41 results about "Isopropoxybenzene" patented technology

This invention provides a compound of formula (I):or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma)glomerulosclerosis, fibrotic disease and inflammation.

A composition curable by a metathesis reaction and comprising an olefin-containing resin system and metathesis catalyst. The resin system comprises siloxane-based oligomers or polymers end-capped and / or tethered with olefin functional groups that are capable of undergoing a metathesis reaction. The composition also includes a ruthenium carbene complex catalyst, whereby the catalyst initiates the metathesis reaction of the composition. The oligomer or polymer may be, for example, one or a combination of a telechelic polydimethylsiloxane end-capped with norbornenylethyl groups, a polydimethylsiloxane tethered and end-capped with norbornenylethyl groups, a tri-functional polydimethylsiloxane end-capped with norbornenylethyl groups, or a quadri-functional polydimethylsiloxane end-capped with norbornenylethyl groups. The catalyst may be, for example, a ruthenium carbene complex, such as 1,3-bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene) dichloro(o-isopropoxyphenylmethylene) ruthenium.

The invention relates to a synthesis method of 2,4-dichloro-5-isopropoxy aniline. The method is characterized in that 2,4-dichloro-5-isopropoxy nitrobenzene with an empirical formula of C9H9NO3Cl2 is used as a raw material, and alcohol is used as a solvent; and in the presence of the action of a composite catalyst, hydrazine hydrate with a molecular formula of N2H4.H2O is added by adopting a dropping mode to synthesize the 2,4-dichloro-5-isopropoxy aniline the empirical formula of which is C9H11NOCl2. The invention not only can obviously improve the yield of the reaction and the product quality and greatly reduce the generation quantity of waste dreg and waste water, but also can simplify the post operation difficulty and shorten the post operation time.

The invention discloses a preparation method of 2,4-dichloro-5-isopropoxy aniline salt. The preparation method is characterized by comprising the following steps of: generating 2,4-dichloro-5-isopropoxy aniline by using 2,4-dichloro-5-isopropoxy nitrobenzene in the presence of polar solvent and water and under the reaction action of stannous chloride, sodium sulfide, sodium sulfite or sodium hyposulfate, adding aromatic hydrocarbon or chloroalkene solvent serving as an extracting agent, extracting, washing, acidifying, filtering, drying, and thus obtaining the 2,4-dichloro-5-isopropoxy aniline salt. Because the reducing agent, the polar solvent and the water are used in the reaction, risk is reduced in the production process of a production workshop, the environment is protected, massive iron cement is not produced, and the aniline salt reaches national standard. Therefore, the method is more reasonable in synthesis process, low in cost and high in quality, and is more suitable for industrialized production.

The invention discloses a method for preparing 3-cyano-4-isopropoxybenzoic acid. A first step, 3-formyl-4-methyl hydroxybenzoate is prepared with methyl parahydroxybenzoate; a second step, 3-cyano-4-methyl hydroxybenzoate is prepared with the 3-formyl-4-methyl hydroxybenzoate; a third step, 3-cyano-4-methyl isopropoxybenzoate is prepared with the 3-cyano-4-methyl hydroxybenzoate; a fourth step, the 3-cyano-4-isopropoxybenzoic acid is prepared with the 3-cyano-4-methyl isopropoxybenzoate. The preparation method of the 3-cyano-4-isopropoxybenzoic acid, which is provided by the invention, has the advantages that 1) the use of the cuprous cyanide of hypertoxic cyanide in a previous process is avoided, and the method is more suitable for industrialization; 2) cyano is prepared by formyl, and the method is high-efficiency and direct, and is suitable for quantity production; 3) all raw materials are cheap and easily obtained, and the cost advantage is obvious.

The invention especially discloses a solvent-free method for hydrogenation preparation of 2,4-dichloro-5-isopropoxy aniline from 2,4-dichloro-5-isopropoxy nitrobenzene, belonging to the field of catalytic hydrogenation production. The method uses 2,4-dichloro-5-isopropoxy nitrobenzene as a raw material and is characterized in that 2,4-dichloro-5-isopropoxy nitrobenzene reacts with hydrogen at a temperature of 80 to 100 DEG C and a pressure of 0.3 to 2.5 MPa in the presence of a catalyst and an auxiliary agent, no solvent is added, and water is separated after completion of the reaction so as to obtain chloroaniline. The catalyst is a noble metal catalyst prepared through independent research and development, and the usage amount of the catalyst is 0.05 to 20% of the mass of 2,4-dichloro-5-isopropoxy nitrobenzene; the auxiliary agent is a mixture of ethanolamine and pyridine, and the usage amount of the auxiliary agent is 0.01 to 10% of the mass of 2,4-dichloro-5-isopropoxy nitrobenzene; and chromatographic purity of obtained 2,4-dichloro-5-isopropoxy aniline is 99.5% or above, a dechlorination amount can be controlled within 0.1%, a conversion rate is 100%, and yield is 95% or above.

This invention provides a compound of formula (I):or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma) glomerulosclerosis, fibrotic disease and inflammation.

Crystalline forms of the sulfate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid (4-isopropoxyphenyl)-amide, which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the sulfate salt are characterized by a variety of properties and physical measurements. As well, methods of producing the sulfate salts, and using such salts to inhibit excessive tyrosine kinase activity in subjects to treat a number of diseases including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer (e.g., leukemia such as acute lymphocytic leukemia), glomerulosclerosis fibrotic diseases and inflammation, and general treatment of cell-proliferative diseases, are also discussed.

The invention discloses a treatment method for recycling oxadiazon etherifying salt waste. The treatment method is characterized by comprising the following treatment steps: adding water to dissolve salt waste; extracting with methylbenzene; preparing bromine employing an acid process; and concentrating and extracting KCl, so as to obtain industrial bromine and crude KCl products, wherein a methylbenzene extracting liquid containing 2,4-dichloro-5-nitro-isopropoxybenzene is used for producing oxadiazon. The problem in treatment of the oxadiazon etherifying salt waste is solved. The method is scientific, reasonable, simple to operate, significant in economic benefits and social benefits and suitable for application in industrial production.

The invention relates to a catalyst system for polymerization of propylene, the catalyst system comprising a Ziegler Natta procatalyst, an organoaluminium cocatalyst, a monoester of an aromatic carboxylic acid as the internal donor and ethyl-4-isopropoxy benzoate as the selectivity control agent. The invention also relates to a process for polymerization using the catalyst system as well as to polymers prepared by the process.

The invention relates to the field of a pesticide synthetic process and discloses a synthetic method of oxadiazon. The synthetic method is used for synthesizing the oxadiazon by carrying out a cyclization reaction on 2,4-dichloro isopropoxy benzhydrazide and dimethyl carbonate under catalysis of sodium alcoholate. The synthetic method disclosed by the invention is carried out in the presence of catalytic amount of the sodium alcoholate by taking the dimethyl carbonate as a carbonylation ring-closing reagent; the dimethyl carbonate is not only taken as a reactant, but also taken as a reaction solvent; a reaction byproduct only has methanol, application of highly-toxic and dangerous chemical substances is avoided, and highly-toxic phosgene is not generated by decomposition, so that no pollution is caused to an environment, and therefore, the synthetic method is safe and environment-friendly, and defects of the conventional process are overcome.

The invention discloses a preparation method of o-isopropoxyphenol. The method is characterized by taking catechol and 2-chloropropane as raw materials, taking a binary-immiscible organic solvent system as a reaction solvent, and preparing the o-isopropoxyphenol by reaction at normal pressure or slight positive pressure in the presence of an acid binding agent and a catalyst. The reaction yield is more than or equal to 94.0% (based on the catechol). The preparation method has the advantages of cheap raw materials, simple process, mild reaction condition, industrialization applicable solvent and low content of the catechol in the reaction solution, thus reducing difficulty of product refinement and greatly reducing energy consumption and three-waste volume.

The invention belongs to a medical intermediate, and particularly relates to a synthesis method of 4-amino-2-hydroxy-3-isopropoxybenzoic acid. The synthesis method of the 4-amino-2-hydroxy-3-isopropoxybenzoic acid is provided for the first time, a synthesis route is provided for the synthesis method of the 4-amino-2-hydroxy-3-isopropoxybenzoic acid, the synthesis method is short in route, reasonable in design, easy to operate and easy to control, and meanwhile the yield of the obtained product is high.

