20 results about "Pandrug resistant bacteria" patented technology

The invention provides a bionic antibacterial peptide, a pharmaceutical composition, application of the bionic antibacterial peptide in preparation of antibacterial drugs and a design method of the bionic antibacterial peptide. A plurality of compounds are used for carrying out N-terminal modification on a polypeptide sequence consisting of 20 natural amino acids, so that a novel antibacterial peptide with a bionic function is generated, and the designed bionic antibacterial peptide is screened by adopting a method based on deep learning and experimental interaction. Compared with traditional drug screening, consumed time, manpower, material resources and financial resources are greatly reduced, the designed novel bionic antibacterial peptide has good biocompatibility, a functional group modified at the N end of the novel bionic antibacterial peptide can activate the self-assembly activity of polypeptide and help the polypeptide target a bacterial membrane, bacterial drug resistance is not likely to be caused, and the novel bionic antibacterial peptide has good application prospects. The drug-resistant bacteria can be effectively killed, the sterilization speed is higher, and potential and wide application prospects are achieved in clinical treatment of bacteria and drug-resistant bacteria infection diseases.

There is provided a method of at least partially inhibiting the function of Klebsiella pneumoniae carbapenemase-2 (KPC-2) or a variant thereof, the method comprising reacting said KPC-2 with a compound selected from the group consisting of 5-chloro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-chloro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-chloro-1, 3-dihydro-1-hydroxy-2, 1- The present invention relates to a method for contacting a beta-lactam antibiotic-resistant bacterium with a benzoxaborolane selected from the group consisting of 1, 1-benzoxaborolane and mixtures thereof, which can be used to treat an infection with a beta-lactam antibiotic-resistant bacterium in a subject.

The present application provides a bionic antibacterial peptide, a pharmaceutical composition and its application in the preparation of antibacterial drugs, as well as a design method of the bionic antibacterial peptide. A variety of compounds are used to modify the N-terminus of a polypeptide sequence composed of 20 natural amino acids, thereby generating a novel antibacterial peptide with bionic functions. Moreover, a method based on the interaction between deep learning and experiments is adopted to screen the designed bionic antibacterial peptide. The time, manpower, material resources and financial resources consumed are greatly reduced compared with traditional drug screening. In addition, the designed novel bionic antibacterial peptide has good biocompatibility. The functional groups modified at the N-terminus can activate the self-assembly activity of the polypeptide and help the polypeptide target the bacterial membrane, which is not easy to cause bacterial drug resistance, can effectively kill drug-resistant bacteria, has a faster bactericidal speed, and has potential and broad application prospects in the treatment of clinical bacterial and drug-resistant bacterial infectious diseases.

The present invention belongs to the technical field of material preparation and application, and discloses a nano-spherical porous copper porphyrin, a preparation method thereof and uses thereof. The present invention uses gallium black phosphorus as a template to drive the coordination of 5,10,15,20-tetrakis(4-aminophenyl)porphyrin and terephthaloyl chloride to induce the directional formation of nano-porous copper porphyrin with gallium black phosphorus as the core; the nano-porous copper porphyrin material prepared by the present invention is a porous sphere, and has excellent photodynamic, chemical kinetic and photothermal properties. Under dark conditions, it has the characteristics of catalase and catalyzes the production of hydroxyl radicals from hydrogen peroxide; under red light irradiation, it can continuously generate singlet oxygen; under near-infrared light irradiation, it has good photothermal properties, and this material is expected to be applied to the treatment of drug-resistant bacterial infections.

Compositions and methods are provided for treating bacterial infections, including those that are challenging to treat by conventional medications, such as hospital acquired bacterial pneumonia (HABP), ventilator associated bacterial pneumonia (VABP), and bacteremia, caused by carbapenem-resistant bacteria such as Acinetobacter baumannii and Pseudomonas aeruginosa.

The invention discloses a vibrio parahaemolyticus hfq gene deleted strain as well as a construction method and application thereof. The invention provides a deletion strain, a construction method of the deletion strain and application of the deletion strain in construction of an enrofloxacin drug resistance model. The invention finds that after the hfq gene is deleted, the drug resistance to the enrofloxacin is obviously increased. It is further proved that the vibrio parahaemolyticus ATCC33846 delta hfq deletion strain enhances the drug resistance to enrofloxacin by improving the excretion of rhodamine 6G. The vibrio parahaemolyticus deletion strain is constructed by utilizing high efficiency and accuracy of homologous recombination, and the important effect of the hfq gene on the drug resistance of the vibrio parahaemolyticus is proved by comparing the drug resistance of the deletion strain and a wild strain on enrofloxacin. The compound can be used for developing a new therapy for drug-resistant bacteria or improving an existing antibacterial strategy.

