15 results about "Synthetic ligands" patented technology

The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and / or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

The application discloses a single-center catalyst and a preparation method and application thereof. The catalyst system introduces a large steric hindrance aniline on a highly rigid 2-phenyl quinoline skeleton, thereby providing better protection for the active center of the catalytic system, enhancing the high-temperature resistance and activity of the catalytic olefin polymerization, and the polymerization activity at 150 DEG C can be more than 1*10 7 6 g / (mol.h). The synthetic route adopted in the application is simple and easy to operate, and a ligand with a high yield can be obtained through one-step reaction, that is, the yield of the ligand synthesized from 2-phenyl-8-amino quinoline raw material is more than 75%, which is favorable for improving the production efficiency and yield of the product.

The application discloses an organic complex of different metals LTG-RuCe and a preparation method and application thereof, and belongs to the technical field of catalysts. The preparation method of the organic complex of different metals LTG-RuCe comprises the following steps: synthesizing a ligand HL by using methyl formylbenzoate, 2-acetylpyridine, ethanol, potassium hydroxide and ammonia water; synthesizing a ligand [Ru(HL)2]·(PF6)2 by using trichlororuthenium, the ligand HL, methanol, potassium hydroxide and HPF6; and synthesizing the organic complex of different metals LTG-RuCe by using cerium nitrate hexahydrate, the ligand [Ru(HL)2]·(PF6)2 and N,N-dimethylformamide. The organic complex of different metals LTG-RuCe synthesized by the application has high CO2 catalytic activity, good repeatability and a structure which is not easy to collapse; and the method for preparing the organic complex of different metals provided by the application has high yield and strong operability.

The application discloses a kind of chiral 8-hydroxyquinoline skeleton nitrogen-oxygen ligand, preparation method and application, belong to quantum dot ligand field, the chiral 8-hydroxyquinoline skeleton nitrogen-oxygen ligand structure as shown in formula (I).The ligand has fluorescence and-chiral property, its stable conjugate structure is conducive to electron transport and photoelectric conduction, it has excellent universal performance when being applied to nano quantum dot surface ligand exchange, can replace the original ligand on quantum dot surface, and pass chiral to quantum dot-ligand system, so that quantum dot-ligand system has with the chiral raw material and chiral 8-hydroxyquinoline skeleton nitrogen-oxygen ligand of synthesis ligand different circular dichroism signal.At the same time, the preparation method of the ligand is simple, reaction condition is mild, reaction efficiency is high, can realize large-scale preparation production.Formula (I).

The present application relates to the technical field of catalyst, in particular to a synthesis method of active site adjustable bimetallic catalyst.The synthesis method of active site adjustable bimetallic catalyst comprises the following steps: synthesizing ligand;preparing bimetallic complex;limiting domain pyrolysis carbonization.The present application first takes p-tert-butylphenol, polyformaldehyde and bis(2-pyridylmethyl)amine as raw materials, reacts in a mixed solvent to synthesize ligand Hbpbp, then sequentially reacts with metal salt in methanol by a stepwise coordination method to construct homonuclear or heteronuclear bimetallic complex, finally uniformly mixes the complex with carbon black and dicyandiamide, and performs programmed temperature carbonization under inert atmosphere to prepare bimetallic catalyst with atomic level dispersion structure, realizes accurate anchoring and stable loading of bimetallic sites on the carbon carrier, and not only has high activity and stability in electrocatalytic carbon dioxide reduction reaction, but also can efficiently activate peroxymonosulfate for pollutant degradation.