The invention discloses a preparation method of an azole compound N-((5-(3-isopropoxyphenyl)-2H-1, 2, 4-triazole-3-yl)methyl)-N-propylpropan-1-amine. The preparation method utilizes ethyl 3-(3-isopropoxyphenyl)acrylate as a starting raw material and through reduction, acylation, imidization, cyclization, Boc removal and alkylation reaction, a desired product 7 is obtained. The product can be used as a template small molecule to synthesize a variety of compound libraries.

The invention discloses a preparation method of 3-cyano-4-isopropoxybenzoic acid. The preparation method comprises the following steps: step one, preparing 3-formyl-4-phenyl hydroxybenzoate from 4-phenyl hydroxybenzoate; step two, preparing 3-cyano-4-phenyl hydroxybenzoate from the 3-formyl-4-phenyl hydroxybenzoate; step three, preparing 3-cyano-4-phenyl isopropoxybenzoate from the 3-cyano-4-phenyl hydroxybenzoate; step four, preparing the 3-cyano-4-isopropoxybenzoic acid from the 3-cyano-4-phenyl isopropoxybenzoate. The preparation method of the 3-cyano-4-isopropoxybenzoic acid, disclosed by the invention, has the advantages that (1) the use of a highly toxic cyanide-cuprous cyanide in the prior art is avoided, and the preparation method is more suitable for industrialization; (2) cyanogroup is prepared from formyl groups, and the preparation method is efficient and direct and is suitable for large-scale production; (3) all raw materials are cheap and easy to obtain, and the cost advantage is obvious.

The invention discloses a preparation method of 3-cyano-4-isopropoxy methyl benzoate. The preparation method comprises the following steps: step I, preparing 3-aldehyde-4-methyl hydroxybenzoate from methyl p-hydroxybenzoate; step II, preparing 3-cyano-4-methyl hydroxybenzoate from the 3-aldehyde-4-methyl hydroxybenzoate; and step III, preparing the 3-cyano-4-isopropoxy methyl benzoate from the 3-cyano-4-methyl hydroxybenzoate. The preparation method of the 3-cyano-4-isopropoxy methyl benzoate provided by the invention has the advantages: (1) the use of cuprous cyanide of highly-toxic cyanide in the previous process is avoided, and the method is more suitable for industrialization; (2) the cyano is prepared from the aldehyde, so that high efficiency and directness can be realized, and mass production can be realized; and (3) all raw materials are cheap and easy to get, and the cost advantage is apparent.

The invention discloses a method for preparing 3-cyano-4-isopropoxybenzoic acid, comprising the following steps: step 1, preparing 3-aldehyde-4-ethyl hydroxybenzoate from ethyl p-hydroxybenzoate; step 2, preparing 3-cyano-4-ethyl hydroxybenzoate from the 3-aldehyde-4-ethyl hydroxybenzoate; step 3, preparing 3-cyano-4-ethyl isopropoxybenzoate from the 3-cyano-4-ethyl hydroxybenzoate; and step 4, preparing 3-cyano-4-isopropoxybenzoic acid from the 3-cyano-4-ethyl isopropoxybenzoate. The method for preparing the 3-cyano-4-isopropoxybenzoic acid has the following advantages: (1) use of virulent cyanide, namely cuprous cyanide in the prior art is avoided, so the method is more suitable to be industrialized; (2) cyano groups are prepared from aldehyde groups, which is efficient, direct and suitable for mass production; and (3) all the raw materials are cheap and easily available and have obvious advantages in cost.

The invention discloses preparation of a loaded Grubbs catalyst and application of loaded Grubbs catalyst. The preparation is characterized in that: the catalyst is obtained by using the compound obtained by the amidation reaction of 3-3-ethenyl-4-isopropoxyphenyl-propionic acid as a loading precursor and then enabling the compound to carry out exchange complexation respectively with phenyl methylene-bistricyclohexylphosphine-dichlororuthenium or 1, 3-bis 2, 4, 6-trimethylphenyl-2-imidazolidinylidene-dichorobenzenemethylene-tricyclohexylphosphineruthenium; the catalyst is used for the olefin metathesis reaction of N,N-diallyl-4-methylbenzenesulfonamide and has quite strong catalytic activity. Compared with the prior art, the catalyst of the invention is simple in process and convenient in preparation, and can be recycled many times and keep excellent catalytic activity, thereby greatly reducing the heavy metal pollution caused by Grubbs type catalysts to the product of olefin metathesis reaction and developing a new way for green and environmentally-friendly organic synthetic chemistry.