Provided in this disclosure are methods of treating a bacterial infection comprising administering a formulation comprising an antimicrobial peptide described herein when administered to a subject. Further provided herein are methods of treating a bacterial infection wherein the bacterial infection comprises a bacterium with a mutation in a gene resulting in antibiotic resistance.

The invention provides a pharmaceutical composition aiming at mcr positive drug-resistant bacteria and application of the pharmaceutical composition, and belongs to the technical field of biomedicine. The composition is composed of patchouli alcohol and polymyxin B or polymyxin E, and the antibacterial effect on mcr positive drug-resistant bacteria is remarkably enhanced. Experimental results show that when patchouli alcohol and polymyxin B or E are combined for use, the minimum inhibitory concentration (MIC) of polymyxin can be remarkably reduced, and the FIC is less than 0.5, so that the patchouli alcohol and the polymyxin B or E have a synergistic effect. In addition, a cytotoxicity experiment shows that patchouli alcohol has no obvious toxicity to normal cells in a certain concentration range and has relatively high safety. The composition can be used as a synergistic enhancer of polymyxin, can effectively cope with mcr positive drug-resistant bacterial infection, provides a safe and efficient new way for treatment of drug-resistant bacterial infection, and is helpful for delaying the progress of antibiotic drug resistance crisis.

The invention discloses a hemicyanine fluorescent molecule for detecting bacterial infection and bacterial metabolism as well as preparation and application thereof, relates to a hemicyanine-based molecule as well as a preparation method and application thereof, and belongs to the field of detection. The compound can specifically detect bacteria, even drug-resistant bacteria and the fatty acid beta-oxidation physiological process of the bacteria. Through the enhancement of the fluorescence signal, the bacteria type or metabolism condition can be visually judged. By introducing carbon chains with different lengths, the sensitivity of the probe to bacteria is improved, and the accuracy of bacteria detection is promoted. The compound AC5 realizes the detection of 100 mu M of drug resistance of pseudomonas aeruginosa / ceftazidime. The probe provides a promising novel method for early detection of in-vivo deep bacterial infection and research of bacterial oxidative metabolism. Furthermore, a mannose part is introduced, so that the compound D1 shows targeting on the cellular level, and the compound D1 can be used for researching the oxidative metabolism condition of macrophages. # imgabs0 #

A compound and a pharmaceutical composition have an inhibitory activity on a drug efflux pump of drug-resistant bacteria, and can restore the antibacterial activity of other agents in a case of being used in combination with other drugs. A compound represented by General Formula [1], or a salt thereof, and a pharmaceutical composition containing the compound or the salt are provided. In Formula [1], each symbol is as described in the specification.

Provided in this disclosure are methods of treating a bacterial infection comprising administering a formulation comprising an antimicrobial peptide described herein when administered to a subject. Further provided herein are methods of treating a bacterial infection wherein the bacterial infection comprises a bacterium with a mutation in a gene resulting in antibiotic resistance.

A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed. The 3H-imidazo[4,5-C]pyridine pleuromutilin onium salt derivatives exhibit good water solubility and excellent activity against resistant mycoplasma, in vivo and in vitro antibacterial activity, and are of great value in the development of anti-resistant bacteria drugs and have good medical application prospects.

The present invention belongs to the technical field of anti-infective drugs, and relates to the preparation method of 1,4-dicarbonyl thiosemicarbazide compounds and their use as anti-infective drugs. The compound is as shown in formula (I), and A can be selected from a benzene ring, a halogenated benzene, a pyridine and a pyrimidine; wherein R1 is selected from unsubstituted or halogenated C1-C6 alkyl, C3-C6 cycloalkyl; R2 is selected from C4-C8 alkylbenzene, C3-C8 cycloalkylbenzene, C3-C8 cycloalkyl, C1-C8 alkyl-substituted C3-C8 cycloalkyl, and the substitution position of R2 is selected from ortho-position, meta-position or para-position. The 1,4-dicarbonyl thiourea compounds of the present invention have a strong inhibitory effect on Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and vancomycin-resistant Enterococcus (VRE) resistant bacteria, and can be used to prepare anti-resistant bacteria drugs.

