Purrocoline derivative and synthetic method and application thereof

Abstract

The invention discloses a purrocoline derivative and a synthetic method and application thereof. The purrocoline derivative with a novel structure can be prepared by reacting propargyl alcohol and a 2-alkyl pyridine compound by taking samarium trifluoromethanesulfonate as a catalyst under the condition without a solvent; the reaction consumption and the chemical contamination are reduced, the cost is reduced and the operation is simplified; the obtained purrocoline derivative has better activity on a gastric cancer cell strain MGC80-3. The structural formula of the purrocoline derivative is shown in a formula (I) in the specification, wherein R<1> is phenyl, 4-methoxyphenyl, 4-fluorophenyl and 2-chlorphenyl or thienyl, R<2> is phenyl, and R<3> is H, phenyl, methyl, a nitrile group or an ethyl acetate group.

Description

technical field

[0001] The invention relates to the technical field of medicinal chemistry, in particular to a series of indolizine derivatives and their synthesis methods and applications. Background technique

[0002] Malignant tumor is one of the major diseases that seriously threaten human health. Every year, 11 million people are diagnosed with cancer worldwide. It has become the second leading cause of death after cardiovascular and cerebrovascular diseases. At present, in the method of treating cancer, chemical drug therapy is a research field with the fastest development. Among them, natural indolizine compounds are known for their anti-virus, anti-tumor, anti-inflammatory, anti-fungal, anti-Leishmania, Various biological activities such as anti-oxidation, histamine H3 receptor antagonism and immune regulation have attracted more and more attention from researchers. However, due to its low natural content and difficulty in separation and purification, it has brought ...

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