74 results about "Cinnamates" patented technology

The invention relates to the field of biological engineering and technology, in particular to an enzyme for synthesizing glabridin, a biological synthesis method of glabridin and a bacterial strain. The invention discloses a series of glabridin synthesizing enzymes (phenylalanine ammonialyase, cinnamic acid-4-hydrogenase, tyrosine ammonialyase, p-coumaric acid coenzyme A ligase, chalcone synthase, chalcone reductase, chalcone isomerase, isoflavone synthase, 2-hydroxyisoflavone dehydratase, 4 '-oxymethyltransferase, 4'-hydroxymethyltransferase and 4 '-hydroxymethyltransferase) derived from glycyrrhiza glabra for the first time. ) can be used in the preparation of a compound (e.g., isoflavone 2 '-hydrogenase, isoflavone reductase, Vissisoketoreductase, isoprenyltransferase, pterocarpin reductase, oxidative cyclase, demethylase, cytochrome P450 reductase, and the like). The de novo synthesis of the glabridin in a microbial cell factory is realized for the first time, and the application prospect of the glabridin biological manufacturing industry is greatly promoted.

The invention provides a preparation method of Keemun camellia seed fermented oil, and belongs to the technical field of vegetable oil production. The preparation method comprises the following steps: S1, preparing recombinant saccharomycetes; s2, jointly fermenting the antarctic torulopsis, the recombinant saccharomycetes and the Keemun camellia seed oil; s3, separating an oil phase from a water phase, and taking the oil phase; and S4, dehydrating the oil phase to obtain the Keemun camellia seed fermented oil. Preferably, according to the preparation method of the recombinant saccharomycetes in the step S1, phenylalanine deaminase, cinnamate hydroxylase, 4-coumaric acid CoA ligase, chalcone synthetase, chalcone reductase and peroxidase are expressed in saccharomyces cerevisiae. According to the Keemun camellia seed fermented oil prepared by the method disclosed by the invention, the characteristic components of the Keemun camellia seed oil can be remarkably improved, the antioxidant capacity of the Keemun camellia seed oil is enhanced while the skin feeling of the Keemun camellia seed oil is improved, and the application value of the Keemun camellia seed oil in cosmetics is improved.

The present invention belongs to the field of fermentation engineering, and specifically relates to a yeast and its application in linseed oil fermentation and a linseed hydroponic oil product. The genetically recombinant yeast expresses phenylalanine deaminase, tyrosine deaminase, cinnamic acid hydroxylase, 4-coumaric acid CoA ligase, chalcone synthase, chalcone isomerase, flavonoid 3-hydroxylase and stilbene synthase. The linseed hydroponic oil obtained by fermenting genetically recombinant yeast and linseed oil in the present invention has enhanced stability and is not prone to mutation; and the linseed hydroponic oil has a higher total flavonoid content, better antioxidant activity and tyrosinase inhibition activity than linseed oil.

The invention discloses an escherichia coli engineering strain with high benzyl acetate yield and application thereof. The escherichia coli strain efficiently expresses a brand new biosynthetic pathway related gene of benzyl acetate; comprising a phenylalanine lyase gene, a cinnamic acid coenzyme A ligase gene, a 3-hydroxyacyl coenzyme A dehydrogenase gene, a 3-oxoacyl coenzyme A ketohydrolase gene, an enoyl coenzyme A hydratase gene, a carboxylic acid reductase gene, a phosphoric acid pantetheinyl transferase gene and an acyltransferase gene. The obtained escherichia coli engineering strain can utilize a sustainable and cheap raw material glucose as a carbon source to realize efficient synthesis of benzyl acetate. The yield of benzyl acetate synthesized by the escherichia coli benzyl acetate engineering bacteria is the highest yield of benzyl acetate synthesized by a microbial fermentation method reported at home and abroad from beginning. The benzyl acetate produced by the engineering strain has the advantages of reliable quality, economic product, green production and the like, and has important economic value and social benefit.

The application relates to the technical field of injection molding demolding master batches, in particular to a polyester transparent injection molding demolding master batch and a preparation method and application thereof. According to mass proportions, 85% to 97% of a carrier and 3% to 15% of a lubricant are included; the lubricant includes zinc bungarotoxin, zinc cinnamate and octadecyl octadecanoate with a mass ratio of (2 to 6):(2 to 6):(1 to 4). The lubricant with the specific component ratio improves the fluidity and demolding property of the polyester product and reduces the haze.

