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Carbon quantum dot-copper ion fluorescent probe and preparation method and application thereof

A technology of carbon quantum dots and fluorescent probes, which is applied in the field of nanomaterial preparation, can solve problems such as electrode oxidation, carbon quantum dot stability damage, and limitations, and achieve low cost, simplified experimental conditions and difficulty, and improved application effects

Active Publication Date: 2018-01-12
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the continuous current has damage to the stability of carbon quantum dots, and the oxidation reaction that occurs is easy to oxidize the electrode. Therefore, the practical application of electrochemical detection of glucose stability has been severely limited, and it has plagued many researchers.

Method used

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  • Carbon quantum dot-copper ion fluorescent probe and preparation method and application thereof
  • Carbon quantum dot-copper ion fluorescent probe and preparation method and application thereof
  • Carbon quantum dot-copper ion fluorescent probe and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Example 1 A novel fluorescent probe based on carbon quantum dots-copper ions

[0032] (1) Preparation method

[0033] 1. Preparation of carbon quantum dots (CQDs) solution

[0034] Use the ultrapure water machine UP to take ultrapure water, mix 0.1g citric acid, 0.1g urea with 40mL ultrapure water, transfer it to the reaction kettle, put it in an explosion-proof film, seal it, and place it in a microwave hydrothermal synthesizer. Set the power to 1000W, the pressure to 1.5MPah, and heat in four stages. In the first stage, heat up to 120°C and heat for 15-20min; in the second stage, heat up to 150°C and heat for 15-20min; in the third stage, heat up Heat to 180°C for 15-20min; in the fourth stage, raise the temperature to 210°C and heat for 2h to obtain a brown suspension. Put the brown suspension in a fume hood and let it stand, cool to room temperature, first filter it with a Buchner funnel (filter paper diameter: 15-20 μm), filter out bulky substances, and take the ...

Embodiment 2

[0052] Example 2 Application of carbon quantum dot-copper ion fluorescent probe in non-enzymatic detection of glucose

[0053] (1) prepare glucose (C 6 h 12 o 6 ) solution

[0054] Weigh 3.567g of glucose, dissolve it in a beaker filled with 400mL of ultrapure water, put it on a magnetic stirrer and stir evenly for 10.00min, drain it with a glass rod and pour it into a 500mL volumetric flask, add ultrapure water to volume, and get The concentration is 36mM glucose stock solution, and it is stored in a dark place away from light for use.

[0055] (2) Under different pH conditions, the effect of the same concentration of glucose solution on CQDs / Cu 2+ The influence of the fluorescence intensity of the system

[0056] Get the Cu prepared in Example 1 respectively 2+ Carbon quantum dots-copper ion-based fluorescent probe CQDs / Cu at a concentration of 1000 μM 2+ Solution 2mL in a test tube. To CQDs / Cu 2+ Add 2 mL of glucose solution with a concentration of 1000 μM to the s...

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Abstract

The invention relates to a carbon quantum dot-copper ion fluorescent probe and a preparation method and application thereof. The method includes that carbon quantum dots with strong fluorescence are synthesized by the aid of a microwave hydrothermal method, fluorescence strength of the carbon quantum dots are greatly reduced by the aid of copper ions, the copper ions are composited on surfaces ofthe carbon quantum dots, surface energy is transferred, CQDs / Cu<2+> with weak fluorescence is formed, a glucose solution is added, pH value is adjusted to 7, heating is performed at the temperature of80DEG C, glucose and the copper ions undergo 'copper mirror reaction' to be oxidized to gluconic acid, and the copper ions are reduced to be precipitated to be Cu2O2. The fluorescence spectrum test shows that after the glucose solution is added, glucose is catalyzed and oxidized through the copper ions on the carbon quantum dots CQDs for reaction and is removed from surfaces of the CQDs, and thestrong fluorescence on the CQDs is restored. The carbon quantum dot-copper ion fluorescent probe based CQDs / Cu<2+> is applicable to effective detection of the glucose under non-enzymatic environment.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a water-soluble carbon quantum dot-copper ion fluorescent probe prepared by using citric acid as a carbon source and urea as a nitrogen source by a microwave hydrothermal synthesis method, and its rapid non-enzymatic Applications in the detection of glucose in the environment. Background technique [0002] With the rapid economic development and the acceleration of the industrialization process, as well as the changes in the lifestyle and the acceleration of the aging process, the prevalence of diabetes in my country is on the rise, and it has become another serious hazard to the people after cardiovascular and cerebrovascular diseases and tumors. Health important chronic non-communicable diseases. According to WHO estimates, from 2005 to 2015, the economic loss caused by diabetes and related cardiovascular diseases in China reached 557.7 billion US d...

Claims

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Application Information

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IPC IPC(8): C09K11/65B82Y20/00B82Y30/00B82Y40/00G01N21/64
Inventor 宋有涛刘冠宏任佩佩王君杨帆李欣屹于志月
Owner LIAONING UNIVERSITY
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