosphorylcholine (MPC) solution for 12 hours, take it out, wash it with deionized water and dry it, 2-methacryloyloxyethyl The concentration range of phosphorylcholine solution is 10mg / mL. The pH range of polyethyleneimine solution is 10.

[0024] In this embodiment, the substrate is made of polypropylene (it can also be made of other plastic materials such as PVC, but PP is pr...

Embodiment 2-6

[0026] In embodiment 2-6, each parameter and anti-adhesion effect are shown in the table below

[0027]

[0028] Table 1

Embodiment 7-10

[0030] In this group of examples, a pretreatment step (1-0) is performed before step (1): ultrasonically treat with acetone, methanol, and triple-distilled water for 10 minutes, and finally wash with triple-distilled water, dry, and store spare. In order to prevent oxidation, the deionized water in steps (1) to (3) is provided by an ultrapure water machine, and the drying process is completed by blowing high-purity nitrogen. In embodiment 7-10, each parameter and anti-adhesion effect are shown in the following table:

[0031]

[0032] Table 2

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Abstract

The invention provides an insulin adherence-resistant base surface modification method. The method comprises 1, immersing a cleaned base in a dopamine hydrochloride solution for 2-24h, taking out the base, washing the base through deionized water and carrying out air drying, 2, immersing the base in a polyethyleneimine solution for 2-60min, taking out the base, washing the base through deionized water and carrying out air drying, and 3, immersing the base in a 2-methacryloyloxyethyl phosphorylcholine solution for 2-24h, taking out the base, washing the base through deionized water and carrying out air drying. Through DOPA surface polymerization mediated PEI adsorption and further fixing of MPC, insulin adherence is effectively prevented. The method is simple and easy, has defined and controllable process parameters and is convenient for repeated implementation for large scale production.

Description

technical field [0001] The invention relates to the field, and specifically refers to a method for modifying the surface of a base material that resists insulin adhesion. Background technique [0002] Protein drugs have attracted much attention because of their high activity, strong specificity, low toxicity, few side effects, clear biological functions, and favorable clinical application. However, its source is rare, expensive, and highly effective, and the concentration reduction and fluctuations caused by the adsorption of the container wall usually bring troubles to the effective utilization of the drug. Experiments and clinics have repeatedly proved that the loss rate of insulin and other protein drugs can be as high as 70% due to adsorption on the wall of the device during storage and use, which not only causes a great waste of medical resources, but also greatly reduces the efficacy of the drug; moreover The drug concentration fluctuations caused by the adsorption on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08J7/16C08L23/12
CPCC08J7/12C08J7/16C08J2323/12
Inventor 曾叶
Owner 浙江省医疗器械研究所
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