100results about How to "Reduce polymerization" patented technology

The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

The present invention relates to bone cements and, more particularly, to multi-solution bone cements and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, thereby providing for a significant increase in the polymer-to-monomer (P:M) ratio. Another embodiment of the present invention provides cross-linked PMMA beads which are surface modified with unsaturated carbon double bonds. A further embodiment of the present invention provides multi-solution bone cements made with PMMA-PMMA spherical brush polymers.

An applicator tip for an applicator for applying a polymerizable monomeric adhesive composition can include a bioactive material, a flavorant, a polymerization initiator, and/or a polymerization rate modifier.

The present invention discloses an injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and a preparation method thereof, and belongs to the field of organic functional materials preparation. The polymethyl methacrylate-based composite scaffold bone transplant material uses polymethyl methacrylate (PMMA) as a scaffold for providing mechanical supporting, and a chitosan-based thermosensitive hydrogel as a pore forming agent and an osteoconductive material and a drug carrier, and the polymethyl methacrylate (PMMA) and the chitosan-based thermosensitive hydrogel are mixed with each other to form an injectable-porous three-dimensional structural bone cement composite. The scaffold bone transplant material is simple in preparation method, suitable in reaction temperature, and good in biocompatibility, has matched mechanical properties, good biological mineralization and corresponding anti-bacterial, anti-inflammatory or anti-tumor capabilities, and has broad prospects in clinical application of reconstruction of bone tissues in future.

A method for hydrosilylating a vinyl-substituted aromatic compound comprising reacting a hydrido (hydrocarbonoxy)silane compound with the vinyl-substituted aromatic compound in the presence of a platinum or platinum compound catalyst and a carboxylic acid. The presence of the carboxylic acid increases the positional selectivity of addition in the hydrosilylation reaction and reduces the polymerization of vinyl groups even in the case of a high-temperature or long-term hydrosilylation reaction.

The invention discloses a preparation method of a nickel-molybdenum clad layer. The method comprises the following steps of: dissolving heteropolymolybdate, fluoride, a complexing agent and chloride into water, and regulating the pH value of a solution with sodium carbonate to obtain a plating solution containing the heteropolymolybdate, fluoride, complexing agent and chloride of the pH value 3-6; and putting a pretreated plating piece to be plated serving as a cathode and a nickel plate serving as an anode into the plating solution containing the heteropolymolybdate, fluoride, complexing agent and chloride of the pH value 3-6 for plating, flushing the plating piece with water, and drying in the air to obtain a plating piece which contains a nickel-molybdenum clad layer on the surface. The hardness of the finally-obtained nickel-molybdenum clad layer is increased remarkably, the thermal expansion coefficient falls, the final hardness is 550-600 HV, and the thermal expansion coefficient is 13*10<-6>-5.2*10<-6> K<-1>.

The invention discloses a preparation method of guerbet alcohol. In this method, nano-scale metal oxides are taken as catalysts, strong alkaline substances are taken as cocatalysts, and fatty alcohol is catalyzed and condensed with one water molecule removed at nitrogen atmosphere to obtain the guerbet alcohol. The invention is characterized in that the reaction time is short, the highest yield is up to 92%, the product purity is greater than 96%, and the product selectivity is high (the content of trimers in product is less than 2.5%).

The invention relates to method for widening catalytic reforming feedstock. The comprises the following steps: mixing FCC (fluid catalytic cracking) stabilized gasoline and straight-run naphtha in a ratio of (50:50) to (70:30), filtering the obtained mixture by a feedstock filter so as to remove impurities in the mixture, and then removing the water carried in the mixed naphtha by a coalescer; mixing the mixed naphtha with hydrogen, and heating the obtained mixture to a reaction temperature by a heating furnace, then feeding the obtained mixture into a hydrogenation reactor to contact with a hydrogenation catalyst so as to be subject to olefin saturation, desulphurization and denitrification reactions; and condensating and cooling the obtained hydrogenation effluent, then separating the obtained product so as to obtain hydrogen-rich gas and hydrogenated gasoline, recycling the hydrogen-rich gas, and feeding the hydrogenated gasoline into an evaporation tower to be subject to strippingfractionation, thereby obtaining a refined naphtha meeting the reforming feeding requirements. By utilizing the method provided by the invention, the mixed naphtha containing more than 50 percent of the FCC stabilized gasoline can be subject to hydroprocessing so as to obtain the refined naphtha, wherein the content of the impurities in the refined naphtha satisfies the reforming feeding requirements, thereby solving the shortage problem of the reforming feedstock, and widening the source of the reforming feedstock.

