6 results about "Isopropoxybenzene" patented technology

The subject of the invention is N-substituted derivatives of l-(l-phenyl-3-aryl)-lH-pyrazol-4-yl)methanamine with the general formula 1, where ¥ represents CH or N, R1 represents hydrogen, R2 represents no substituent, R3 represents hydrogen, while R4 represents N-propylbenzamide, benzo[b]furan, dihydrobenzo [b] furan, methylenedioxybenzene, ethyl benzoate, or propyl benzoate, substituted accordingly, their method of production and application, and the method of obtaining and application of N-substituted derivatives of l-(l-phenyl-3-aryl)-IH-pyrazol-4-yl)methanamine with the general formula 1, where Y represents C, CH, or N, R1 represents hydrogen or a methyl group, R2 represents a methyl group or no substituent, R3 represents hydrogen or a methyl group, while R4 represents dimethylpyrazole, methylpyrazole, dimethylimidazo[l,2-a]pyrimidine, or isopropoxybenzene, substituted accordingly. The compounds that are the subject of the invention are obtained through reductive amination using borohydride derivatives as the reducing agent, advantageously sodium triacetoxyborohydride, in the amount of 1.4-2.0 eq, amine in the amount of 1.0-1.1 eq, advantageously in slight excess, base, advantageously triethylamine in the amount of 1.0-1.1 eq (in the case of using amine in the form of hydrochloride), and the starting aldehyde. The reaction is conducted in a nonpolar solvent environment, advantageously dichloroethane at a concentration of about 0.1 M. The crude product is purified by column chromatography on silica gel using a methanol in dichloromethane mixture as the eluent, in concentration ranges from 2% to 5%. In order to obtain a solid form and improve the physicochemical parameters, the free bases are converted into hydrochloride form, and then crystallized from a polar solvent, advantageously ethanol or propanol.

This invention discloses a method for preparing the organic intermediate N'-(2,4-dichloro-5-isopropoxyphenyl)pentanoyl hydrazide, belonging to the field of organic synthesis technology. This invention provides a method for preparing the intermediate under nitrogen protection, using aryl bromide and pentanoyl hydrazide as reactants, and adding alkali, Cu₂O, and N₂. 1 N 2 N'-(2,4-dichloro-5-isopropoxyphenyl)pentanoylhydrazine is generated by a Ullmann coupling reaction involving bis(1-naphthyl)oxalamide, a relevant catalyst, and a water / alcohol solvent, followed by heating. This method utilizes inexpensive and readily available raw materials, has a simple operation process, operates under mild and environmentally friendly conditions, requires minimal post-processing, and is safe and efficient, making it suitable for large-scale industrial production.

The invention belongs to the technical field of preparation of oxadiazon intermediates, and particularly discloses a method for continuously preparing 2, 4-dichloro-5-isopropoxy phenylhydrazine hydrochloride. The method comprises the following steps: respectively precooling a 2, 4-dichloro-5-isopropoxy chlorobenzene diazonium salt solution and a stannous chloride aqueous solution, introducing into a microchannel reactor after precooling, mixing, and reacting to obtain the 2, 4-dichloro-5-isopropoxy phenylhydrazine hydrochloride. The mixing effect of the diazonium salt and the reducing agent stannous chloride is enhanced by utilizing a micro-reaction technology, the reaction speed is increased, the mass transfer and heat transfer effects are improved, and the problems of poor heat and mass transfer effects, low production efficiency, uncontrollable reaction process and accumulation of a large amount of diazonium salt in the existing intermittent reaction are solved; and the existing continuous reaction has the problems of high cost and poor stability.

The invention relates to a process for synthesizing 4-isopropoxy benzene sulfonyl chloride. The process comprises the following two steps of: reacting isopropoxy benzene serving as a raw material with pyridine sulfur trioxide to prepare 4-isopropoxy benzene sulfonic acid pyridine, and directly reacting with thionyl chloride by a one-pot method to obtain the 4-isopropoxy benzene sulfonyl chloride. The method is simple and convenient to operate, less in waste solvent and wastewater amount, and beneficial to realizing continuous production; the process is simple, the raw material cost is low, the reaction stability is good, industrialization is easy to realize, and the market competitiveness of the 4-isopropoxy benzene sulfonyl chloride is effectively improved.

The application discloses a 2,4-dichloro-5-isopropoxyphenylhydrazine hydrochloride continuous flow reaction system and belongs to the technical field of pesticide herbicide technical preparation. The system comprises a raw material feeding pretreatment unit for pretreating raw materials; a diazotization reaction unit connected with the raw material feeding pretreatment unit, a continuous liquid separation unit connected with the diazotization reaction unit; a reduction reaction unit connected with the continuous liquid separation unit and the raw material feeding pretreatment unit respectively; a solid-liquid separation unit connected with the reduction reaction unit; wherein the diazotization reaction unit and the reduction reaction unit are micro-channel reactors, and the units are sequentially connected through pipelines, forming a full-continuous production process from feeding to product centrifugation. The application realizes full-continuous production, significantly shortens the reaction time, improves the efficiency and safety, and enhances the product yield and selectivity.