The invention relates to the technical field of biological medicine, in particular to application of esterified derivatives of methyl p-hydroxycinnamate in preparation of antitumor drugs. Experiments show that the derivative has an obvious inhibition effect on the cell viability of tumor cells such as gastric cancer, nasopharynx cancer and breast cancer, particularly has obvious proliferation, migration and invasion inhibition ability on the gastric cancer cells, can induce apoptosis of the gastric cancer cells, has relatively low toxic and side effects, and provides a new medicine for treating the gastric cancer.

The present invention relates to a composition comprising: 1) at least one inorganic UV filter selected from titanium dioxide; 2) at least one α-cyanodiphenylacrylate derivative of the given formula; and 3) at least one 4-hydroxybenzylidenemalonate or 4-hydroxycinnamate derivative of the given formula. The present invention also relates to a cosmetic method for treating skin against UV radiation using said composition.

The invention discloses a multi-scene deodorizing detergent composition and a preparation method thereof, and relates to the technical field of daily chemical industry. The multi-scene deodorizing detergent composition provided by the invention is prepared from the following core components: alkyl glycoside, sodium lauroamphoacetate, tea saponin, hydroxypropyl-beta-cyclodextrin, chitosan, compound enzyme, sodium cinnamate, dragon fruit extract, humulus lupulus extract and the like. Through the synergistic effect of all the components, the composition realizes integration of multiple effects: the irritation is remarkably reduced and the skin barrier is maintained while efficient decontamination is realized; an adsorption-degradation system formed by hydroxypropyl-beta-cyclodextrin, chitosan and compound enzyme can radically remove peculiar smell and efficiently degrade pesticide residues; the chitosan and the pitaya extract synergistically chelate heavy metal ions; and components such as sodium cinnamate have natural whitening and broad-spectrum preservative functions. The technical limitation that a traditional product is single in function is broken through, and a comprehensive and safe washing solution with a positive skin care effect is provided.

An objective of the present invention is to provide a photosensitive organic insulating composition having sufficient absorption, even of i-line radiation, as a photosensitive organic insulating composition that has little influence on device reliability and that is capable of forming a gate insulating film for transistors. An objective of the present invention is also to provide a gate insulating film and a transistor. A photosensitive organic insulating composition according to one embodiment of the present invention contains a chalcone compound and polyvinyl cinnamate.

The present invention discloses a composition and method for treating arthritis. The composition comprises a binary blend of molecules including citral, methyl cinnamate, and epicurzerenone. The binary blend exhibits synergistic efficacy in modulating inflammatory cytokines. The citral, epicurzerenone, and methyl cinnamate, are derived from essential oils of Cymbopogon citratus, Hedychium spicatum, and Zanthoxylum armatum, respectively. Both individual and binary blend exhibits downregulation of pro-inflammatory cytokines IL-2, IL-6, and TNF-α, and upregulation of anti-inflammatory cytokine IL-10

The invention discloses a method for fixed-point modulation of acidity of a molecular sieve. The method comprises the following steps: (1) dissolving a proper amount of cinnamate in benzene, uniformly stirring, and fully dissolving; (2) impregnating a molecular sieve with the solution obtained in the step (1), and filtering the molecular sieve after impregnation; wherein the pore diameter of the molecular sieve is 0.4 nm to 0.9 nm; (3) purging the molecular sieve filtered out in the step (2) with hot nitrogen, and naturally cooling to room temperature after purging; and (4) cleaning the molecular sieve obtained in the step (3) with deionized water to obtain the acid center modulated molecular sieve. According to the invention, only the acid center at the cross position of the molecular sieve pore channel is modified, the acid center at the straight-through pore channel is not influenced, and the smoothness of the pore channel is not influenced.

The present invention provides matrices for use in mass spectrometry, particularly matrix-assisted laser desorption / ionization mass spectrometry techniques. Methods of use, including for imaging mass spectrometry, of the presently disclosed matrices are also provided.

