A kind of preparation method of biodegradable filling material and its product and application

Abstract

The invention relates to a method for preparing biodegradable filling materials, a product prepared by the aid of the method and application of the product. The method mainly includes steps of (1), mixing matrix materials and dispersion-phase materials according to a mass ratio of 10:0-6:4 with one another and dissolving the matrix materials and the dispersion-phase materials in organic solvents to obtain high-polymer organic solvents; (2), treating the high-polymer organic solvents by the aid of a mechanical process or an emulsification process to obtain a micro-sphere. The matrix materials comprise polydioxanone; the dispersion-phase materials comprise a type of or a plurality of types of poly-L-lactic acid, polycaprolactone, polylactic acid and polyglycolic acid. The method, the product and the application have the advantages that the method is easy to implement, low in cost and good in repeatability, the product comprises tiny and stable particles, and the micro-sphere prepared by the aid of the method has similar and controllable particle sizes, is good in filling performance and tissue compatibility and is safe and degradable; the product can be degraded slowly, the degradation time can be regulated and controlled according to selection of the types and the adding proportions of the dispersion-phase materials; the micro-sphere can be used for preparing freeze-dried powder preparations and gel preparations, and the product is convenient to transport, store and clinically use.

Description

technical field

[0001] The invention belongs to the field of material technology, and in particular relates to a preparation method of a biodegradable filling material and its product and application. Background technique

[0002] With the development of society and the improvement of living standards, more and more people begin to pay attention to facial wrinkles and aging problems. The plastic surgery industry is rising rapidly. In 2009, China has become the third largest plastic surgery country in the world. At present, the scale of China's medical beauty market exceeds 500 billion, with an annual growth rate of nearly 20%. It is expected to exceed 800 billion yuan in 2018 and break through one trillion yuan in 2019. Among them, the total output value of China's medical aesthetics market in 2014 was 553 billion yuan, of which injection cosmetics accounted for a considerable proportion of plastic surgery, and because of the advantages of immediate effect of injection cos...

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