Polypeptide Cbf-14 resisting infection of drug-resistant bacteria and application thereof

A technology of anti-drug-resistant bacteria and antibacterial peptides, applied in the field of biomedicine, can solve the problems of poor proteasome stability, high toxicity of antimicrobial peptides, and high production costs of antimicrobial peptides
CN103435686AActive Publication Date: 2013-12-11NANJING YINGHAIYUE BIOLOGICAL SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING YINGHAIYUE BIOLOGICAL SCI & TECH
Publication Date
2013-12-11

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Abstract

The invention relates to the field of biomedicine and in particular relates to an antibacterial polypeptide. Part of active amino acids of the antibacterial polypeptide of Cathelicidin family is mutated based on the antibacterial polypeptide of Cathelicidin family, and then the antibacterial polypeptide with high inhibitory activity to penicilin-resistant bacterium is obtained by solid phase chemical synthesis. The result of pharmacodynamic tests shows that the antibacterial polypeptide provided by the invention has good in vitro antibacterial activity and is applicable to treating diseases about drug-resistant bacterial infection.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to an antibacterial polypeptide and its application. The antibacterial polypeptide of the invention has the application of resisting drug-resistant bacterial infection. Background technique

[0002] With the extensive use of antibiotics, especially non-indication use, inappropriate selection of backup antibacterial drugs, overtreatment and frequent dressing changes, the rate of bacterial drug resistance is getting higher and higher, and the degree of drug resistance is becoming more and more serious. The existence of spontaneous drug-resistant mutations and the continuous effect of antibiotic selection pressure, as well as the environmental adaptability of pathogenic bacteria and the evolutionary drive of ecological changes in the human microenvironment, are the basis for the emergence of clinically drug-resistant and multidrug-resistant bacteria. The emergence and development o...

Claims

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