The invention discloses a method for preparing high-purity dicyclopentadiene (DCPD). The method comprises the steps of adding a diluting agent into crude dicyclopentadiene serving as a raw material during depolymerization, mixing dicyclopentadiene with the diluting agent in a ratio of 0.5-5, and then putting the mixture into a depolymerization rectifying tower, wherein at a normal pressure, the depolymerization temperature is 160-200 DEG C, the reflux ratio is 0.5-5, and the depolymerization time is 1-3 hours; obtaining high-purity cyclopentadiene (CPD) from the top of the tower, putting the cyclopentadiene into a tubular reactor to finally obtain dicyclopentadiene of which the purity is more than 99%, wherein the reaction temperature is 40-120 DEG C, the reaction pressure is 0.1-1.5MPa, and the residence time is 4-10 hours. The method disclosed by the invention has obvious beneficial effects, can reduce polymerization reaction of the crude dicyclopentadiene during depolymerization, and can improve the yield of the dicyclopentadiene; meanwhile, the diluting agent can ensure that impurities including isopropenyl norbornene and the like can be depolymerized, and the purity of dicyclopentadiene is improved, so that the method is particularly suitable for preparing high-purity dicyclopentadiene from the raw material of crude dicyclopentadiene which is obtained through pyrolysis C5 thermal dimerization separation.

The invention discloses a separation purification method of azelaic acid, belonging to the separation purification technical field of organic compound, which comprises depressurizing and distilling the oxidation solution obtained by treating ozonation-oxidation decomposition on unsaturated fatty acid to remove solvent and pelargonic acid, transferring left oxidation solution to a film evaporator to be distilled to obtain crude azelaic acid, extracting and recrystallizing the crude azelaic acid to obtain azelaic acid crystal. In the recrystallization of azelaic acid, the low-carbon dibasic acid of C<4>-C<8> in azelaic acid is dissolved in cold water, to be discharged along with crystallization mother liquor, and the left azelaic acid in the recrystallization mother liquor is recovered by the film separator. The obtained azelaic acid is transferred to a rising film evaporator to be dried and dehydrated and the dehydrated azelaic acid is evaporated by film to obtain the azelaic acid. The whole process can confirm the yield of azelaic aicd and obtain high-quality azelaic acid, while the whole system is sealed and the process has better environmental compatibility.

The invention provides a method for producing a hexamethylenediamine key intermediate 6-aminocapronitrile by a continuous gas-phase two-step method. The method comprises the following steps: S1, mixing caprolactam and water in a gas phase state to carry out continuous hydrolysis or mixing caprolactam and ammonia water in a gas phase state to carry out continuous hydrolysis ammoniation reaction toobtain a first product system containing 6-aminocaproic acid, 6-aminocaproic acid ammonium salt and/or 6-aminocaproamide; and S2, carrying out continuous gas-phase catalytic ammoniation and dehydration reaction on the first product system and ammonia gas to obtain a second product system containing 6-aminocapronitrile. According to the patent of the invention, the problem that water generated by reaction in a one-step process promotes polymerization reaction of the raw material caprolactam is reduced from the source, and the selectivity of aminocapronitrile is improved; and the problems of catalyst deactivation and pressure drop rise caused by polymerization and coking of caprolactam in the reactor are effectively reduced, the stability of the device is improved, and the service life of the catalyst is prolonged.

A method is provided for obtaining highly pure 1,6-hexanediol in which the contents of impurities such as 1,4-cyclohexanediol, 1,5-hexanediol, 1,2-cyclohexanediol, 1,7-pentanediol, 1,5-pentanediol and high boiling point components are significantly reduced.

This process for producing 1,6-hexanediol from cyclohexane comprises the steps of:

• • (1) treating an aqueous extraction concentrate of a reaction mixture obtained by oxidation of cyclohexane with a lower alcohol to esterify monocarboxylic acids and dicarboxylic acids contained in the extract, and simultaneously remove and separate by distillation water, excess lower alcohols and carboxylic acid esters; (2) converting oligomer esters contained in the bottom liquid to carboxylic acid esters by depolymerizing the oligomer esters at a high temperature and high pressure in the presence of a lower alcohol and a catalyst; and (3) hydrogenating the carboxylic acid esters distilled off in the step (1) and the carboxylic acid esters obtained in the step (2) either respectively or collectively to convert to 1,6-hexanediol.