The invention discloses a synthesis method of an oxadiazon intermediate. The synthesis method comprises following steps: m-aminophenol is taken as an initial raw material; m-aminophenol is subjected to an acylation reaction, and a reaction solution A is obtained; the reaction solution A is subjected to a chlorination reaction, and 2,4-dichloro-5hydroxyacetanilide is obtained; 2,4-dichloro-5hydroxyacetanilide is subjected to an etherification reaction, and 2,4-dichloro-5isopropoxyacetaniline is obtained; 2,4-dichloro-5isopropoxyacetaniline is subjected to deprotection, and 2,4-dichloro-5isopropoxyaniline is obtained. With the adoption of the synthesis method of 2,4-dichloro-5-isopropoxyaniline, environmental pollution is avoided, few technological steps are required, and the yield is high.

The invention provides a synthetic process of 2,4-dichloro-5-isopropoxyl phenyl hydrazine. According to the method, 2,4-dichloro-5-isopropoxyl aniline, ketazine and water are used as raw materials, and the 2,4-dichloro-5-isopropoxyl phenyl hydrazine is synthesized through reaction at a certain temperature. Excessive ketazine and water are added in the reaction process to make the 2,4-dichloro-5-isopropoxyl aniline completely react in a reaction system, reduced pressure distillation is adopted to remove the water and the ketazine after reaction is completed, and a solid substance is washed and dried to obtain the 2,4-dichloro-5-isopropoxyl phenyl hydrazine. Compared with a traditional diazo-reaction process for synthesizing the 2,4-dichloro-5-isopropoxyl phenyl hydrazine, the process includes few reaction steps and is simple, the device requirements are not high, reaction is easy to control, the yield is high, the production process is low, waste discharge is little, and the process is a green and environment-friendly production process.

The present invention relates to synthetic technology of artificial propoxur antigen, and belongs to the field of organic chemistry and immunological technology. The organic chemical process of synthesizing propoxur semi-antigen and antigen includes: synthesis of o-propoxy benzoyl chloride, synthesis of gamma-amino butyric acid, synthesis of artificial propoxur antigen, and preserving at -20 deg.c in refrigerator. The antigen has the features of high stability, powerful immunogenicity, etc. and may be used in preparing propoxur antigen with high potency and high compatibility. The present invention has simple preparation process.

The invention discloses long-acting chlorine-resistant fiber cloth for swimsuits. The chlorine-resistant fiber cloth comprises, by weight, 115 parts of polyester fibers, 15 parts of nanometer titanium dioxide, 1 part of tetrakis hydroxymethyl phosphonium sulfate, 2 parts of 5- hydroxy -1-tetralone, 2 parts of 4-cyclohexanone carboxylate, 1.5 parts of 2',4'-acetylphosphoramidothioate acetanilide, 3 parts of sodium pentanesulfonate, 2 parts of 4-isopropyl benzene sulfonyl chloride, 5 parts of 5-amino-2-methyl benzene sulfonic acid, 5 parts of sulfosuccinate butanedioic acid dioctyl phthalate sodium salt, 1 part of softener and 1 part of antioxidants.

The invention discloses a preparation method of pyrocatechol monoisopropyl ether. The method comprises the following steps: by using pyrocatechin and 2-chloropropane as raw materials, and using a compound in a formula (1) as a solvent, carrying out reaction in a high pressure kettle under an effect of an acid acceptor to prepare pyrocatechol monoisopropyl ether. Side reaction between the solvent adopted in the preparation method of the invention and the raw materials is avoided, so that the raw materials are not consumed, and by-products are not produced; therefore, the using amount of the raw materials can be reduced, the production cost is reduced, the purity and the yield of the product also can be improved, and the problems of high production cost, and low purity and yield of the product caused by reaction between the raw materials and the solvent commonly in the prior art are solved; the preparation method has the advantages of simple process, low production cost, and high purity and yield of the product, and is suitable for industrial production; the purity of the product reaches 99% or above, and the yield reaches 90% or above.

The invention discloses a high-leakproofness waterproof sealant for hollow glass. The sealant is prepared from, by weight, 15-25 parts of polydimethylsilane, 7-15 parts of polyisobutene, 6-13 parts of 3-hydroxyl butyronitrile, 4-9 parts of vinyl triethoxy silane, 3-6 parts of (gamma-aminopropyl)triethoxy silane, 2-3 parts of di(3-triethoxysilylpropyl)tetrasulfide, 2-4 parts of polydimethylsiloxane, 1-3 parts of trimethyl silicane, 3-6 parts of vinyl trimethoxy silane, 1-3 parts of borosilicate, 3-7 parts of allyl orthosilicate, 5-10 parts of p-isopropoxy methyl benzoate, 3-5 parts of 2-ethyl acryloyl chloride, 5-8 parts of crosslinking agent and 4-6 parts of plasticizer. The prepared high-leakproofness waterproof sealant for the hollow glass is good in leakproofness and has waterproofness. Meanwhile, the invention further discloses a corresponding preparation method.

The invention discloses a preparation method for 3-cyano-4-isopropoxy phenyl benzoate. The method comprises the following steps: 1) preparing 3-aldehyde-4-phenyl hydroxybenzoate from 4-phenyl-hydroxybenzoate; 2) preparing 3-cyano-4-phenyl-hydroxybenzoate from 3-aldehyde-4-phenyl hydroxybenzoate; and 3) preparing 3-cyano-4-isopropoxy phenyl benzoate from 3-cyano-4-phenyl-hydroxybenzoate. The preparation method for 3-cyano-4-isopropoxy phenyl benzoate disclosed by the invention has the advantages that: 1) the use of cuprous cyanide, which belongs to highly toxic cyanide, used in the prior art is avoided and the method is more suitable for industrialization; 2) the cyano group is prepared from the aldehyde group and the preparation is efficient and direct and is suitable for mass production; and 3) all the raw materials are low-cost and easily acquired and the cost advantage is obvious.

The invention discloses a synthesis method for 2, 4-dichloro-5-isopropoxyaniline. The method comprises the following steps: feeding an auxiliary agent and a catalyst into a reaction kettle, so as to obtain first mixed liquor; feeding an organic solvent and an original compound into the first mixed liquor, and feeding hydrogen into the reaction kettle, so as to ensure that the original compound performs reduction reaction in the condition of the existence of the organic solvent, the auxiliary agent and the catalyst and obtain a reaction product; removing the catalyst and solvent of the reactionproduct, so as to obtain the 2, 4-dichloro-5-isopropoxyaniline. The catalyst adopts a nano-catalyst. The method simplifies synthesis steps of the 2, 4-dichloro-5-isopropoxyaniline, reduces the cost and the recycling difficulty of the catalyst, and meanwhile avoids ricks in traditional technical processes.

The invention discloses a purifying method of propoxur. The purifying method of propoxur comprises following steps: 1, a propoxur solid mixture containing impurities is mixed with an inert solvent, and an obtained mixture is heated until the propoxur solid mixture is melted completely so as to obtain a mixed system; and 2, the mixed system is cooled slowly to the melting-crystal temperature of propoxur, and is allowed to stand until the mixed system is converted into crystal and liquid floating on the crystal completely, and the liquid floating on the crystal is removed so as to obtain purified propoxur. The purifying method is capable of removing impurities 1,2-diisopropoxybenzene and 1-isopropoxy-2-metoxybenzene, operation is simple, and equipment requirement is low.

The invention discloses long-acting chlorine-resistant fiber cloth for swimsuits. The chlorine-resistant fiber cloth comprises, by weight, 115 parts of polyester fibers, 15 parts of nanometer titanium dioxide, 1 part of tetrakis hydroxymethyl phosphonium sulfate, 2 parts of 5- hydroxy -1-tetralone, 2 parts of 4-cyclohexanone carboxylate, 1.5 parts of 2',4'-acetylphosphoramidothioate acetanilide, 3 parts of sodium pentanesulfonate, 2 parts of 4-isopropyl benzene sulfonyl chloride, 5 parts of 5-amino-2-methyl benzene sulfonic acid, 5 parts of sulfosuccinate butanedioic acid dioctyl phthalate sodium salt, 1 part of softener and 1 part of antioxidants.