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Medicine carrying nanofiber membrane and preparation and application methods thereof

A drug-loaded nanofiber membrane technology, applied in the field of fibrous membranes, can solve problems such as inability to achieve linear release, and achieve the effects of drug controlled release, good swelling performance, and linear controlled release

Active Publication Date: 2019-06-18
SHENZHEN GUANGYUAN BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug-loaded nanofibrous membrane prepared by this method has the characteristics of simple structure and excellent drug sustained release performance, but the drug in the fiber membrane will be released exponentially and cannot be released linearly.

Method used

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  • Medicine carrying nanofiber membrane and preparation and application methods thereof
  • Medicine carrying nanofiber membrane and preparation and application methods thereof
  • Medicine carrying nanofiber membrane and preparation and application methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] This embodiment provides a drug-loaded nanofiber membrane, the composition of the drug-loaded nanofiber membrane includes polylactic acid-glycolic acid copolymer fibers, polydioxanone fibers, and paclitaxel; the paclitaxel is dispersed in polylactic acid- In the glycolic acid copolymer fiber; the polylactic acid-glycolic acid copolymer is a mixture of high molecular weight polylactic acid-glycolic acid copolymer (MW=150000) and low molecular weight polylactic acid-glycolic acid copolymer (MW=80000), two The mass ratio of the two is 25:75; the total mass of the polydioxanone fiber is 10% of the total mass of the polylactic acid-glycolic acid copolymer fiber; the total mass of paclitaxel is 10% of the total mass of the fiber.

[0063] Its preparation method is:

[0064] (1) Mix paclitaxel, polylactic acid-glycolic acid copolymer and acetone, then mix polydioxanone and hexafluoroisopropanol to obtain two mixed solutions;

[0065] (2) The two mixed solutions in step (1) we...

Embodiment 2

[0070] This embodiment provides a drug-loaded nanofiber membrane, the composition of the drug-loaded nanofiber membrane includes polylactic acid-glycolic acid copolymer fibers, polydioxanone fibers and 5-fluorouracil; the 5-fluorouracil is dispersed In the polylactic acid-glycolic acid copolymer fiber; the polylactic acid-glycolic acid copolymer is high molecular weight polylactic acid-glycolic acid copolymer (MW=100000) and low molecular weight polylactic acid-glycolic acid copolymer (MW=40000) The mixture, the mass ratio of the two is 15:85; the total mass of polydioxanone fiber is 15% of the total mass of polylactic acid-glycolic acid copolymer fiber; the total mass of 5-fluorouracil is 15% of the total mass of fiber 20%.

[0071] Its preparation method is:

[0072] (1) Mix 5-fluorouracil, polylactic acid-glycolic acid copolymer and acetone, then mix polydioxanone and hexafluoroisopropanol to obtain two mixed solutions;

[0073] (2) The two mixed solutions in step (1) wer...

Embodiment 3

[0078] This embodiment provides a drug-loaded nanofiber membrane, the composition of the drug-loaded nanofiber membrane includes polylactic acid-glycolic acid copolymer fiber, polydioxanone fiber and capecitabine; the capecitabine The strands are dispersed in the polylactic acid-glycolic acid copolymer fibers; the polylactic acid-glycolic acid copolymers are high molecular weight polylactic acid-glycolic acid copolymers (MW=120000) and low molecular weight polylactic acid-glycolic acid copolymers (MW= 60000), the mass ratio of the two is 5:95; the total mass of polydioxanone fibers is 1% of the total mass of poly(lactic-co-glycolic acid) fibers; the total mass of capecitabine is 1% of the total mass of fibers 15% of the total mass.

[0079] Its preparation method is:

[0080] (1) Mix capecitabine, polylactic acid-glycolic acid copolymer and acetone, then mix polydioxanone and hexafluoroisopropanol to obtain two mixed solutions;

[0081] (2) The two mixed solutions in step (1...

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Abstract

The invention relates to a medicine carrying nanofiber membrane and preparation and application methods thereof. The medicine carrying nanofiber membrane is composed of polylactic acid-hydroxyacetic acid copolymer fiber, polydioxanone fiber and medicines, wherein the medicines are dispersed inside the polylactic acid-hydroxyacetic acid copolymer fiber. The preparation method of the medicine carrying nanofiber membrane comprises (1) mixing the medicines and polylactic acid-hydroxyacetic acid copolymer with solvent and then mixing polydioxanone with solvent to obtain two mixed solutions; (2) independently loading the two mixed solutions and performing electrostatic spinning with multi-spinneret electrostatic spinning equipment to obtain the medicine carrying nanofiber membrane. The obtainedmedicine carrying nanofiber membrane is prepared through electrostatic spinning and is stable in property, high in porosity and similar to extracellular matrices, and when applied to postoperative stumps, can be extracted without secondary surgery, be degradable in vivo and achieve linear release of the medicines.

Description

technical field [0001] The invention belongs to the technical field of fiber membranes, and in particular relates to a drug-loaded nanofiber membrane and its preparation method and application. Background technique [0002] After surgery, drugs are usually combined with oral and intravenous injections. Whether it is antibiotics to prevent infection or chemotherapy drugs to prevent tumor spread and recurrence, oral or intravenous injections have disadvantages such as low utilization rate and large toxic and side effects, especially for For the protection of surgical wounds or lesions, the local drug concentration is difficult to reach the actual required onset concentration, resulting in poor therapeutic effect. Absorbable drug-loaded films can effectively solve this problem, and drugs can be absorbed by tissues in situ to prevent local wound infection or tumor metastasis. After the release of the drug, the carrier will be further absorbed by the body, so as to effectively a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/435D01D5/00
CPCD04H1/728D04H1/435A61K31/5383A61K31/513A61K31/545A61K31/337A61K31/7068A61K31/496D04H1/4382D01F6/84D01F6/625D01F1/10D01D5/0038A61K9/0092A61K47/34D01D5/0069D10B2509/022
Inventor 韩志超许杉杉伍家恩
Owner SHENZHEN GUANGYUAN BIOMATERIAL CO LTD
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