37 results about "Colon inflammation" patented technology

The invention relates to the field of traditional Chinese medicines, in particular to a medicament for treating acute and chronic colonitis, which is used for solving the problems of temporary relieving of symptoms, incapability of healing, large side effects and the like existing in the conventional colonitis treating medicament. Chinese medicinal raw materials prepared into active ingredients consist of the following components in parts by weight: 10-20 parts of astragalus, 15-20 parts of Chinese magnoliavine fruit, 10-15 parts of Chinese pulsatilla root, 10-15 parts of hairyvein agrimonia herb and bud, 10-15 parts of weeping forsythia, 5-10 parts of amomum fruit, 5-8 parts of fructus crataegi, 5-8 parts of medicated leaven and 2-5 parts of dried ginger. Cold and warm materials as well as ascending and descending materials supplement each other in a prescription, so that various types of acute and chronic colonitis can be cured in a short period of time, a remarkable curative effect is achieved, the curative rate is up to 90 percent, and relapse after curing is prevented; and moreover, the medicament belongs to a pure Chinese medicinal preparation, is low in cost, is easy to accept by patients, and is worthy of clinical popularization and application.

The invention provides an anthocyanin nanoparticle based on a marine polysaccharide carrier. The marine polysaccharide, food-derived fluorescent nanoparticle, and hyaluronic acid are used as a composite carrier to combine with anthocyanin. The preparation method is: S1, dissolving sodium alginate in phosphoric acid In salt-buffered saline, add EDC and HOBt and food-derived fluorescent nanoparticles in sequence to obtain a fluorescent-alginic acid complex; S2, adding the fluorescent-alginic acid complex to a mixture of DMF and DCM, then adding DIC and DMAP; S3, removing the solvent after adding anthocyanin and the hyaluronic acid; S4, removing unreacted small molecules, and freeze-drying. The present invention can improve the stability of anthocyanin, control the slow release of anthocyanin, has the characteristics of fluorescent tracer, can be used as a fluorescent marker for in vivo imaging of animal tissues and organs, and can also be targeted for delivery to the colon of animals to alleviate the symptoms induced by DSS. Inflammatory damage to the colon.

The invention belongs to the field of biomedicine, and discloses the application of Lactobacillus johnsonii in the preparation of medicaments for preventing and / or treating inflammatory bowel disease, and a method for preventing and / or treating inflammatory bowel disease of oral probiotics comprising Lactobacillus johnsonii strains such as UMNLJ22. In the present invention, Lactobacillus johnsonii can significantly improve spleen hyperplasia, colon shortening, colonic mucosal hyperplasia and colon inflammatory response in the inflammatory bowel disease mouse model induced by Citrobacter rodentium, and it is found that Lactobacillus johnsonii can significantly Alleviate inflammatory bowel disease in mice, so as to be used for the development and preparation of medicaments for preventing and / or treating inflammatory bowel disease.

The invention discloses a microanaerobic bacterium for treating colon inflammation, and the microanaerobic bacterium is Helicobacter hepatica. The present invention also provides the application of the microanaerobic bacteria in the preparation of drugs for preventing and / or treating colon inflammation and the application in the preparation of drugs for preventing colon cancer. In the present invention, the inventors clearly proposed for the first time that Helicobacter helicobacter can treat inflammatory enteritis and prevent colon cancer. It provides important clinical value and reference significance for the intestinal flora to diagnose and treat colorectal cancer.