A cosmetic skin care composition having a peptide derivative, a fatty acid having from about 8 to about 22 carbon atoms, and a dermatologically acceptable carrier. The peptide derivative has a formula: Rc-R1-Gly-Pro-Gln-Gly-R2, where Rc is chosen from hydroxycinnamic acid, its derivative, and mixtures thereof, where R1 and R2 are respectively from about 0 to about 8 amino acids, and wherein a total of R1 and R2 is 8 or less amino acids; The composition provides improved penetration of such peptide derivatives to skin.

This invention generally relates to the use of hydroxycinnamic acid or its derivatives, such as alginate, in cosmetic or therapeutic settings. The invention further relates to compositions comprising hydroxycinnamic acid or its derivatives.

The present invention provides a repellent composition for mites which is excellent in mite-repelling effect against indoor mites even after a long period of time and is also excellent in safety to humans and animals. The present invention relates to a repellent composition for mites, which contains: (a) 1,8-cineol and / or 1,4-cineol and (b) a perfume ingredient, wherein the perfume ingredient contains one or two or more kinds of perfume compounds having a logP value of 2.0 to 5.5. The mixing ratio (a) / (b) of the (a) ingredient to the perfume compounds contained in the (b) ingredient is set to 5 to 100 on a mass basis. The perfume compounds contained in the (b) ingredient are at least one selected from the group consisting of ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclo decenyl propionate, benzyl salicylate, limonene, and amyl salicylate.

The present application provides use of compounds represented by formula (I) and formula (II) in the preparation of drugs for improving male reproductive ability. In the present application, different oligoasthenospermia models are constructed, and the improvement effects of the compounds represented by formula (I) and formula (II) on male reproductive ability impairment are verified by means of sperm count analysis, sperm motility analysis, mRNA expression level analysis of inflammatory and antioxidant genes, testicular histopathological damage analysis, etc. The experimental results show that the compounds represented by formula (I) and formula (II) increase the sperm count in mice with oligoasthenospermia, improve the sperm motility of the mice with oligoasthenospermia, ameliorate testicular histopathological damage in the mice, suppress the expression of inflammatory factors, and increase the expression of antioxidant genes, demonstrating great potential in the treatment of oligoasthenospermia.

The invention discloses a sun-proof laminated glass for vehicle windows and a preparation method thereof, and relates to the technical field of glass. The invention uses 4-methoxycinnamic acid, 2-hydroxy-5-(2-hydroxyethyl) benzaldehyde, and a compound synthesized by p-aminobenzoic acid to be intercalated in magnesium-aluminum hydrotalcite, introduces a cinnamate structure and a Schiff base structure between the layers, combines the ultraviolet shielding effect of the hydrotalcite, effectively absorbs ultraviolet light, and preliminarily realizes the ultraviolet blocking performance of the laminated glass; then, the hydrotalcite is further modified by KH151, and then polymerized with acrylic acid, acrylamide, and chitosan to form a self-adhesive hydrogel, bond the glass, and form a sandwich structure, and then, titanium dioxide, silicon dioxide, and antimony tin oxide film layers are sequentially sputtered and deposited on the surface of the laminated glass to form a three-layer composite film layer, construct a sunlight filtering system, reduce ultraviolet and infrared light transmission, and greatly reflect heat rays to form a heat insulation structure.

A liquid nicotine formulation for an aerosol-generating system is provided, the nicotine formulation including: one or more water-miscible polyhydric alcohols, the nicotine formulation having a water-miscible polyhydric alcohol content of greater than or equal to about 5 percent by weight; and one or more low molar mass metal salts, the one or more low molar mass metal salts being selected from the group consisting of metal cinnamates, metal cycloheptanecarboxylates, metal levulinates, metal propanoates, metal stearates, and metal undecanoates. An aerosol-generating article and an aerosol-generating system are also provided.

This invention belongs to the field of polyether polyol synthesis technology, specifically relating to bio-based high-strength polyether ester polyols and their preparation methods. The bio-based high-strength polyether ester polyol is obtained from the following raw materials: small molecule polyol, catalyst, bio-based epoxide, and bio-based phenyl ester compound; the bio-based epoxide is one or more of limonene epoxide, α-pinene oxide, and caryophyllene oxide; the bio-based phenyl ester compound is one or two of benzyl benzoate and benzyl cinnamate. The raw materials used in this invention can be obtained through natural plant extraction, achieving full bio-based polyether ester polyol production, thus fundamentally reducing dependence on fossil resources. By introducing a large number of cyclic and benzene ring structures into the polyol molecule, the resulting product is applied in the field of rigid polyurethane foam, increasing the content of rigid groups in the molecular chain structure, and significantly improving the strength of rigid polyurethane foam compared to traditional polyether polyols.