The invention relates to the technical field of modified foamed nickel catalysts for catalyzing hydrosilylation reaction, and discloses an alloy modified foamed nickel catalyst, a preparation method and application, and the preparation method specifically comprises the following steps: synthesizing a ligand type silane coupling agent; based on a silicon hydroxyl-hydroxyl condensation reaction mechanism, a ligand type silane coupling agent is grafted to the surface of foamed nickel, and surface ligand modified foamed nickel is prepared; a ligand type silane coupling agent grafted on the surface of foamed nickel and an imidazole monomer are used as a composite ligand, and the composite ligand, nickel-platinum alloy and dissolved nickel ions are subjected to MOF material assembly with the nickel-platinum alloy as a core on the surface of the foamed nickel through coordination, so that the alloy modified foamed nickel catalyst is prepared. The catalyst product shows very excellent catalytic activity in a hydrosilylation reaction.

The application relates to the field of semiconductors, and particularly relates to a quasi-solid-phase-based fuel cell platinum-based catalyst and a preparation method thereof. A preparation method of a quasi-solid-phase-based fuel cell platinum-based catalyst comprises the following steps: mixing an organic synthetic ligand, a catalyst carrier and a platinum-based organic ligand in a low-boiling-point organic solvent; removing the low-boiling-point organic solvent to obtain a pre-annealed precursor; and high-temperature annealing the pre-annealed precursor under an argon gas atmosphere or an argon-hydrogen gas atmosphere at 230-290 DEG C for 1-2 hours to obtain the quasi-solid-phase-based fuel cell platinum-based catalyst. The quasi-solid-phase method can prevent the agglomeration of nanoparticles under high-temperature conditions, realize accurate micro-control of the size of platinum-based nanoparticles, and the synthesized platinum-based nanoparticle material has small particle size, good performance and high stability.

The invention discloses a chiral 8-hydroxyquinoline skeleton nitrogen-oxygen ligand, a preparation method and application, and belongs to the field of quantum dot ligands, and the structure of the chiral 8-hydroxyquinoline skeleton nitrogen-oxygen ligand is shown as a formula (I). The ligand has fluorescence and-chiral properties, a stable conjugated structure of the ligand is beneficial to electron transmission and photoelectric conduction, the ligand has excellent universality when being applied to ligand exchange on the surface of a nano quantum dot, an original ligand on the surface of the quantum dot can be replaced, chirality is transmitted to a quantum dot-ligand system, and the quantum dot-ligand system can be used for preparing the quantum dot. The quantum dot-ligand system has a circular dichroism signal which is different from a chiral raw material for synthesizing the ligand and a nitrogen-oxygen ligand of a chiral 8-hydroxyquinoline skeleton. Meanwhile, the preparation method of the ligand is simple, the reaction condition is mild, the reaction efficiency is high, and large-scale preparation and production can be realized. Formula (I)

The present disclosure relates to ligand-payload conjugates, and compositions and use thereof for treating diseases, disorders, or conditions, such as cancers, autoimmune diseases, or infectious diseases. The present disclosure also provides methods of synthesizing ligand-payload conjugates, and related intermediates.

The present invention relates to improved variants of the split HaloTag system. HaloTag is a self-labelled protein tag, derived from bacterial proteins and capable of covalently binding to synthetic ligands including reactive chloroalkanes. The HaloTag can be split into a cpHalodelta protein and a complementary peptide, which are active only when closely approached. The present invention relates to improved sequences of this isolated HaloTag system, which are more stable than molecules in the art and exhibit faster kinetics.

The invention discloses a single-site catalyst as well as a preparation method and application thereof. According to the catalyst system, aniline with large steric hindrance is introduced to a framework of 2-phenylquinoline with high rigidity, so that better protection is provided for an active center of the catalyst system, the high temperature resistance and activity of catalyzing olefin polymerization are enhanced, and the polymerization activity at 150 DEG C can exceed 1 * 10 < 7 > g / (mol.h). The synthesis route adopted in the method is simple and easy to implement, the ligand with high yield can be obtained through one-step reaction, that is, the yield of the ligand synthesized from the 2-phenyl-8-aminoquinoline raw material exceeds 75%, and the production efficiency and the yield of the product can be improved.

