Asymmetry oxamide fiber-bridged three-kernel copper complex as well as preparation method and application thereof

A technology of oxamide bridge and copper complex is applied in copper organic compounds, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of high yield, wide application range and high antitumor activity
CN103724364AInactive Publication Date: 2014-04-16QINGDAO MUNICIPAL HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QINGDAO MUNICIPAL HOSPITAL
Publication Date
2014-04-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an asymmetry oxamide fiber-bridged three-kernel copper complex as well as a preparation method and application thereof. The complex is generated from Cu<2+> and asymmetry oxamide ligand H3bdeox, perchlorate and 1,10-phenanthroline; the coordination polymer is of a trimetal central structure, and the molecular structure formula of the coordination polymer is [Cu3(bdeox)(phen)3(H2O)](ClO4)3?H2O, wherein Cu is bivalent copper ion, and H3bdeox is N-(2-carboxyl benzene)-N'-[(2-aminoethyl)ethyl] oxamide. The asymmetry oxamide fiber-bridged three-kernel copper complex disclosed by the invention is low in cost, the raw materials for synthesis is readily available, the product is separated out in a crystal mode, is large in purity and high in yield, and moreover, the coordination polymer is stable in a natural state, and is good in water solubility and grease solubility; in addition, the coordination polymer has an excellent inhibition function on various cancer cells of liver cancer, lymphatic leukemia and the like, and is wide in action spectrum and wide in application range.
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Description

technical field

[0001] The invention belongs to the technical field of complexes, and in particular relates to an unsymmetrical oxamide-bridged trinuclear copper complex and its preparation method and application. Background technique

[0002] Copper is an important trace element, which plays an important role in the process of cell formation, participates in the activities of various enzymes and important life hormones in the human body, and is closely related to bone development and normal metabolism of the central nervous system. In recent years, copper complexes have aroused great interest among scholars at home and abroad because of their nuclease activity. Copper complexes containing aromatic ring structures can not only inhibit the activity of DNA and RNA polynucleases, but also in the presence of oxidants such as hydrogen peroxide and oxygen. DNA fragmentation can also be induced under certain conditions, and even some complexes can induce DNA fragmentation under the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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