The present invention provides a modified C9 hydrogenated petroleum resin, a preparation method and application thereof. The preparation method of the modified C9 hydrogenated petroleum resin comprises: in the presence of an initiator, a polar grafting activator and a solvent, a C9 hydrogenated petroleum resin and an acidulant are subjected to a grafting reaction to obtain a grafted product system, wherein the acidulant is an unsaturated acid anhydride and / or an unsaturated acid, and the polar grafting activator is selected from a cinnamate activator and a styrene activator; and the grafted product system is extracted with a strong polar solvent to obtain an extracted product, wherein the solubility parameter of the strong polar solvent is greater than 3.0 (cal / cm 3 ) 1 / 2 ; Removing the solvent from the extraction product to obtain a modified C9 hydrogenated petroleum resin. The modified C9 hydrogenated petroleum resin prepared by the present invention is used to improve the compatibility of C9 hydrogenated petroleum resin with polar polymers such as EVA, PU, ​​etc., and can be used in the field of hot melt pressure sensitive adhesives to improve the compatibility of pressure sensitive adhesives with polar materials, thereby increasing the adhesive force.

The present invention relates to some crystal forms for a cinnamic compound, BMX, which is an inhibitor of histone deacetylase (HDAC), useful as an agent for the prevention or treatment of diseases associated with HDAC, including for treating tumor or cell proliferative diseases, diabetes mellitus, or neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA) and human spinal muscular atrophy (SMA). Also provided are a method for preparing the crystal forms and pharmaceutical compositions comprising the crystal forms.

The application discloses a kind of strawberry wine and its brewing method, adopt first Angelus yeast SY after Angelus yeast RW fermentation after the strawberry wine aroma compound content of aging is ester > alcohol > acid > other > terpene class.SY+RW fermentation of strawberry wine aroma compound content is ester > alcohol > other > acid > terpene class, it is rich in the complexity of wine aroma, give fruit wine more elegant and unique aroma;Wherein, in the fermentation of Angelus yeast SY, the highest OAV value of isoamyl acetate is given, and the main fermentation stage of wine body presents the rich banana aroma;In the fermentation stage of Angelus yeast RW, the content of ester is more, wherein the highest OAV value of ethyl decanoate and isoamyl acetate is given, and the rich pineapple, banana aroma of post-fermentation stage of wine body is given;With the progress of fermentation, the highest OAV value of ethyl cinnamate and phenylethanol is reached, and the rose flower fragrance and sweet amber paste fragrance of strawberry wine aging stage are given, and accompanied by the original aroma of strawberry fruit.

The application belongs to the field of natural product chemistry and medicinal chemistry, and discloses 10,11-dehydrovariecolin cinnamic acid derivatives, a preparation method and purposes thereof. The preparation method takes 10,11-dehydrovariecolin from a fungus as a starting material, and the target derivative is prepared by esterification reaction of the 5-position hydroxyl group of the starting material with cinnamic acid. The series of compounds show good bacteriostatic activity and antitumor activity, and can be used for preparing antitumor drugs or antibacterial drugs.

The invention discloses an HZSM-5 molecular sieve catalyst and a preparation method thereof. The catalyst comprises, by weight, 60%-85% of an HZSM-5 molecular sieve, 0.1%-6% of sodium oxide and / or potassium oxide and 13%-35% of aluminum oxide. The molar ratio of silicon to aluminum of the HZSM-5 molecular sieve is 40 to 150, and the indication constant k is 100 to 550. The preparation method of the catalyst comprises the following steps: firstly, dissolving cinnamate in benzene to prepare a solution, and enabling the solution to fully fill molecular sieve pores; blowing with hot nitrogen, and carrying out addition reaction on C = C of the cinnamate and benzene to generate a macromolecular salt product, so as to achieve the purpose of modifying an acid center at a pore crossing part; and preparing the catalyst according to a conventional method. The catalyst provided by the invention has proper activity, relatively high p-diethylbenzene selectivity and longer one-way operation period.

