67 results about "Pandrug resistant bacteria" patented technology

The present invention provides a therapeutic method for treating biological diseases that includes the administration of an effective amount of a suitable antibiotic agent, antifungal agent or antiviral agent in conjunction with an A_2A adenosine receptor agonist. If no anti-pathogenic agent is known the A_2A agonist can be used alone to reduce inflammation, as may occur during infection with antibiotic resistant bacteria, or certain viruses such as those that cause SARS or Ebola. Optionally, the method includes administration of a type IV PDE inhibitor.

The present invention relates to compositions and methods using an isolated chimeric molecule, wherein the isolated chimeric molecule comprises an antibody, one or more albumin motifs, optional peptide linkers, and two or more antibiotics or cytotoxic drug molecules conjugated to the unpaired cysteine residues, optionally through linkers. In one embodiment, each of the said albumin motifs in the isolated chimeric molecule contains 2 or more unpaired cysteine residues. In another embodiment, the said antibody in the isolated chimeric molecule targets antigens on cancer cells or drug-resistant bacteria. In another embodiment, the cancer cells have upregulated macropinocytosis. In another embodiment, the cancer cells contain one or more mutations in their RAS family genes. The compositions of the invention are used to treat drug-resistant bacterial infections and cancers, preferably the ones with upregulated macropinocytosis, and the ones containing one or more mutations in their RAS family genes.

The invention relates to the field of biomedicine and in particular relates to an antibacterial polypeptide. Part of active amino acids of the antibacterial polypeptide of Cathelicidin family is mutated based on the antibacterial polypeptide of Cathelicidin family, and then the antibacterial polypeptide with high inhibitory activity to penicilin-resistant bacterium is obtained by solid phase chemical synthesis. The result of pharmacodynamic tests shows that the antibacterial polypeptide provided by the invention has good in vitro antibacterial activity and is applicable to treating diseases about drug-resistant bacterial infection.

The invention discloses antibacterial peptides and application of the antibacterial peptides to preparation of a medicament resisting drug-resistant bacteria. The antibacterial peptides consist of 21 amino acids, wherein the amino acid sequence is shown as SEQIDNO.1. The in-vivo and in-vitro research shows that six kinds of antibacterial peptides have a strong inhibiting and killing action for the mostly clinically-separated drug-resistant bacteria and can remarkably reduce the mortality of a septicemia model caused by the drug-resistant bacteria; and a hemolytic test and an acute local stimulus test results show that six kinds of derivates have no hemolytic test or acute toxic stimulus reaction when the concentration is 2.5mg/mL.

The invention relates to a double-chain small molecule interference nucleic acid for inhibiting and killing various drug tolerance bacteria using methicillin-resistant staphylococcus aurous as represents. The siNA of the invention is a double-chain molecule with 19 base pairs. A sense strand and a antisense strand respectively have two overhanging bases dT at 5' terminals, the GC content is 40-55; the aimed target sequence is selected from the genes relative with the vital movements of copy, transcription and translation in the staphylococcus aurous genome and an mecA gene correlative with the drug tolerance; said target sequence is preserved in 900f staphylococcus aurous; said target sequence is in a conservative sequence area in more than 900f staphylococcus aurous with distinct source with all the gene sequences in the human genome; the target sequence of the said siNA double-chain molecule is selected from SEQ ID NO. 1-325, the sense strand is a corresponding DNA or RNA sequence with the target sequence and the antisense strand is a corresponding RNA or DNA with the sense strand according to the complementary base law.

The invention discloses a 3,5-dimethoxystilbene derivative, a preparation method and an application thereof, in particular relating to the synthesis of the 3,5-dimethoxystilbene derivative as shown in structural formula (1) and anti-drug resistant bacterial activity thereof. The preparation method comprises the following steps: firstly mixing 3,5-dimethoxybenzyl bromide with triethyl phosphate to obtain 3,5-dimethoxybenzyl phosphonate; and then carrying out Wittig-Honner reaction to obtain the 3,5-dimethoxystilbene derivative. The preparation method has the advantages of high yield, simple and convenient operation, low cost, good industrialization prospect and the like. A bacterial inhibiting test result shows that the synthesized 3,5-dimethoxystilbene derivative has obvious inhibition activity on drug resistant bacteria and is of great significance on research and development of a novel anti-drug resistant bacterial drug.

The invention provides a Portunus trituperculatus antibacterial peptide gene and a cloning method thereof. The Portunus trituperculatus crustin antibacterial peptide gene cDNA is 565nt except poly A, and contains 5' non-coding region (5' UTR) of 75nt, a reading frame of 330nt, and 3' non-coding region (3' UTR) of 160nt, wherein the sequence number of GenBank is FJ467931. The method successfully clones complete sequence of Portunus trituperculatus crustin cDNA, can construct pronucleus or eucaryon gene engineering strain through a gene engineering mode, efficiently express recombinant protein with physiological activity, and can be produced in scale. As a feed immunity additive, the gene can replace certain antibiotics in the traditional feed for seaculture industry, thereby realizing green culture, reducing and even eliminating accumulation of the antibiotics in aquatic products, and improving quality of the aquatic products; the gene can also be used as an effective substitute of certain drug resistance antibiotics for the medicine of preventing and treating drug resistance bacteria in seaculture.

The invention relates to polypeptide capable of inhibiting and killing bacteria, and in particular relates to multiple medicine-resisting bacteria. The polypeptide is remarkable in effect of killing or inhibiting methicillin-resistant staphylococcus epidermidis, klebsiella pneumoniae, baumanii and/or escherichia coli. The invention further relates to a composition with the defined polypeptide, and an application of the defined polypeptide and the composition thereof in preparation of medicines and in killing or inhibiting of multiple in-vitro medicine-resisting bacteria.

