Application of enalapril to preparation of antitumor medicines

An anti-tumor drug, the technology of enalapril, applied in the application field of enalapril in the preparation of anti-tumor drugs, can solve problems such as affecting the prognosis of patients, and achieve control of cardiovascular formation, improvement of cardiovascular side effects, and prevention of cancer. effect of recurrence

Pending Publication Date: 2020-02-11
天津贝罗尼生物科技有限公司
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Problems solved by technology

Although these side effects are within the acceptable risk range as part of cancer treatment, they can have a significant impact on the patient's quality of life and normal treatment progression when receiving othe

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  • Application of enalapril to preparation of antitumor medicines
  • Application of enalapril to preparation of antitumor medicines
  • Application of enalapril to preparation of antitumor medicines

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Embodiment Construction

[0017] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0018] figure 1 As shown, the mode of action of this approach is by using enalapril to inhibit the angiotensin converting enzyme (ACE) responsible for the conversion of Ang I to Ang II, hence known as ACE inhibitors (ACEIs), thus reducing Ang II total amount. Binding of AngII, the AngII type 1 receptor, is responsible for initiating most of the activities associated with RAS, including angiogenesis, cell proliferation and migration. Our proposed method can inhibit the angiogenesis, cell proliferation and other activities in the tumor interior and the peripheral area of ​​the tumor, so as to directly and indirectly inhibit the growth of tumor cells (reduce oxygen and nutrient supply).

[0019] We performed an in vitro study of the expressio...

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Abstract

The invention provides a new application of enalapril to preparation of antitumor medicines. The enalapril can act on a renin angiotensin system (a regulator of a VEGF mediated angiogenesis system), and an ACE/AngII/AT1R route participating in adjusting cell proliferation and cell invasion. Treatment medicines can act on an ACE route participating in adjusting cell proliferation and invasion. Thetreatment manner not only can be used in the whole treatment period but also can be used for preventing cancer recurrence after treatment is successful. The use of the enalapril as an anticancer medicine also contributes to alleviating cardiovascular system side effects of conventional chemotherapy.

Description

technical field [0001] The invention relates to antitumor drugs, in particular to the application of enalapril in the preparation of antitumor drugs. Background technique [0002] Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (vascular permeability factor, VPF), is a highly specific factor that promotes the growth of vascular endothelial cells. Matrix degeneration, vascular endothelial cell migration, proliferation and angiogenesis. Controlling tumor growth by inhibiting angiogenesis, which prevents cancer cells from growing and spreading, has long been explored in cancer biology. [0003] Because cancer cell proliferation requires a "vascular phenotype" switch and increased production of a number of angiogenic factors, including vascular endothelial growth factor (VEGF) and factors that stimulate VEGF. The angiotensin system (RAS) is such a system and is involved in blood pressure regulation. Angiotensin II (Ang II) is the main eff...

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Application Information

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IPC IPC(8): A61K31/40A61P35/00A61P9/00
CPCA61K31/40A61P35/00A61P9/00
Inventor 王予
Owner 天津贝罗尼生物科技有限公司
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