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Cu-Eu exotic-metal-substituted arsenotungstate as well as preparation method and application thereof

A technology of arsenic tungstate and heterometal, applied in chemical instruments and methods, tungsten compounds, pharmaceutical formulations, etc., to achieve the effect of improving stability and improving reactivity

Inactive Publication Date: 2015-05-13
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no research report on copper-europium heterometallic substituted arsenic tungstate and its pharmaceutical activity

Method used

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  • Cu-Eu exotic-metal-substituted arsenotungstate as well as preparation method and application thereof
  • Cu-Eu exotic-metal-substituted arsenotungstate as well as preparation method and application thereof
  • Cu-Eu exotic-metal-substituted arsenotungstate as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of copper-europium heterometallic substituted arsenic tungstate, its chemical formula is: Na 2 K 3.5 Eu 0.5 [Eu(H 2 O) 7 ][As 2 W 19 Cu 2 o 67 (H 2 O) 3 ]·22H 2 O.

[0036] The above-mentioned copper-europium heterometallic substituted arsenic tungstate is synthesized by a traditional aqueous solution method, and its preparation method specifically includes the following steps:

[0037] 1) Preparation of arsenotungstate precursor K 14 [As 2 W 19 o 67 (H 2 O)]; details can be found in the literature (U. Kortz, M. G. Savelieff, B. S. Bassil, M. H. Dickman, Angew. Chem. Int. Ed. 2001 , 40 , 3384—3386) for preparation;

[0038] 2) In a 25 mL beaker, 0.263 g (0.050 mmol) of K 14 [As 2 W 19 o 67 (H 2 O)], 0.075 g (0.440 mmol) CuCl 2 2H 2 O, 0.056 g (0.217 mmol) EuCl 3 and 0.060 g (1.027 mmol) of NaCl were dissolved in 15 mL (833 mmol) of distilled water, stirred at room temperature for 2 h to form a homogeneous mixed phase, then placed in a...

Embodiment 2

[0040] A kind of copper-europium heterometallic substituted arsenic tungstate, its chemical formula is: Na 2 K 3.5 Eu 0.5 [Eu(H 2 O) 7 ][As 2 W 19 Cu 2 o 67 (H 2 O) 3 ]·22H 2 O.

[0041] The above-mentioned copper-europium heterometallic substituted arsenic tungstate is synthesized by a traditional aqueous solution method, and its preparation method specifically includes the following steps:

[0042] 1) Preparation of arsenotungstate precursor K 14 [As 2 W 19 o 67 (H 2 O)]; details can be found in the literature (U. Kortz, M. G. Savelieff, B. S. Bassil, M. H. Dickman, Angew. Chem. Int. Ed. 2001 , 40 , 3384—3386) for preparation;

[0043] 2) In a 25 mL beaker, 0.263 g (0.050 mmol) of K 14 [As 2 W 19 o 67 (H 2 O)], 0.025 g (0.147 mmol) CuCl 2 2H 2 O, 0.043 g (0.166 mmol) EuCl 3 and 0.060 g (1.027 mmol) of NaCl were dissolved in 15 mL (833 mmol) of distilled water, stirred at room temperature for 2 h to form a homogeneous mixed phase, then placed in a...

Embodiment 3

[0045] A kind of copper-europium heterometallic substituted arsenic tungstate, its chemical formula is: Na 2 K 3.5 Eu 0.5 [Eu(H 2 O) 7 ][As 2 W 19 Cu 2 o 67 (H 2 O) 3 ]·22H 2 O.

[0046] The above-mentioned copper-europium heterometallic substituted arsenic tungstate is synthesized by a traditional aqueous solution method, and its preparation method specifically includes the following steps:

[0047] 1) Preparation of arsenotungstate precursor K 14 [As 2 W 19 o 67 (H 2 O)]; details can be found in the literature (U. Kortz, M. G. Savelieff, B. S. Bassil, M. H. Dickman, Angew. Chem. Int. Ed. 2001 , 40 , 3384—3386) for preparation;

[0048] 2) In a 25 mL beaker, 0.263 g (0.050 mmol) of K 14 [As 2 W 19 o 67 (H 2 O)], 0.070 g (0.411 mmol) CuCl 2 2H 2 O, 0.048 g (0.186 mmol) EuCl 3 and 0.120 g (2.054 mmol) NaCl were dissolved in 15 mL (833 mmol) distilled water to form a homogeneous mixed phase, then placed in a water bath at 80 °C and heated for 1.5 h, ...

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Abstract

The invention relates to Cu-Eu exotic-metal-substituted arsenotungstate which has a chemical formula as follows: Na2K3.5Eu0.5[Eu(H2O)7][As2W19Cu2O67(H2O)3].22H2O. A compound is prepared by reacting EuCl3, CuCl2.2H2O, NaCl and an arsenotungstate precursor-K14[As2W19O67(H2O)] in an aqueous solution. A preparation method is simple, easy to operate and relatively low in cost. Tests discover that the compound has a remarkable inhibition effect on the growth of human hepatocarcinoma cells HepG2 and human colonic cancer cells HCT-116 and can be used for preparing drugs for resisting cancers, especially liver cancers and colonic cancers, and research results provide an experimental basis for application of the compound to an aspect of drug activity.

Description

technical field [0001] The invention belongs to the technical field of preparation of polyoxometalate chemical materials, and specifically relates to a copper-europium heterometallic substituted arsenic tungstate, a preparation method and its application in the preparation of anticancer drugs. The compound uses copper ions, europium It is prepared by reacting ions with the precursor of arsenotungstate under the condition of normal temperature aqueous solution. Background technique [0002] Polyoxometalates are a class of oxygen clusters formed by connecting high-priced early transition metal ions (mainly including molybdenum, tungsten, vanadium, niobium, etc.) through oxygen atoms. Because of their oxygen-rich surfaces, controllable structure, size, compositional and structural diversity, and unique redox activities, they have attracted great attention in the fields of catalysis, fluorescence, magnetism, and pharmaceuticals. For example, in 2003, Mizuno et al. reported that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G41/00
CPCA61K33/34C01G41/006C01P2004/61
Inventor 李明雪陈利娟罗婕赵俊伟刘建彩张芳
Owner HENAN UNIVERSITY
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