A reactive mesogen compound, a liquid crystal composition including the reactive mesogen compound, a method of manufacturing a display panel, and a display panel are disclosed. The reactive mesogen compound may be activated by light having a wavelength between about 300 nm and about 700 nm.

An active energy ray curable resin composition for a sheet-like optical article capable of providing a cured material having a dynamic elastic modulus at 25° C. of 950 MPa or less and a dynamic elastic modulus at 60° C. of 100 MPa or more and a sheet-like optical article prepared from the resin composition are disclosed. The sheet-like optical article (e.g., prism sheet) has good heat resistance and extremely small warpage.

Polymerizable compositions that include: (a) a cationically active functional group; (b) an initiation system capable of initiating cationic polymerization of the cationically active functional group; and (c) a filler composition that includes various radiopacifying fillers in an amount sufficient to render the polymerizable composition radiopaque. Components (a), (b), and (c) are selected such that the polymerizable composition polymerizes to form a polymerized composition having a Barcol hardness, measured using a GYZJ-935 meter, of at least 10 within 30 minutes following initiation of the cationically active functional group at a reaction temperature of 25° C.

The invention provides a method for preparing a hexamethylenediamine key intermediate 6-aminocapronitrile by a two-step method. The method comprises the following steps: step S1, in a first reactor, after caprolactam is subjected to a hydrolysis reaction in an aqueous solution, introducing first hot ammonia gas into the first reactor to obtain an aminocaproamide crude product, the temperature of the first hot ammonia gas being 150-250 DEG C; S2, performing catalytic dehydration on the aminocaproamide crude product and second hot ammonia gas in a second reactor to obtain aminocapronitrile, wherein the temperature of the second hot ammonia gas ranges from 200 DEG C to 300 DEG C. According to the invention, the polymerization of the hydrolysate is effectively controlled in the step S1 so thatpolymerization of the polymer on the surface of the catalyst when the aminocaproamide crude product participates in the catalytic dehydration reaction in the step S2 is effectively relieved, coking of the catalyst is avoided, the service life of the catalyst is prolonged, and then lasting high-conversion-rate and high-selectivity preparation of 6-aminocapronitrile from caprolactam is guaranteed.

The invention relates to a continuous preparation method for synthesizing isobornyl acetate by esterification of camphene and acetic acid. Using camphene and acetic acid as raw materials, using solid acid as a catalyst, and adding a certain amount of polymerization inhibitor and acetic anhydride, the esterification reaction is carried out under certain process conditions in a catalyst bed filled with suspension, and the target product acetic acid is obtained. Isobornyl. The invention has the advantages of mild reaction conditions, long service life of the catalyst, good product quality, high raw material conversion rate, continuous production and simple operation, and can be widely used in large-scale industrial production of isobornyl acetate.

The invention provides a brominated polymer flame retardant and a preparation method thereof and belongs to the field of chemical and constructing material flame retardants. The preparation method comprises the following steps: at 0 DEG C, dripping a certain ratio of diluted bromine into a styrene-butadiene copolymer solution; and reacting by adopting a specific temperature rising mechanism to finally prepare the target brominated polymer flame retardant. The brominated polymer flame retardant provided by the invention has good compatibility with a polystyrene material, a high oxygen index and a good flame retarding effect; the preparation method provided by the invention is simpler and bromine is directly used for carrying out bromine addition, so that introduction of other impurities and byproducts is effectively avoided; and the difficulty of post-treatment is reduced and the cost of a whole synthesizing process is reduced.

A method simply produces a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end without using a heavy metal catalyst. A method for producing a polyalkylene glycol derivative having an amino group at the end by reacting a compound represented by the general formula (V) with an alkylene oxide, then reacting a reaction product with an electrophile represented by the general formula (I), and deprotecting the obtained product without using a heavy metal:

R_A³O(R_A⁴O)_k-1R_A⁴O⁻M⁺  (V)

• • wherein R_A³ represents a linear; branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms; R_A⁴ represents an alkylene group having 2 to 8 carbon atoms; k represents an integer of 2 to 5; and M represents an alkali metal;