Chiral supermolecule hydrogel and preparation method and application thereof

A supramolecular hydrogel and chiral technology, applied in the field of medicine or tissue engineering, can solve the problems of no biological activity, expensive preparation cost, pathogenicity, etc., and achieve easy mass industrial production, convenient operation, dispersion good sex effect

Inactive Publication Date: 2014-04-02
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Artificial tissues and organs commonly used in medicine are not biologically active, some are even pathogenic,

Method used

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  • Chiral supermolecule hydrogel and preparation method and application thereof
  • Chiral supermolecule hydrogel and preparation method and application thereof
  • Chiral supermolecule hydrogel and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0036] This embodiment relates to a chiral supramolecular hydrogel, the chiral supramolecular hydrogel is a phenylalanine derivative with a 1,4-benzene ring as the nucleus, and the structural formula of the derivative is as follows:

[0037]

[0038] Among them, R 1 for H

[0039] R 2 is COOEtOEtOH.

[0040] This embodiment also relates to the preparation method of the aforementioned chiral supramolecular hydrogel, the method comprising:

[0041] Step 1, get terephthaloyl chloride, L-phenylalanine methyl ester hydrochloride, triethylamine; The ratio is 1:2:6; the raw materials can be obtained from open commercial channels;

[0042] Step 2: Cool 10-40 mL of anhydrous dichloromethane solution of L-phenylalanine methyl ester hydrochloride to 0°C, add triethylamine, and then add 5-10 mL of terephthaloyl chloride to obtain a reaction solution ; The reaction solution was slowly raised to room temperature and stirred for 12 to 16 hours;

[0043] Step 3: Rotate the reaction s...

Embodiment 2

[0048] This embodiment relates to a chiral supramolecular hydrogel, the chiral supramolecular hydrogel is a phenylalanine derivative with a 1,4-benzene ring as the nucleus, and the structural formula of the derivative is as follows:

[0049]

[0050] Among them, R 1 is COOEtOEtOH,

[0051] R 2 for H.

[0052] This embodiment also relates to the preparation method of the aforementioned chiral supramolecular hydrogel, the method comprising:

[0053] Step 1, get terephthaloyl chloride, L-phenylalanine methyl ester hydrochloride, triethylamine; The ratio is 2:3:4; the raw materials can be obtained from open commercial channels;

[0054] Step 2: Cool 10 mL of anhydrous dichloromethane solution of L-phenylalanine methyl ester hydrochloride to 0° C., add triethylamine, and then add 5 mL of terephthaloyl chloride to obtain a reaction solution; Slowly warm to room temperature and stir for 12 hours;

[0055] Step 3: Rotate the reaction solution, add 10 mL of deionized water, an...

Embodiment 3

[0060] This embodiment relates to a chiral supramolecular hydrogel, the chiral supramolecular hydrogel is a phenylalanine derivative with a 1,4-benzene ring as the nucleus, and the structural formula of the derivative is as follows:

[0061]

[0062] Among them, R 1 is COOEtOEtOH,

[0063] R 2 for H.

[0064] This embodiment also relates to the preparation method of the aforementioned chiral supramolecular hydrogel, the method comprising:

[0065] Step 1, get terephthaloyl chloride, L-phenylalanine methyl ester hydrochloride, triethylamine; The ratio is 2:3:4; the raw materials can be obtained from open commercial channels;

[0066] Step 2: Cool 10 mL of anhydrous dichloromethane solution of L-phenylalanine methyl ester hydrochloride to 0° C., add triethylamine, and then add 5 mL of terephthaloyl chloride to obtain a reaction solution; Slowly warm to room temperature and stir for 12 hours;

[0067] Step 3: Rotate the reaction solution, add 10 mL of deionized water, an...

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Abstract

The invention provides a chiral supermolecule hydrogel and a preparation method and application thereof. The structural formula of the chiral supermolecule hydrogel is shown in the specification, wherein R1 is H or COOEtOEtOH, and R2 is H or COOEtOEtOH. The invention also relates to the preparation method and application of the chiral supermolecule hydrogel. The chiral supermolecule hydrogel can be used as a cytoskeleton material; the process of regulating and controlling the cell selective adhesion by the chiral supermolecule hydrogel is carried out in physiological environment and is convenient to operate; the chiral supermolecule hydrogel has practical application value; the preparation method does not need complicated synthesis steps and is beneficial for large scale industrial production; the prepared product has high purity and good dispersibility, and is applicable to cell culture and controllable adhesives in commerce.

Description

technical field [0001] The invention belongs to the field of medicine or tissue engineering, in particular to a chiral supramolecular hydrogel and its preparation method and application. Background technique [0002] Human tissue damage and defect will lead to dysfunction. The traditional repair method is autologous tissue transplantation. Although it can achieve satisfactory curative effect, it is at the expense of autologous healthy tissue, which will lead to many complications and the source of extra body organs is extremely difficult. Limited, long-term use of immunosuppressants is required due to immune rejection, and the resulting complications are sometimes fatal. According to incomplete statistics, every year, many people suffer from skin burns, damaged corneas, or broken bones, which not only bring pain to the victims, but also seriously affect their daily life. Therefore, tissue regenerative medicine has become a major problem that urgently needs to be solved at h...

Claims

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Application Information

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IPC IPC(8): C07C233/87C07C231/12A61L27/00A61L27/52C12N5/071
Inventor 冯传良刘国锋
Owner SHANGHAI JIAO TONG UNIV
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