The present invention discloses a hyperbranched oil-soluble polyester heavy oil viscosity reducer and a preparation method thereof, belonging to the field of oilfield production additives. The invention first generates a hyperbranched polyester through an esterification reaction between trimethylolpropane, glycerol, and succinic anhydride. This polyester is then reacted with methyl erucate and methyl cinnamate through an ester exchange reaction to prepare a hyperbranched oil-soluble heavy oil viscosity reducer. Experimental results demonstrate that the heavy oil viscosity reducer exhibits significant viscosity reduction capabilities for heavy oil, achieving excellent viscosity reduction effects with a relatively low dosage and low raw material costs. Furthermore, the preparation method is simple, safe, environmentally friendly, and reliable.

Sunscreen-effective active ingredient combinations made up of (a) one or more cinnamic acid derivatives of formula (1a) and (1b) in which the groups X, Y and R can be chosen independently from the group hydrogen, and branched or unbranched C1-C 18 Alkyl, and (b) 4-Hydroxyacetophenone.

The application provides a fluorescent probe based on a cinnamic acid derivative as well as a synthesis method and application thereof, and relates to the technical field of synthesis of specific probes. The fluorescent probe is prepared by introducing benzyl bromide into the hydroxyl group of a modified structure compound FHA using p-hydroxycinnamic acid as raw material, and a novel bifunctional fluorescent probe capable of specifically detecting Al 3＋ and N2H4 is developed. The application overcomes the defects of the prior art, the probe can specifically detect Al 3+ and N2H4, and has the characteristics of low detection limit, short response time, wide pH application range and the like; the probe has the characteristics of good biocompatibility, small toxicity, good optical properties and the like, and can be applied to cell imaging experiments.

This invention relates to the field of biotechnology, and discloses an engineered *Yarrowia lipolytica* strain that produces p-coumaric acid using glucose as a substrate, its construction method, and its applications. Construction method: A tyrosine ammonia-lyase gene is integrated using a CRISPR / Cas9 localization and integration method. TAL In *Yarrowia lipophila* strains, the DAHP synthase gene was enhanced. ARO4 , DHS1 and AROG Overexpression of tyrosine synthase TYR Genes and histidine phosphotransferases HIS5 The protease gene was further integrated to synthesize exogenous phenylalanine deamination and hydroxylation pathway genes for p-coumaric acid, including phenylalanine ammonia-lyase gene, cinnamate hydroxylase gene, and P450 reductase gene. The p-coumaric acid produced by the engineered *Yarrowia lipolytica* strain of this invention can reach a maximum yield of 1.7 g / L in shake flasks, and a yield of 30 g / L in a 5 L fed-batch fermentation tank, demonstrating significant industrial application value.

The invention relates to the technical field of component design, in particular to a benzene ring acid group substitution type screening method based on isoamyl cinnamate and application of the benzene ring acid group substitution type screening method based on isoamyl cinnamate. The screening method comprises the steps that a virtual substituent library is established, acid group substituents are introduced to an isoamyl cinnamate benzene ring, and a plurality of substitution combinations are generated; predicting a minimum value pKai of an acid dissociation constant and a polar atom ratio PAR for each structure, and screening less than or equal to 50 candidate structures according to the minimum value pKai and the polar atom ratio PAR; measuring the fluorescence polarization anisotropy r of each candidate structure, and screening the first 50% of samples according to the sequence of r values from small to large; sequentially measuring the quantum dot fluorescence intensity retention rate Fret and the coating UVB retention rate RAUVB of the screened samples; and outputting the acid group substitution type corresponding to the maximum value according to the product sequence of the two. The self anti-ultraviolet attenuation capability and the photosensitive component protection effect are reflected, and the optimal structure is ensured to have self stability and synergistic protection performance in a real compound system.

This disclosure relates to pharmaceutical compositions useful for inhibiting the progression of a neurodegenerative disorder or glycine encephalopathy. The pharmaceutical compositions may include cinnamic acid. The pharmaceutical compositions and formulations may be orally administered to the patient.