1,2,3-trisubstituted indolizine derivative and preparation method thereof

An indolizine derivative and tri-substitution technology, which is applied in the field of 1,2,3-trisubstituted indolizine derivatives and their preparation, can solve the problems of fast forward and reverse reactions, harsh conditions, complex reactions, etc., and achieves energy reduction. The effect of low consumption, mild reaction conditions and high reaction yield
CN108530442AInactive Publication Date: 2018-09-14ANHUI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ANHUI NORMAL UNIV
Publication Date
2018-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to an indolizine derivative, and specifically discloses a 1,2,3-trisubstituted indolizine derivative and a preparation method thereof, wherein the chemical structure formula of the indolizine derivative is I as shown in the specification. The 1,2,3-trisubstituted indolizine derivative has benzoyl groups at both 1 and 3 positions, and an ester group at 2-position, namely, the 1,2,3-trisubstituted indolizine derivative has substituents containing carbonyl groups, benzene rings and the ester group, and further modification and processing of the product structure arefacilitated by the chemical nature of the benzoyl groups and the ester group, and more possibilities are provided for the construction of more complex indolizine derivatives. Moreover, the preparationmethod of the 1,2,3-trisubstituted indolizine derivative does not require addition of a metal catalyst, does not require inert gas protection, and has the advantages of easy-to-obtain reaction raw materials, high reaction yield, and mild reaction conditions.
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Description

technical field

[0001] The invention relates to indolizine compounds, in particular to a 1,2,3-trisubstituted indolizine derivative and a preparation method thereof. Background technique

[0002] Indolizine compounds are a class of very useful compounds that are widely used in the fields of medicine, organic light-emitting materials and organic synthesis. Indolizine is a heterocyclic compound consisting of a five-membered and six-membered fused ring and a bridgehead nitrogen atom. It exhibits excellent properties in many biological activities and can be used as various inhibitors and antiviral, antibacterial, antibacterial, and antibacterial agents. Drugs such as tumors; in addition, indolizine derivatives are key intermediates for the synthesis of a class of alkaloids with physiological activity, and complex molecules containing indolizine skeletons can also be found in natural product molecules isolated and extracted from some plants and marine organisms . In addition, i...

Claims

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