The invention provides a cyclic bacteriocin FlexusinA with antibacterial activity, the amino acid sequence of the cyclic bacteriocin FlexusinA is an amino acid sequence which is obtained by substitution and / or deletion and / or addition of one or more amino acid residues on the amino acid sequence as shown in SEQ ID NO: 1 and has the same function, and the sequence similarity of the cyclic bacteriocin FlexusinA is greater than or equal to 70%; a nucleotide sequence for synthesizing the cyclic bacteriocin FlexusinA is shown as a sequence table SEQ ID NO: 2, and the cyclic bacteriocin FlexusinA is composed of 201 nucleotides in total; the propeptide amino acid sequence of the cyclic bacteriocin Flexusin A before cyclization is as shown in SEQ ID NO: 3 in a sequence table, and the number of amino acids is 66. The cyclic bacteriocin Flexusin A has bacteriostatic activity on a part of gram-positive pathogenic bacteria such as staphylococcus aureus, methicillin-resistant staphylococcus aureus, listeria monocytogenes, enterococcus faecalis, streptococcus agalactiae and bacillus cereus, and particularly has inhibitory activity on drug-resistant bacteria.

The invention discloses a preparation method and application of an antibacterial peptide hydrogel dressing with good drug resistance, and relates to the technical field of functional materials. Comprising antibacterial peptide, an initiator, a sodium alginate matrix, a reaction aid, a reaction activator and the like. The preparation method has the beneficial effects that the antibacterial peptide is screened, and the prepared antibacterial peptide is added into a sodium alginate matrix, so that rapid gelation under a normal-temperature condition can be realized; the gel has the characteristics of good stability, short coagulation time, long sterilization time, excellent drug resistance and the like, has good adhesive force and lasting antibacterial effect, can realize efficient sterilization, realizes the dual effects of efficient antibacterial and difficult generation of drug resistance, and solves the problem of drug-resistant bacteria in the process of treating skin bacterial infection. The polypeptide has potential application value in the aspect of treating bacterial infectious diseases.

Antimicrobial peptides (AMPs) exhibiting broad spectrum antimicrobial activity are described. Such peptides are useful in treating or preventing infections and other conditions, and are of special interest for treating antibiotic-resistant bacterial pathogens, viruses, fungi, and other pathogens, or for anti-cancer applications. Treatment or prevention of infection in humans or animals is described, such as for use in poultry and other livestock applications. Uses and methods are described for disinfecting or prevention of growth of microbes on a surface, a material, or in an environment, such as for environmental remediation.

The present disclosure relates to methods for treating multidrug resistant bacterial infectious conditions. In particular, the disclosure provides BTN3A-activating antibodies, and their use in the treatment of multidrug resistant bacterial infectious disorders, such as disorders caused by multidrug resistant Mycobacterium tuberculosis infection, in human subjects in need thereof.

The application belongs to the technical field of microorganism detection, and particularly relates to a primer set for detecting drug-resistant bacteria and application thereof, wherein the primer set comprises one upstream primer, one downstream primer and one probe; the sequence of the upstream primer is shown as SEQ ID NO. 1; the sequence of the downstream primer is shown as SEQ ID NO. 2; and the sequence of the probe is shown as SEQ ID NO. 6. Based on the primer set, the application establishes a method for detecting azolane ketone drug-resistant gene optrA The fluorescent RAA detection method can complete amplification within 21 min under isothermal conditions at 37 DEG C, the primer set has high specificity, and the RAA amplification result can be observed by ultraviolet analysis instrument with naked eyes, so that the possibility of rapid detection in basic areas is provided.

The invention provides a preparation method and antibacterial application of a heterostructure BiOCl (at) Ag nano-catalyst, and provides a reliable path for effectively weakening negative effects caused by drug-resistant bacteria. The prepared BiOCl (at) Ag catalyst has an extended light absorption characteristic, and can generate a remarkable photo-thermal effect under the condition of near-infrared band light irradiation, so that an efficient photo-thermal antibacterial effect is realized. Meanwhile, high matching is achieved through a good heterogeneous interface in the BiOCl (at) Ag catalyst, and effective separation of photon-generated carriers after light absorption is greatly enhanced through Ag particles with the surface plasmon resonance effect. The process further promotes the generation of antibacterial active oxygen free radical substances, accelerates the efficient removal of harmful bacteria, and forms a strong synergistic antibacterial ability. The heterojunction nano-catalyst BiOCl (at) Ag provided by the invention provides a technical means with great potential for broad-spectrum antibacterial application by virtue of various action ways such as Ag ion release, plasma resonance photothermal effect, photocatalytic active substance generation and the like.

Provided are a peptide derived from an antimicrobial peptide Thanatin and a medical use thereof. The antimicrobial peptide demonstrates different antimicrobial activities on various clinical multi-drug-resistant bacteria without any hemolytic activity and cytotoxicity and can be used for preparing a drug for resisting infection caused by multi-drug-resistant bacteria. Peptides having such structures are used alone or in combination as an auxiliary material for other drugs or as an additive for food, cosmetics, and fodders, so that infection caused by drug-resistant bacteria can be treated without inducing generation of drug-resistant bacteria.