Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sulpiride tablet, and preparation method thereof

A sulpiride and formula technology, which is used in pill delivery, inorganic inactive ingredients, nervous system diseases, etc., can solve the problems of easy adhesion of raw materials to equipment and high loss rate of raw materials

Inactive Publication Date: 2018-03-23
南京迈迪信泽医药科技开发有限公司
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the process of micronizing sulpiride, the inventor encountered unexpected difficulties, such as high loss rate of raw materials, easy adhesion of raw materials on equipment, etc., the present invention has found a solution after research

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sulpiride tablet, and preparation method thereof
  • Sulpiride tablet, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

0.24

[0032] Accurately weigh 0.36 of hypromellose and dissolve in 18g of purified water to form a 2% slurry, mix 100g of sulpiride and 0.24g of talc powder evenly, then micronize the sulpiride with a jet mill, and mix the micronized raw materials with talc powder A total of 100.00g of the mixture, 1.20g of croscarmellose sodium, and 17.20g of lactose monohydrate were placed in a wet granulator, and after adding the binder solution, the stirring speed was set to 400rpm, and the chopping speed was 1500rpm to obtain wet granules. The wet granules are sized through a 20-mesh sieve on a oscillating granulator, placed in a fluidized bed to dry, and the dry granules are sized again through a 20-mesh sieve on a oscillating granulator. The dry granules are mixed with magnesium stearate and then compressed into tablets.

[0033] The dissolution amount of the sulpiride tablet prepared in embodiment 1 in the aqueous medium is as shown in table 1: Table 1: the dissolution amount of ...

Embodiment 2

[0036] Material name

[0037] Accurately weigh 0.72 of hypromellose and dissolve in 36g of purified water to form a 2% slurry, mix 200g of sulpiride and 0.48g of talcum powder evenly, then micronize the raw material of sulpiride with a jet mill, and micronize the sulpiride A total of 100.00g of the mixture with talcum powder, 2.40g of croscarmellose sodium, and 34.40g of lactose monohydrate are placed in a wet granulator. After adding the binder solution, the stirring speed is set to 400rpm, and the chopping speed is 1500rpm to obtain wet Granules, the wet granules are sized through a 20-mesh sieve on a oscillating granulator, placed in a fluidized bed to dry, and the dry granules are sized again on a oscillating granulator through a 20-mesh sieve, and the dry granules are mixed with magnesium stearate Tablet.

[0038] The dissolution amount of the sulpiride tablet prepared in embodiment 2 in aqueous medium is as shown in table 2:

[0039] Table 2: Dissolution of su...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a sulpiride tablet, and a preparation method thereof. The sulpiride tablet comprises, by weight, 50 to 200 parts of sulpiride, 1.2 to 2.4 parts of a disintegrating agent, 15 to 40 parts of an filler, 0.3 to 1 part of an adhesive, and 0.1 to 1 part of a lubricant. The preparation method comprises following steps: sulpiride is subjected to micronization until obtained powderis capable of passing through a mesh of 100 meshes so as to obtain sulpiride fine powder; the sulpiride fine powder is uniformly mixed with the filler; the prepared adhesive is added so as to obtaina soft material; and then pelletizing, drying, size stabilization, lubricant adding and total mixing, performing, and packaging are carried out so as to obtain a finished product.

Description

technical field [0001] The invention relates to the preparation of a pharmaceutical preparation, in particular to a sulpiride tablet and a preparation method thereof. Background technique [0002] Sulpiride, a benzamide compound, is an atypical antipsychotic. In the hypothalamus, pons and medulla oblongata, it can antagonize D1 and D2 receptors, and also has certain antagonistic effects on D3 and D4 receptors. It has an emotional activation effect. It has strong anti-stuppity, withdrawal, hallucinations, delusions and insanity, and has a certain anti-depressant effect. Has a strong central antiemetic effect. Anticholinergic effect is weak, no sedative hypnotic effect and anti-excitement restlessness effect. This product is absorbed from the gastrointestinal tract, and the peak plasma concentration can be reached within 2 hours. After taking this product orally for 48 hours, 30% of the oral dose will be excreted in urine and part of it will be excreted in feces. Plasma ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/40A61K47/02A61P25/18A61P25/24
CPCA61K9/2009A61K9/2054A61K9/2095A61K31/40
Inventor 胡蝶
Owner 南京迈迪信泽医药科技开发有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com