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Copper sulphide@mesoporous silica nanocomposite and preparation method and application thereof

A technology of mesoporous silica and nanomaterials, applied in the direction of nanotechnology, nanotechnology, wave energy or particle radiation treatment materials, etc., can solve the harsh conditions of preparation and functionalization, affect the stability of photothermal performance, and shape Easy to change and other problems, to achieve the effect of high photothermal conversion efficiency, low cost, and wide application range

Active Publication Date: 2017-09-22
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gold (gold nanorods, gold nanocages) and platinum (platinum nanosheets) nanomaterials are used in photothermal therapy due to their surface tunable surface plasmon effect, but because they are noble metal materials and their morphology is prone to occur after heating changes, thereby affecting the stability of the photothermal performance, further limiting their applications
Carbon (graphene, carbon nanorods) is used in photothermal therapy due to its stable photothermal performance, but its photothermal application is inhibited due to its low light absorption coefficient and harsh conditions for its preparation and functionalization.
Organic photothermal materials (indocyanine green, polypyrrole nanomaterials) have good prospects for photothermal applications due to their biodegradable properties, but they are prone to photodegradation after prolonged laser irradiation, which also greatly reduces their utilization rate of

Method used

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  • Copper sulphide@mesoporous silica nanocomposite and preparation method and application thereof
  • Copper sulphide@mesoporous silica nanocomposite and preparation method and application thereof
  • Copper sulphide@mesoporous silica nanocomposite and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of copper sulfide / silica nanoparticles

[0039] (1) Synthesis of mesoporous silica nanomaterials with mercapto groups on the surface;

[0040] Mix 64mL water, 11.25mL ethanol, 0.2g diethanolamine and 10.4mL cetyltrimethylammonium chloride aqueous solution (25wt%), stir the reaction at 60°C for 0.5h, then add 7mL tetraethoxysilane And 0.6mL mercaptopropyltrimethoxysilane, continue to stir the reaction for 3h. After the reaction is completed, centrifuge and wash 2-5 times with a mixture of ethanol and water, then slowly add 15mL of concentrated hydrochloric acid into 120mL of ethanol solution to form a mixed solution, and let the above-mentioned reaction product be dispersed in the mixed solution. Stir and react at 60° C. for 24 h, and finally, centrifuge and wash 2-5 times with a mixture of ethanol and water. The SEM graphics obtained from the test are as follows figure 1 As shown, the TEM pattern is as figure 2 As shown, it can be seen that the particle...

Embodiment 2

[0045] Photothermal Properties of Copper Sulfide Modified Silica Composite Nanomaterials

[0046] The CuS@mSiO obtained in Example 1 2 The material is formulated into solutions of different concentrations (0, 12, 24, 60, 100 and 120ppm), and the laser is used at 980nm with 0.72W / cm 2 The power of light is irradiated for 5 minutes, and the obtained temperature curves of different concentrations of materials are as follows: Figure 7 Shown, 120ppm concentration of CuS@mSiO 2 The light stability diagram of the material is shown in Figure 8 shown.

[0047] from Figure 7 with Figure 8 It can be seen that the prepared CuS@mSiO 2 The material has obvious photothermal function. With the prolongation of the light time, the temperature rise of the material is more obvious, and it has a certain photothermal stability. According to Roper's method to calculate the light-to-heat conversion efficiency, it can be known that the light-to-heat conversion efficiency is 27.4%.

Embodiment 3

[0049] Preparation of copper sulfide / silica nanoparticles (copper chloride + sodium thiosulfate)

[0050] (1) Synthesis of mesoporous silica nanomaterials with mercapto groups on the surface;

[0051] This process is exactly the same as step (1) in Example 1.

[0052] (2) Synthesis of Copper Sulfide Modified Mesoporous Silica Composite Nanomaterials - Heating Reflux Method

[0053] Take 20 mg of the above sample and disperse it in 20 mL of water, adjust the pH of the solution to 7.5, stir for 20 minutes, add 200 μL of 0.1M copper chloride solution, stir for 5 hours, add 100 μL of 0.2M sodium thiosulfate solution drop by drop, at 100 Refluxed at ℃ for 7h to obtain the target product. The SEM graphics obtained from the test are as follows Figure 9 shown.

[0054] from Figure 9 It can be seen from the figure that the particle structure of the copper sulfide-modified mesoporous silica composite nanomaterial obtained by this method is slightly damaged compared with the exper...

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Abstract

The invention belongs to the technical field of nanometer material preparation technology and special materials, and particularly relates to preparation of a mesoporous silica nanocomposite with the photo-thermal function and photo-thermal performance research thereof. According to the mesoporous silica nanocomposite, cetyl trimethyl ammonium chloride is adopted as a template, tetraethoxy-silicane is adopted as a silicon source, trithione propyl trimethoxy silane is adopted as a sulfydryl modifier, and the mixture is stirred under the temperature of 60 DEG C to perform a reaction to form meso-porous silicon balls; then, the obtained sample is dispersed into water, a copper ion saline solution is added into the alkaline condition, stirring continues to be performed, then, cupric ions are adsorbed, then, sodium sulfide or sodium thiosulfate water solution is added on the acid condition, and stirring is performed to obtain the mesoporous silica nanocomposite modified by copper sulfide. The meso-porous silicon balls with the photo-thermal treatment function have the advantages of being small in particle size, high in specific surface, large in capacity, good in biocompatibility and the like, and the preparation method has the technical advantages of being simple in technology, low in cost, high in photo-thermal conversion efficiency, wide in application range and the like.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation technology and special material technology, and specifically relates to a kind of mesoporous silica nanomaterial with photothermal function and its preparation and photothermal performance research. This material will have important applications in tumor photothermal therapy . Background technique [0002] In recent centuries, cancer has become one of the main factors threatening human life. At present, the treatment methods for cancer mainly include traditional surgical resection, chemotherapy, radiotherapy, traditional Chinese medicine treatment, etc., but these treatments still have shortcomings, such as killing cancer cells and normal cells at the same time, and have certain effects on the immune system. Destruction, side effects are relatively large, and may even cause secondary cancer in the body. Therefore, it is urgent to find new ways to effectively and completely treat cancer. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61K49/00A61P35/00B82Y30/00
CPCA61K41/0052A61K47/02A61K49/00B82Y30/00
Inventor 刘湘梅韩艺蕃田康赵强黄维刘淑娟
Owner NANJING UNIV OF POSTS & TELECOMM
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