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Nano-hydroxyapatite-modified polyurethane urea bone repair material and preparation method thereof

A technology of nano-hydroxyapatite and repair materials, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve problems such as unfavorable cell growth, achieve good biocompatibility, excellent performance, and promote bone regeneration

Active Publication Date: 2018-08-21
济南羽时信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pores suitable for the growth of human bone tissue are 100-400 μm, but the injectable composite bone material contains a large amount of porogen, which is not conducive to cell growth, and the synthesis of bone material in this patent also uses collagen, which also has hidden dangers of viruses and immune reactions

Method used

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  • Nano-hydroxyapatite-modified polyurethane urea bone repair material and preparation method thereof
  • Nano-hydroxyapatite-modified polyurethane urea bone repair material and preparation method thereof
  • Nano-hydroxyapatite-modified polyurethane urea bone repair material and preparation method thereof

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preparation example Construction

[0058] The preparation method of LBL is: under the protection of dry nitrogen and mechanical stirring, add 1,4-butanediamine dropwise to L-lysine diisocyanate (-NCO:-NH 2 =8:1, molar ratio), after reacting at room temperature for 2h, add four times the volume of n-hexane to the reaction product, after stirring evenly, obtain a white solid by suction filtration, wash with n-hexane repeatedly until the filtrate IR detects that there is no -NCO absorption Peak (2270cm -1 ), vacuum-dried to constant weight to obtain white powder LBL. LBL's 1 H NMR structure characterization results: 1 H NMR (DMSO-D6, ppm): 1.27-1.32 (m, 10H, CH 3 CH 2 and C H 2 CH 2 CHNCO), 1.52-1.55(m,8H, CH 2 CH 2 NH),1.75(q,4H, CH 2 CHNCO),3.08-3.16(t,8H, CH 2 NH), 4.08-4.15 (m, 6H, CH-NCO and CH 3 C H 2 ), 5.95-6.04 (br, N H ).

[0059] The preparation method of LHL is: under the protection of dry nitrogen and mechanical stirring, add 1,6-butanediamine dropwise to L-lysine diisocyanate ...

Embodiment 1

[0061] 4.5g double-terminal hydroxyl PPDO (3mmol, M n =1500) was dissolved in 20mL DMF, protected by dry nitrogen, mechanically stirred, adding 2.25g of nano-sized nano-hydroxyapatite (average particle size is 50nm) in batches, stirred evenly, heated up to 80°C, added chain extender LBL DMF solution (0.4g / mL), control the molar ratio of -NCO to -OH to be 1.3:1, keep the reaction temperature until the -NCO content is close to the theoretical value, about 4.5h, dilute DMF to 15g / 100mL, drop to room temperature, and then Add 0.397mmol pentaerythritol and stir well. Slowly pour into the mold, react at room temperature for 96 hours, and cross-link. Soak the molded product in 3 times the volume of deionized water, soak for 4 hours, repeat three times, then soak in 3 times the volume of absolute ethanol, soak for 4 hours, repeat three times, dry at room temperature to constant weight, and obtain the honeycomb bone repair material a.

Embodiment 2

[0063] 6.0g double-terminal hydroxyl PPDO (3mmol, M n=2000) was dissolved in 20mL DMF, protected by dry nitrogen, mechanically stirred, adding 3.0g of nano-sized nano-hydroxyapatite (average particle size is 60nm) in batches, stirred evenly, heated up to 80°C, added chain extender LBL DMF solution (0.4g / mL), control the molar ratio of -NCO to -OH to be 1.3:1, keep the reaction temperature until the -NCO content is close to the theoretical value, about 4.5h, dilute DMF to 15g / 100mL, drop to room temperature, and then Add 0.454mmol pentaerythritol and stir well. Slowly pour into the mold, react at room temperature for 96 hours, and cross-link. Soak the molded product in 4 times the volume of deionized water, soak for 4 hours, repeat three times, then soak in 4 times the volume of absolute ethanol, soak for 4 hours, repeat three times, dry at room temperature to constant weight, and obtain the honeycomb bone repair material b.

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Abstract

The invention discloses a nano-hydroxyapatite-modified polyurethane urea bone repair material and a preparation method thereof. The preparation method comprises the following steps: adding nano-hydroxyapatite into a dihydroxy-terminal polydioxanone solution, uniformly dispersing and then heating; adding a diisocyanate chain extender containing a ureido structure and carrying out chain extension reaction to obtain a dual-terminal isocyanate prepolymer; carrying out self-crosslinking reaction on the dual-terminal isocyanate prepolymer and polyatomic alcohol, removing a solvent and carrying out vacuum drying at normal temperature to obtain the nano-hydroxyapatite-modified polyurethane urea bone repair material, wherein the chain extension reaction is a chemical reaction that hydroxyl reacts with isocyanato to generate a mephenesin carbamate group. According to the method, a polyurethane-urea high polymer material is integrated with nano-hydroxyapatite with high biocompatibility to obtaina framework material with high porosity and proper aperture size; and the obtained bone repair material has the advantages of controllable degradation performance, good repair effect, high mechanicalproperty, high biocompatibility, absorbable degradation product and the like.

Description

technical field [0001] The invention relates to the technical field of medical polymer composite materials, in particular to a nano-hydroxyapatite-modified polyurethane urea bone repair material and a preparation method thereof. Background technique [0002] For a long time, bone repair materials mainly adopt autologous or allogeneic bone grafting. However, there are serious defects in the source of autologous bone graft. Taking bone from autologous heterotopia is tantamount to tearing down the east wall to make up for the west wall, making patients prone to postoperative complications, and the failure rate is as high as 10% to 30%. Allogeneic bone transplantation is quite difficult and expensive in terms of material selection and storage, and it is also prone to immune rejection, HIV infection, etc., and has a higher failure rate. At the same time, allograft bone is replaced slowly, and the volume of new bone is relatively small. In order to overcome various problems exi...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/12A61L27/50A61L27/54A61L27/56A61L27/58C08G18/64C08G18/38C08G18/78
CPCA61L27/12A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/112A61L2300/412A61L2400/12A61L2430/02C08G18/3885C08G18/64C08G18/7825C08L75/04
Inventor 时玉祥侯昭升
Owner 济南羽时信息科技有限公司
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