The invention relates to the technical field of polypeptide drugs in biochemistry, in particular to a polypeptide and application thereof. An unnatural amino acid is introduced according to an antimicrobial peptide Cbf-14 to obtain the polypeptide Cbf-14-2 having the high inhibiting activity on drug-resistant bacteria. An amino acid sequence of the antibacterial polypeptide is shown as SEQ ID: NO:1. An in-vitro antibacterial activity research shows that the polypeptide Cbf-14-2 has a more remarkable killing effect on clinic drug-resistant bacteria compared with a parent peptide Cbf-14. An in-vivo bacteremia model research shows that the polypeptide Cbf-14-2 can remarkably improve the survival rate of a rat suffering from bacteremia, the weight of the rat suffering from the bacteremia is protected, the bacterium concentration of the polypeptide in blood is reduced, and meanwhile the polypeptide has the very good treating effect on lung tissue infection inflammation caused by drug-resistant strains. The polypeptide Cbf-14-2 has very small toxicity to mammalian cells.

The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

The invention relates to a preparation method of a modified peptide. The preparation method comprises the following steps: covalently coupling a polypeptide with a photosensitizer through three glycines (GGG), wherein the conjugate has a relatively strong antibacterial effect (the antibacterial rate) of 50%, and can effectively kill most microorganisms including drug-resistant bacteria under illumination, and the sterilization rate reaches 99.999%. The conjugate has the effects of preventing infection and promoting healing on cut wounds of mice. The compound is simple in preparation method, relatively high in yield and convenient to store, can be used for preparing products such as antibacterial reagents and antibacterial drugs, and has a good application prospect in the fields of clinicaltreatment of local infection and wound dressing.

The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract

The invention relates to the technical field of medicine and discloses an antibacterial application of a Dryopteris fragrans phloroglucinol compound flavaspidic acid BB. The invention provides the flavaspidic acid BB obtained by the chemical synthesis method. The flavaspidic acid BB has good antibacterial effects, effectively fills in the application deficiency of the antibacterial natural compound and provides an effective antibacterial solution for drug-resistant bacteria. The experimental results show that the compound has a strong antibacterial effect and good curative effects especially on drug-resistant bacteria.

The invention belongs to the technical field of antibacterial medicines, and relates to a 1-substituted benzoyl-4-fatty acylsemicarbazide derivative, a preparation method thereof, and a use thereof as an antibacterial medicine. The compound is represented by formula (I); and in the formula (I), R1 is selected from hydrogen, a hydroxyl group, a C1-C8 alkyl group, a C1-C8 alkoxy group, an arylmethoxy group and a halogenated arylmethoxy group, R2 is selected from hydrogen, a C1-C8 alkyl group and a halogenated C1-C8 alkyl group, and X is selected from sulfur and oxygen. The 1-substituted benzoyl-4-fatty acylsemicarbazide derivative of the present invention has a strong inhibition effect on Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and vancomycin-resistant enterococci (VRE), and can be used for preparing novel drug-resistant bacteria medicines.

The invention belongs to the technical field of antibacterial agents, and relates to a 1-substituted benzoyl-4-fatty acyl semicarbazide derivative, a preparation method and application thereof as an antibacterial agent. The compound is shown in a formula (I), wherein R1 is selected from hydrogen, hydroxyl, C1-C3 alkyls, C1-C8 alkoxyls, C3-C6 cycloalkyl oxyls, non-substitute or halogenated phenylsC1-C3 alkoxyls, phenyls, C1-C3 alkylbenzene, halogeno benzene, and the substitution site of R1 is selected from ortho-position or meta-position or para-position; R2 is selected from non-substitute orhalogenated C1-C8 alkyls, non-substitute or halogenated C3-C6 naphthenic bases and non-substitute or halogenated phenyl C1-C3 alkyls; X is selected from sulfur or oxygen. The 1-substituted benzoyl-4-fatty acyl semicarbazide derivative has the high inhibiting effect on drug-resistance bacteria including gram-positive bacteria, in particular to methicillin-resistant staphylococcus aureus (MRSA), methicillin-resistant staphylococcus epidermidis (MRSE) and vancomycin resistant enterococcus (VRE), and can be used for preparing novel drug resistance bacterium drugs. The formula is shown in the description.

The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is present in an amount equal to or less than about 21.5 mg/5 mL, and a method of treating bacterial infections by providing between about one to about fourteen dosage days of the composition. Also disclosed are methods of treating a patient comprising administering amoxicillin and clavulanate potassium to the patient in dosages of at least about 80 mg/kg/day of the amoxicillin and from about 1.66 mg/kg/day to about 2.84 mg/kg/day of the clavulanate potassium. The methods are useful for treating pediatric otitis media, treating a drug resistant bacterial infection, or treating beta-lactamase producing Haemophilus influenzae or Moraxella catarrhalis in a patient under 24 months of age.

The invention belongs to the technical field of nano-material preparation and bacterial infection resistance, and relates to a glucose oxidase and hemoglobin loaded nano-reactor and a preparation method and an application thereof, the structure of the nano-reactor is a zeolite imidazate skeleton structure simultaneously loading glucose oxidase and hemoglobin, and the nano-reactor can be applied to bacterial infection resistance, and particularly, bacterial infection of wounds of diabetics can be controlled, and wound healing is promoted; the nano-reactor has good biocompatibility and environmental friendliness, is more remarkable in antibacterial effect, can achieve a good antibacterial effect without adding exogenous hydrogen peroxide, has a remarkable bactericidal effect on methicillin-resistant staphylococcus aureus and escherichia coli producing extended-spectrum beta-lactamase, and can efficiently promote the wound healing caused by multi-drug-resistant bacterial infection of the diabetics, and the market prospect is extremely wide.