The invention discloses a tera-hertz silica-based quadrupler and a frequency multiplier, belonging to the field of RFIC (Radio Frequency Integrated Circuit). The quadrupler comprises transistors (M1 and M2) and transmission lines (L1, L2 and L-1), wherein the drain ends of the transistors (M1 and M2) are respectively connected to an output port through the transmission lines (L1 and L2), source ends are connected with a ground line, grid ends are respectively connected with the signal input ends of an path (I) and the path (Q) of a baseband signal (f0); the transmission line (L-1) is connected between the output port and a power supply; and the length of the transmission lines (L1 and L2) are 1/4 of that of the corresponding wavelength of a signal (2f0), the length of the transmission line (L-1) is 1/4 of that of the corresponding wavelength of a signal (4f0). The multi-frequency multiplier comprises a 2n frequency multiplier (1), a 2n frequency multiplier (2) and a transmission line (L), wherein the output ports of the 2n frequency multiplier (1) and the 2n frequency multiplier (2) are connected to be used as the output port of a 2n+1 frequency multiplier, the transmission line (L) is connected between the output port of the 2n+1 frequency multiplier and the power supply, and the length of the transmission line (L) is 1/4 of that of the corresponding wavelength of a signal (2n+1f0). The tera-hertz silica-based quadrupler and the multi-frequency multiplier, provided by invention, have the advantages of high output frequency, pure frequency spectrum, low power consumption and easiness for integration.