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Composite probiotic dietary fiber composition as well as application and health food thereof

A compound probiotic and dietary fiber technology, applied in the fields of application, food science, food ingredients, etc., can solve problems such as single formula, no extension of dietary fiber and probiotic metabolic disorder improvement, insufficient attention to metabolic disorders, etc., to reduce Increased appetite, good increase in body mass index, improvement or relief of elevated total cholesterol and LDL

Pending Publication Date: 2021-12-31
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dietary fiber formula used in the current research is relatively single, most studies use one or two dietary fiber formulas, and most of the studies are dietary fiber or probiotics to improve obesity or glucose and lipid metabolism disorders
[0004] So far, researchers have not paid enough attention to metabolic disorders caused by atypical antipsychotic drugs, or they still focus on metformin and other drugs for weight loss. Most researchers pay attention to the improvement of dietary fiber and probiotics on metabolic disorders, but have not. Extending to the improvement effect of dietary fiber and probiotics on metabolic disorders induced by atypical antipsychotic drugs

Method used

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  • Composite probiotic dietary fiber composition as well as application and health food thereof
  • Composite probiotic dietary fiber composition as well as application and health food thereof
  • Composite probiotic dietary fiber composition as well as application and health food thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of compound probiotic dietary fiber composition

[0025] 1. Weighing and material preparation

[0026] Soluble dietary fiber, insoluble dietary fiber, and probiotics are weighed according to the composition table 1.

[0027] Other preparation examples are similar to the preparation process of this example, as long as the mass ratio of probiotics to dietary fiber is 1:30-40, and the mass ratio of soluble dietary fiber to insoluble dietary fiber is 8-10:1; The number of live bacteria of probiotics is not less than 5.0×10 7 CFU / g. The mass ratio of resistant dextrin, inulin, fructo-oligosaccharide and xylo-oligosaccharide is 30-40:15-20:6-8:5-6. The mass ratio of psyllium husk, seabuckthorn powder and strawberry powder is 10-20:10-15:5-8. The mass ratio of Bifidobacterium longum, Lactobacillus acidophilus and Streptococcus faecalis is 1:-2:1-1.5:1-1.5.

[0028] 2. Mix the above-mentioned powders, specifically put the above-mentioned powders in...

Embodiment 2

[0032] A double-blind, placebo, randomized controlled study comparing the efficacy of dietary fiber and probiotics alone or in combination on atypical antipsychotic-induced metabolic disorders. Divide into four groups: the compound probiotic dietary fiber composition of embodiment 1, dietary fiber group, probiotic group, placebo control group.

[0033] Table 2 shows the main observation results, which are the changes of body weight, BMI, fasting insulin and HOMA-IR of patients before and after treatment. Among them, BMI is weight (kg) divided by the square of height (m), and HOMA-IR is fasting insulin level (mIU / L)×fasting blood glucose (mmol / L) / 22.5.

[0034] Table 3 shows the inter-group comparison of the change values ​​of the main observation indicatorsa

[0035] Table 4 is the secondary observation results including four blood lipids (high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (CHOL)), TESS scale score and appetite...

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Abstract

The invention provides a composite probiotic dietary fiber composition, which is used for relieving weight gain caused by atypical antipsychotic drugs, the composition is composed of dietary fibers and probiotics, the mass ratio of the probiotics to the dietary fibers is 1: (30-40), the dietary fibers comprise soluble dietary fibers and insoluble dietary fibers, the mass ratio of the soluble dietary fibers to the insoluble dietary fibers is (8-10): 1; the viable count of the probiotics is not less than 5.0*10 <7> CFU / g. By using the composite probiotic dietary fiber composition, weight gain caused by atypical antipsychotics can be effectively relieved.

Description

technical field [0001] The present invention relates to the technical field of health food, in particular to a compound probiotic dietary fiber composition and its application and health food. Background technique [0002] Atypical antipsychotic drugs are widely used in the treatment of patients with schizophrenia, bipolar disorder and other mental disorders. Most patients need long-term or even life-long medication to control symptoms and prevent relapse. The patient's treatment brought hope. However, almost all atypical antipsychotic drugs can cause metabolic side effects such as weight gain, elevated blood sugar, dyslipidemia, and insulin resistance. These metabolic side effects have become a major problem in rehabilitation treatment and have attracted more and more attention. So far, the underlying mechanism of metabolic side effects caused by atypical antipsychotic drugs is not clear. It is known that atypical antipsychotic drugs affect metabolism through different and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L33/21A23L33/22
CPCA23L33/135A23L33/21A23L33/22A23V2002/00A23V2400/225A23V2400/113A23V2400/533A23V2200/332A23V2200/328A23V2200/3262A23V2200/30A23V2250/284A23V2250/5114A23V2250/5062
Inventor 吴仁容黄兢刘宸晨
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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