Method for improving hydrophilia and flexibility of polypeptide membrane through polydioxanone and polyethylene glycol
A technology of polydioxanone and dioxanone monolauryl ether, which is applied in the field of polymer film preparation to achieve the improvement of hydrophilicity and flexibility of the polypeptide modified film, simple operation, and easy The effect of mastering
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Embodiment 1
[0017] 1) Synthesis of Polypeptide-Polydioxanone Block Copolymer
[0018] 16.2 g of poly(r-benzyl-L-glutamate) (molecular weight: 80,000) and 7 g of carboxy-terminated polydioxanone monolauryl ether (molecular weight: 3000), add 300 ml DMSO, then add 0.048 g N,N' -Dicyclohexylcarbodiimide, stirred and reacted at 25°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;
[0019] 2) Synthesis of polyethylene glycol-polydioxanone block copolymer
[0020] Add 3 grams of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 5000) and 9 grams of carboxyl-terminated polydioxanone monolauryl ether (molecular weight: 3000) in the dry reactor, add 160 ml dimethyl sulfoxide, then add 0.145 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the target product;
[0021]...
Embodiment 2
[0025] 1) Synthesis of Polypeptide-Polydioxanone Block Copolymer
[0026] 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight 85,000) and 7 g of carboxy-terminated polydioxanone monolauryl ether (molecular weight 3,500) were added to the dry reactor ), add 305 ml dimethyl sulfoxide, then add 0.031 g N,N'-diisopropylcarbodiimide, under inert atmosphere, stir and react at 27°C for 4 days, terminate the reaction, filter, dialyze, dry , get the target object;
[0027] 2) Synthesis of polyethylene glycol-polydioxanone block copolymer
[0028] Add 3 grams of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 6000) and 9 grams of carboxyl-terminated polydioxanone monododecyl ether (molecular weight: 3500) in the dry reactor, add 155 ml dimethyl sulfoxide, then add 0.08 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the target product;
[0029] 3)...
Embodiment 3
[0033] 1) Synthesis of Polypeptide-Polydioxanone Block Copolymer
[0034] 16.5 g of poly(r-methyl-L-glutamate) (molecular weight 90,000) and 7 g of carboxy-terminated polydioxanone monolauryl ether (molecular weight 4,000) were added to the dry reactor ), add 310 ml dimethyl sulfoxide, then add 0.046 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, and stir the reaction at 30°C for 3 days under an inert atmosphere to terminate the reaction , by filtering, dialysis and drying, the target object is obtained;
[0035] 2) Synthesis of polyethylene glycol-polydioxanone block copolymer
[0036] Add 3.1 grams of amino-terminated polyethylene glycol monomethyl ether (molecular weight is 7000) and 9.2 grams of carboxy-terminated polydioxanone monododecyl ether (molecular weight is 4000) in the dry reactor, add 158 ml dimethyl sulfoxide, then add 0.141 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir the reaction at 35°C for 2 days, then terminate ...
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