This invention relates to the field of modified nickel foam catalysts for catalyzing hydrosilylation reactions, and discloses alloy-modified nickel foam catalysts, preparation methods, and applications. Specifically, it involves: synthesizing ligand-type silane coupling agents; grafting the ligand-type silane coupling agent onto the surface of nickel foam based on the silanol-hydroxyl condensation reaction mechanism to obtain surface-ligand-modified nickel foam; using the ligand-type silane coupling agent grafted onto the surface of nickel foam and imidazole monomers as composite ligands, and assembling a nickel-platinum alloy and dissolved nickel ions on the surface of nickel foam through coordination to form a MOF material with the nickel-platinum alloy as the core, thereby obtaining an alloy-modified nickel foam catalyst. This catalyst product exhibits excellent catalytic activity in hydrosilylation reactions.

The invention relates to the technical field of catalysts, in particular to a synthesis method of an active site adjustable bimetallic catalyst. The invention discloses a synthesis method of an active site adjustable bimetallic catalyst. The synthesis method comprises the following steps: synthesizing a ligand; preparing a bimetallic complex; and carrying out confined domain pyrolysis and carbonization. The preparation method comprises the following steps: reacting p-tert-butylphenol, paraformaldehyde and di (2-pyridyl methyl) amine serving as raw materials in a mixed solvent to synthesize a ligand Hbpbp, sequentially reacting the ligand Hbpbp with metal salt in methanol through a step-by-step coordination method to construct a homonuclear or heteronuclear bimetallic complex, and finally uniformly mixing the complex with carbon black and dicyandiamide to obtain the carbon black / dicyandiamide complex. The bimetallic catalyst with an atomic-scale dispersion structure is prepared by carrying out temperature programmed carbonization in an inert atmosphere, so that precise anchoring and stable loading of bimetallic sites on a carbon carrier are realized, and the bimetallic catalyst not only has high activity and stability in an electro-catalysis carbon dioxide reduction reaction, but also can efficiently activate peroxymonosulfate for pollutant degradation.

A pyrazole-cobalt-based metal-organic framework material with dynamic pore size is used to capture sulfur hexafluoride, belonging to the technical field of preparation of crystalline porous materials. Co-DPB is synthesized by organic ligand (H2DPB) [H2DPB = 1,3-di(1-H-pyrazolyl)benzene] and cobalt acetate tetrahydrate under solvent thermal conditions. The vibration of the ligand benzene ring gives the MOF a dynamic pore size, which is beneficial to enhance the force on the sulfur hexafluoride molecule. Based on the strong force of Co-DPB on sulfur hexafluoride, it exhibits excellent sulfur hexafluoride / nitrogen separation ability. In addition, Co-DPB also has high thermal stability and moisture resistance, and has potential application prospects for the capture of sulfur hexafluoride in real industrial tail gas.

The invention discloses a gas sensitive material, a preparation method thereof and a mould detection sensor, and belongs to the technical field of gas sensing. The gas sensitive material comprises a metal oxide matrix and an AuPt bimetallic alloy nanocluster loaded on the surface of the metal oxide matrix, wherein the atomic ratio of Pt to Au in the cluster is (0.1: 1)-(0.5: 1). The preparation method comprises the following steps: synthesizing the ligand-protected AuPt bimetallic nanocluster, anchoring the ligand-protected AuPt bimetallic nanocluster on the surface of the metal oxide matrix by a post-loading method, and finally roasting at low temperature to remove the ligand. According to the material, the synergistic effect of the bimetallic nanoclusters is utilized, and the response rate, the sensitivity and the selectivity to the mould marker 1-octylene-3-alcohol are remarkably improved. The detection limit of a sensor constructed based on the material to 1-octylene-3-alcohol at 150 DEG C reaches 12 ppb, various moulds such as aspergillus flavus and aspergillus niger can be effectively recognized, the detection limit to the aspergillus flavus is as low as 10 CFU / mL, and the material has application prospects in the field of food safety monitoring.