3 results about "Cardiac pathology" patented technology

The invention belongs to the technical field of animal model construction, and relates to a construction method and application of an arrhythmic cardiomyopathy zebrafish model. An sgRNA targeting exon 2 of a zebrafish brd4 gene is designed, a mixture of sgRNA and Cas9 protein is used to mutate the brd4 gene of a wild-type zebrafish fertilized egg, the obtained F0 generation zebrafish is mated with a wild-type zebrafish, and positive heterozygous F1 generation zebrafish are screened out from the born zebrafish, which is an arrhythmic cardiomyopathy zebrafish model; through cardiac pathology, cardiac function detection, heart rate and swimming test indicators, it is confirmed that the brd4 heterozygous mutant zebrafish can develop arrhythmic cardiomyopathy. The model construction method is simple, efficient and has a high success rate, and provides great help and convenience for evaluating or screening drug research for treating arrhythmic cardiomyopathy.

A phonocardiogram apparatus and related method for diagnosis of cardiac pathologies through advanced sound recording and analysis. This apparatus utilizes a grid of microphones embedded in a fabric and positioned over the patient's chest and back to capture heart, lung, and neck sounds from multiple locations. An artificial intelligence (AI) based algorithm is employed to determine the most relevant microphones based on the patient's unique anatomy, thereby optimizing sound collection for diagnostic purposes. The collected sounds undergo a series of pre-processing and machine learning analyses to diagnose cardiac abnormalities such as aortic stenosis, murmurs, and extra systoles, create cardiac auscultatory signatures and allow longitudinal monitoring by clinicians or patients themselves for comparison over time.

This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention.