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Method for improving hydrophilia and flexibility of polypeptide membrane through polydioxanone and polyethylene glycol

A technology of polydioxanone and dioxanone monolauryl ether, which is applied in the field of polymer film preparation to achieve the improvement of hydrophilicity and flexibility of the polypeptide modified film, simple operation, and easy The effect of mastering

Inactive Publication Date: 2015-04-01
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the hydrophilicity and flexibility of the polypeptide film with polydioxanone and polyethylene glycol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Synthesis of Polypeptide-Polydioxanone Block Copolymer

[0018] 16.2 g of poly(r-benzyl-L-glutamate) (molecular weight: 80,000) and 7 g of carboxy-terminated polydioxanone monolauryl ether (molecular weight: 3000), add 300 ml DMSO, then add 0.048 g N,N' -Dicyclohexylcarbodiimide, stirred and reacted at 25°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0019] 2) Synthesis of polyethylene glycol-polydioxanone block copolymer

[0020] Add 3 grams of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 5000) and 9 grams of carboxyl-terminated polydioxanone monolauryl ether (molecular weight: 3000) in the dry reactor, add 160 ml dimethyl sulfoxide, then add 0.145 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the target product;

[0021]...

Embodiment 2

[0025] 1) Synthesis of Polypeptide-Polydioxanone Block Copolymer

[0026] 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight 85,000) and 7 g of carboxy-terminated polydioxanone monolauryl ether (molecular weight 3,500) were added to the dry reactor ), add 305 ml dimethyl sulfoxide, then add 0.031 g N,N'-diisopropylcarbodiimide, under inert atmosphere, stir and react at 27°C for 4 days, terminate the reaction, filter, dialyze, dry , get the target object;

[0027] 2) Synthesis of polyethylene glycol-polydioxanone block copolymer

[0028] Add 3 grams of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 6000) and 9 grams of carboxyl-terminated polydioxanone monododecyl ether (molecular weight: 3500) in the dry reactor, add 155 ml dimethyl sulfoxide, then add 0.08 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed, and dried to obtain the target product;

[0029] 3)...

Embodiment 3

[0033] 1) Synthesis of Polypeptide-Polydioxanone Block Copolymer

[0034] 16.5 g of poly(r-methyl-L-glutamate) (molecular weight 90,000) and 7 g of carboxy-terminated polydioxanone monolauryl ether (molecular weight 4,000) were added to the dry reactor ), add 310 ml dimethyl sulfoxide, then add 0.046 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, and stir the reaction at 30°C for 3 days under an inert atmosphere to terminate the reaction , by filtering, dialysis and drying, the target object is obtained;

[0035] 2) Synthesis of polyethylene glycol-polydioxanone block copolymer

[0036] Add 3.1 grams of amino-terminated polyethylene glycol monomethyl ether (molecular weight is 7000) and 9.2 grams of carboxy-terminated polydioxanone monododecyl ether (molecular weight is 4000) in the dry reactor, add 158 ml dimethyl sulfoxide, then add 0.141 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir the reaction at 35°C for 2 days, then terminate ...

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Abstract

The invention discloses a method for improving the hydrophilia and flexibility of a polypeptide membrane through polydioxanone and polyethylene glycol. The method includes the following steps that firstly, carboxyl-terminated polydioxanone monododecyl ether, a solution, a condensing agent and a polypeptide homopolymer are added in a drying reactor for reaction for 3-4 days, and a polypeptide-polydioxanone segmented copolymer is obtained; secondly, carboxyl-terminated polydioxanone monododecyl ether carboxyl, a solution, a condensing agent and amidogen-terminated ethylene glycol monomethyl ether are added in the drying reactor for reaction for 2-3 days, and a polyethylene glycol-polydioxanone segmented copolymer is obtained; thirdly, the polypeptide-polydioxanone segmented copolymer, the polyethylene glycol-polydioxanone segmented copolymer and a solvent are added in the drying reactor to be mixed for 40-50 minutes, then tape casting is used for forming the membrane, drying is conducted, and the target object of the method is obtained. The method is simple in preparation technology, and the hydrophilia and flexibility of the obtained modified membrane are greatly improved.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity and flexibility of a polypeptide film with polydioxanone and polyethylene glycol, and belongs to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide film is relatively stiff and lacks hydrophilicity, which limits its application. Polydioxanone has better biocompatibility and biodegradability, and is relatively soft. Polyethylene glycol has good biocompatibility and biodegradability, is relatively soft and has good hydrophilicity. First, the polydioxanone segment is introduced into the polypeptide segment and the polyethylene glycol segment to form a polypeptide-polydioxanone block copolymer and a polyethylene glycol-polydioxanone block copolymer. Hexanone block copolymer, and then mix the two copolymers to ...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08L87/00C08G81/00C08G69/48
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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