Preparation method and application of Hedyotis diffusa extract

Through the process of extracting and separating and controlling the ingredient content of the White Flower Snake Tongue Extract, the stability and safety of the White Flower Snake Tongue Extract in daily chemical products is solved, and efficient, safe soothing and anti-inflammatory effects are achieved.

CN119235735BActive Publication Date: 2025-09-02GUANGZHOU JIANENG BIOTECHNOLOGY CO LTD +1
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Patent Information

Application Number
CN202411755728.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-03
Publication Date
2025-09-02
Estimated Expiration
2044-12-03

AI Technical Summary

Technical Problem

The content of cycloalether terpenes in the extract of White Flower Snake Tongue is high, has strong irritation, and is not very stable in the solution. It is difficult for the existing technology to obtain stable, safe and effective daily chemical products.

Method used

The cycloalether glycosides in the cyperidus phylla is refined and separated by a specific process, and the content of other components is controlled, and the cyperidus phylla is prepared, including ultrasonic extraction of reduced pressure, centrifugal separation, concentration of reduced pressure, acid-regulating pH, membrane filtration, ion exchange resin column chromatography and molecular blotting polymerization and adsorption separation, to obtain the cyperidus extract of specific components.

Benefits of technology

It improves the stability and safety of the extract, enhances the soothing and anti-inflammatory effects, reduces the decomposition of active ingredients, and provides safe and gentle daily chemical products raw materials.

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Abstract

The invention discloses a Hedyotis diffusa extract, comprising a hedyotis diffusa glycoside content of 2500-4000 ppm, deacetylated hedyotis diffusa methyl ester, scutellariae glycoside methyl ester, and hedyotis diffusa glycoside content of 4500-6500 ppm, a total flavonoid content of less than 100 ppm, no characteristic color reaction for anthraquinone identification, hedyotis diffusa acid content of less than 100 ppm, deacetylated hedyotis diffusa acid content of less than 100 ppm, and geniposide acid content of less than 100 ppm, and a pH value of 6.0-7.0. The extract is obtained by vacuum ultrasound, centrifugation, and vacuum concentration, followed by acid adjustment to a pH of 2.5-3.0, followed by aging, membrane filtration, and purification by ion exchange column chromatography to obtain a permeate A and a Hedyotis diffusa alkaloid eluate J1. The permeate A is filtered through a membrane, separated by molecular imprinting polymerization adsorption, vacuum concentrated, and ultrafiltered. Finally, the pH is adjusted to 6-7 with J1, and the extract is sterilized by heat preservation.
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