Cancerous mucus dissolution function and novel anti-tumor application of standardized myrtol

An oil of myrtle, standard technique, used in medicine

Inactive Publication Date: 2018-05-25
李雁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no standard research on mucus-dissolving an

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] (1) Standard myrtle oil dissolution test of cancerous mucus in vitro

[0021] About 30 ml of mucus tissue in the peritoneal cavity of the patient with pseudomyxoma peritonei was collected during the operation, divided into 3 equal parts, and put into three 50 ml sterile centrifuge tubes, numbered 1, 2, and 3. Use a 5 ml sterile syringe to extract 2 capsules of 300 mg / tablet standard myrtle oil enteric-coated soft capsules, and add them to a No. 3 centrifuge tube; use a 5 ml sterile syringe to extract 1 capsule of 300 mg / tablet standard myrtle The medicinal solution in the oil enteric-coated soft capsule was added to the No. 2 centrifuge tube; the No. 1 centrifuge tube was used as a blank control group without any substance added. Cap the three centrifuge tubes tightly, shake vigorously to mix, and incubate at room temperature for 2 hours. Observe changes in mucus viscosity and fluidity. After the incubation, centrifuge at 4 °C, 3000 rpm for 10 minutes, suck out the su...

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Abstract

The invention discloses a mucus dissolution function of standardized myrtol and an anti-tumor function of pharmaceutical composition of the standardized myrtol. The standardized myrtol can effectivelydissolve cancerous mucus, has the anti-tumor function and can improve chemosensitivity in combination with conventional chemotherapy. The standardized myrtol has good safety and has no obvious adverse effects by long-term application.

Description

technical field [0001] The invention relates to a herbal medicine, in particular to a herbal medicine for treating mucus-secreting tumors and the application of the medicine combination thereof, which belongs to the technical field of medicine. Background technique [0002] A variety of malignant tumors have the characteristics of secreting mucus, such as mucinous adenocarcinoma of the digestive tract, signet ring cell carcinoma, mucinous adenocarcinoma of the ovary, mucinous adenocarcinoma of the appendix, pseudomyxoma peritonei, and malignant mesothelioma. Mucin-secreting tumors are more prone to chemotherapy resistance, poor treatment effect and poor prognosis, especially signet ring cell carcinoma. The 5-year survival rate of patients with colorectal signet ring cell carcinoma and peritoneal metastases is only 12%, while the 5-year survival rate of non-mucinous tumors can reach 50%. [0003] The jelly-like component of mucus is mainly mucin, which is a polydisperse macr...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61P35/00
CPCA61K36/61
Inventor 李雁姬忠贺彭开文唐利李鑫宝刘刚张彦斌于洋
Owner 李雁
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