Method for improving flexibility of polypeptide membrane by polylactic acid and polydioxanone

A technology of polydioxanone and polylactic acid, which is applied in the field of polymer film preparation to achieve the effects of easy mastery, simple operation, and improved flexibility

Inactive Publication Date: 2014-06-18
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the flexibility of polypeptide membranes by using polylactic acid and polydioxanone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0018] Add 20 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 0.9 grams of 2,4-toluene diisocyanate and 280 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add the above Dibutyltin dilaurate with a total weight of 3‰ of reactants, under an inert atmosphere, stirred and reacted at 50°C for 40 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;

[0019] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:

[0020] Add 15 g of poly(r-benzyl-L-glutamate) containing terminal -NCO groups, 11.8 g of polylactide monolauryl ether with a molecular weight of 3000, and 420 ml of dimethyl base sulfoxide solvent, then add dibutyltin dilaurate with a total weight of 3‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 40°C for 50 minutes, terminate the reaction, and obta...

Embodiment 2

[0025] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0026] Add 20 g of poly(r-ethyl-L-glutamate) with a molecular weight of 70,000, 1.02 g of 2,4-toluene diisocyanate, and 217 ml of 1,1,2-trichloroethane solvent into a dry reactor In addition, dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants was added, under an inert atmosphere, the reaction was stirred at 52°C for 50 minutes, the reaction was terminated, and the excess diisocyanate was removed by dialysis to obtain the target product;

[0027] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:

[0028] 15 g of poly(r-ethyl-L-glutamate) containing terminal -NCO groups, 17.1 g of poly(lactic acid monolauryl ether) with a molecular weight of 4000 and 425 ml of 1,1 , 2-trichloroethane solvent, and then add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 45°C for 60 minutes, termin...

Embodiment 3

[0033] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0034] Add 20 grams of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 0.96 grams of 2,4-toluene diisocyanate and 150 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add the above reaction Dibutyltin dilaurate with a total weight of 5‰, under an inert atmosphere, stirred and reacted at 55°C for 60 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;

[0035] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:

[0036] Add 15 g of poly(r-methyl-L-glutamate) containing terminal -NCO groups, 20.1 g of polylactide monolauryl ether with a molecular weight of 5000, and 365 ml of dimethyl sulfoxide solvent, and then add dibutyltin dilaurate with a total weight of 5‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 50°C for 70 minutes, terminate the reaction, and obtain t...

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PUM

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Abstract

The invention discloses a method for improving the flexibility of a polypeptide membrane by polylactic acid and polydioxanone. The method comprises the following steps: (1) adding polypeptide homopolymer, diisocyanate, a catalyst and a solvent into a drying reactor, stirring to react for 40-60 minutes at 50-55 DEG C, and removing excessive diisocyanate by a dialysis method to obtain polypeptide homopolymer containing -NCO-terminated group; (2) adding the polypeptide homopolymer containing -NCO-terminated group, a catalyst and a solvent into the drying reactor, adding polylactic acid monododecyl ether, and stirring to react for 50-70 minutes at 40-50 DEG C to obtain polypeptide-poly-polylactic acid diblock copolymer; (3) adding the polypeptide-poly-polylactic acid diblock copolymer, polydioxanone and a solvent into the drying reactor, stirring and mixing for 60-70 minutes at 40-50 DEG C, forming a membrane by using a tape casting method, and drying to obtain a target product. The preparation process is simple, and the flexibility of the modified membrane is greatly improved.

Description

technical field [0001] The invention relates to a method for improving the flexibility of a polypeptide film, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide is relatively stiff and lacks good flexibility, so to a certain extent limits its application. Poly(D,L) lactic acid and polydioxanone have good biocompatibility and biodegradability, are relatively soft and have good blending properties with each other. First, the polylactic acid segment is introduced into the polypeptide segment to form a polypeptide-polylactic acid diblock copolymer, and then the polydioxanone segment is added to the polypeptide-polylactic acid diblock copolymer to form a blend In order to improve the blendability of the polypeptide, the modified polypeptide film is prepared, thereby greatly improving th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L75/06C08L67/00C08G18/76C08G18/60C08G18/42
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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