Preparation method of 6-H-phenanthridine compounds by one-pot process
A technology for 6-H-compounds, applied in organic chemistry, bulk chemical production, etc., can solve the problems of few reports on the synthesis of phenanthridine compounds, and achieve the effects of easy reaction, high yield and easy availability of raw materials
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[0023] The embodiments of the present invention will be further described below in conjunction with the accompanying drawings and specific examples, but the present invention is not limited to the following embodiments, and various changes may be made within the scope of knowledge of those skilled in the art.
[0024] A "one-pot method" for the preparation of 6- H -The method of phenanthridine compound, its reaction process is as follows:
[0025]
[0026] Among them, PG (ProtectedGroup) is a protecting group, including -Ms (methylsulfonyl), -Ts (p-toluenesulfonyl), -Ns (p-nitrobenzenesulfonyl) and -Ac (acetyl); substituent R 1 and R 2 Any of alkyl, alkoxy, acyl, nitro, cyano, and halogen.
[0027] The operation steps of synthetic representative compound 1:
[0028]
[0029] Will N -Protected arylamine, o-bromobromobenzyl compound, metal palladium catalyst, ligand and base are added in an organic solvent, reacted under heating and inert gas protection conditions, an...
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