Method for improving flexibility of polypeptide membrane by polylactic acid and polydioxanone
A technology of polydioxanone and polylactic acid, which is applied in the field of polymer film preparation to achieve the effects of easy mastery, simple operation, and improved flexibility
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Embodiment 1
[0017] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:
[0018] Add 20 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 0.9 grams of 2,4-toluene diisocyanate and 280 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add the above Dibutyltin dilaurate with a total weight of 3‰ of reactants, under an inert atmosphere, stirred and reacted at 50°C for 40 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;
[0019] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:
[0020] Add 15 g of poly(r-benzyl-L-glutamate) containing terminal -NCO groups, 11.8 g of polylactide monolauryl ether with a molecular weight of 3000, and 420 ml of dimethyl base sulfoxide solvent, then add dibutyltin dilaurate with a total weight of 3‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 40°C for 50 minutes, terminate the reaction, and obta...
Embodiment 2
[0025] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:
[0026] Add 20 g of poly(r-ethyl-L-glutamate) with a molecular weight of 70,000, 1.02 g of 2,4-toluene diisocyanate, and 217 ml of 1,1,2-trichloroethane solvent into a dry reactor In addition, dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants was added, under an inert atmosphere, the reaction was stirred at 52°C for 50 minutes, the reaction was terminated, and the excess diisocyanate was removed by dialysis to obtain the target product;
[0027] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:
[0028] 15 g of poly(r-ethyl-L-glutamate) containing terminal -NCO groups, 17.1 g of poly(lactic acid monolauryl ether) with a molecular weight of 4000 and 425 ml of 1,1 , 2-trichloroethane solvent, and then add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 45°C for 60 minutes, termin...
Embodiment 3
[0033] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:
[0034] Add 20 grams of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 0.96 grams of 2,4-toluene diisocyanate and 150 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add the above reaction Dibutyltin dilaurate with a total weight of 5‰, under an inert atmosphere, stirred and reacted at 55°C for 60 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;
[0035] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:
[0036] Add 15 g of poly(r-methyl-L-glutamate) containing terminal -NCO groups, 20.1 g of polylactide monolauryl ether with a molecular weight of 5000, and 365 ml of dimethyl sulfoxide solvent, and then add dibutyltin dilaurate with a total weight of 5‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 50°C for 70 minutes, terminate the reaction, and obtain t...
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