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Sulpride dispersion tablets prepn. method

A technology for dispersible tablets and tablet pressing, which is applied in the directions of active ingredients of heterocyclic compounds, pill delivery, digestive system, etc., can solve the problems of low bioavailability and slow absorption of ordinary tablets, and achieve stable product quality and easy to master production technology. , the effect of convenient use

Inactive Publication Date: 2006-01-25
任巧玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage forms of sulpiride developed at home and abroad include injections, capsules, tablets, etc. Since sulpiride is almost insoluble in water, the absorption of ordinary tablets is slow and the bioavailability is low
The dispersible tablet can disintegrate quickly in water to form a uniform suspension, which is convenient for the elderly, children, and patients with dysphagia and uncooperative patients to take, and the dispersible tablet disintegrates quickly and the drug dissolves quickly, which can improve the bioavailability. There is no economical and practical preparation method for sulpiride dispersible tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Take 100g of sulpiride, 15.4g of carboxymethyl starch sodium (CMS-Na), 2.4g of dextrin, 1.8g of talcum powder, 2.0g of sodium dodecyl sulfate (SDS), 68.0g of microcrystalline cellulose, magnesium stearate 0.16g, an appropriate amount of 5% PVPK60 alcohol solution, crush the prescribed amount of sulpiride, microcrystalline cellulose, 6 / 7 quality sodium carboxymethyl starch, and dextrin through a 0.4mm sieve, mix evenly with a mixer, and use an appropriate amount of 5% PVPK60 alcohol solution is used to make soft materials, mix well, pass through the No. 6 sieve of the granulator to make granules by wet method, and dry with hot air at 65-70°C until the moisture content is less than 5%. Dry granules pass through a No. 6 sieve, add 1 / 7 mass of sodium carboxymethyl starch, talcum powder, sodium lauryl sulfate, magnesium stearate, mix evenly with a mixer, measure the content of semi-finished products, and press them into 1000 piece.

[0009] Pharmacological action: This prod...

Embodiment 2

[0013] Take 100g of sulpiride, 18.8g of carboxymethyl starch sodium (CMS-Na), 2.8g of dextrin, 12.0g of talcum powder, 2.2g of sodium dodecyl sulfate (SDS), 64.0g of microcrystalline cellulose, magnesium stearate 0.16g, 5% PVPK60 alcohol solution is made into 1000 tablets in appropriate amount.

[0014] Method is with embodiment 1.

Embodiment 3

[0016] Take 100g of sulpiride, 12.3g of sodium carboxymethyl starch (CMS-Na), 1.9g of dextrin, 1.6g of talcum powder, 1.8g of sodium dodecyl sulfate (SDS), 56.0g of microcrystalline cellulose, and magnesium stearate 0.16g, 5% PVPK60 alcohol solution is made into 1000 tablets in appropriate amount.

[0017] Method is with embodiment 1.

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PUM

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Abstract

A dispersive tablet of surpiride for treating psychosis is prepared proportionally from surpiride, carboxymethyl starch sodium, microcrystalline cellulose and dextrin through mixing, adding the alcohol solution of polyvinyl pyrrolidone, mixing, wet granulating, drying, adding carboxymethyl starch, talc powder, SDS and magnesium stearate, stirring and tablet pressing.

Description

Technical field: [0001] The invention relates to a preparation method of sulpiride dispersible tablets. The method can be used to prepare sulpiride dispersible tablets which are easy to disintegrate in water, convenient to take and can improve bioavailability. Background technique: [0002] Sulpiride (C15H23N3O4S) was first used in gastroenterology in 1966. In 1967, it was tried on mental patients. In 1969, it was found that when the dose was 100-500mg / d, it was effective for schizophrenia, and the effect on depression was emphasized. The main indications were hallucinations, delusions, and catatonia. It is effective for withdrawn, withdrawn, and indifferent in chronic schizophrenia, and can activate emotions and improve contact. However, the effect on hallucinations and delusions is not as good as that of phenothiazines and butyrophenones. It has a certain effect on depression and menopausal depression. Also used for antiemetic, gastroduodenal ulcer, migraine and vestibu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61K9/20A61P25/24A61P25/06A61P1/04A61P1/08
Inventor 高剑峰任巧玲
Owner 任巧玲
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