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Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle

A microfluidic chip, hydroxyapatite technology, applied in nanotechnology, chemical instruments and methods, phosphorus compounds, etc.

Inactive Publication Date: 2012-10-24
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the co-precipitation method is favored by people for its advantages of simple equipment, low cost, and easy operation. However, the traditional co-precipitation method is still limited to the preparation of HAp materials with relatively simple functions. There are still great limitations in online monitoring and regulation of material synthesis

Method used

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  • Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle
  • Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle
  • Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Droplet fusion and rapid mixing under different disperse phase flow rates using figure 1 The structure of the chip shown, see the actual figure 2 . The syringe pump continuously perfuses the reservoir A with mineral oil at a flow rate of 800 nl / min, and continuously perfuses the reservoir B (1) with deionized water at a flow rate of 500 nl / min. The flow rate ranges from 150 nl / min to 1000 nl / min. The inner pair of reservoir B (2) was continuously perfused with a 20 mg / ml amaranth dye solution. Water-in-oil droplets (deionized water / mineral oil) are continuously formed at the first-stage T-shaped channel 1, and driven by mineral oil to flow along the channel through the second-stage T-shaped channel 2 to meet the amaranth solution , through the three processes of collision, oil discharge, and oil film rupture, the amaranth solution enters the droplet and realizes fusion, such as Figure 4 shown. Keeping the flow rate of the continuous phase of mineral oil and the d...

Embodiment 2

[0035] Synthesis and electron microscope characterization of acicular hydroxyapatite nanoparticles. Diamine hydrogen phosphate was dissolved in deionized water to prepare a 0.06 mol / L solution. The solution contained 0.1 mol / l ammonia water to control the droplets after fusion. The pH value of the phase solution (10~11); calcium nitrate was dissolved in deionized water to prepare a 0.1mol / L solution. Use a syringe pump to continuously perfuse mineral oil to reservoir A at a flow rate of 800 nl / min, and to continuously perfuse 0.06 mol / L aqueous ammonia solution of diamine hydrogen phosphate to reservoir B (1), and to perfuse the reservoir at a flow rate of 500 nl / min. Pool B (2) was continuously perfused with 0.1 mol / L calcium nitrate solution. Droplets of phosphorus-in-oil precursor (phosphorus precursor / mineral oil) are continuously formed at the first-stage T-shaped channel 1, and driven by mineral oil to flow along the channel through the second-stage T-shaped channel 2 an...

Embodiment 3

[0037] Droplet fusion and rapid mixing of different dyes as dispersed phases, using figure 1 The chip with the structure shown is shown in figure 2 . The syringe pump continuously perfused mineral oil into reservoir A at a flow rate of 800 nl / min, continuously perfused 20 mg / ml amaranth dye solution into reservoir B (1) at a flow rate of 500 nl / min, and Reservoir B (2) was continuously perfused with 20 mg / ml bromocresol blue dye solution. Droplets of the oil-in-amaranth solution (maranth / mineral oil) are continuously formed at the first-stage T-shaped channel 1, and the droplets flow along the channel through the second-stage T-shaped channel 2 under the driving of the mineral oil. When bromocresol blue solutions meet, through three processes of collision, oil discharge and oil film rupture, the bromocresol blue solution enters the droplets to achieve fusion. It can be seen from the observation that when the droplet moves in the curved channel, the bromocresol blue dye mo...

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Abstract

The invention provides a microfluidic chip based method for synthesizing needle-like hydroxyapatite (HAp) nanoparticles. The method employs monodisperse microfluidic droplet as a micro reactor, and utilizes a microfluidic chip droplet fusion as a core technology to realize HAp nanoparticle synthesis on a chip. The method has the following advantages: the droplet has small volume, and chaotic mixing has a rapid mass transfer speed; droplet is used as the micro reactor, and a product is output by continuous phase to diminish adsorption on passageway wall and agglomeration of nanoparticles; a PDMS chip is transparent, and easy for online real-time monitoring of material formation and control; and the design of the chip is simple, and easy for construction of multiple parallel reaction channels for high-throughput synthesis, so as to improve the yield of product.

Description

technical field [0001] The invention relates to a technology for synthesizing needle-like hydroxyapatite nanoparticles, and in particular provides a method for synthesizing needle-like hydroxyapatite nanoparticles based on a microfluidic chip. Background technique [0002] Hydroxyapatite (HAp for short) is a weakly alkaline calcium phosphate bioceramic material that is insoluble in water. It is the main component of natural bone, has good biocompatibility and bioactivity, can induce the formation of new bone and provide a scaffold for it; it can directly form a good osseointegration with bone tissue, and is an ideal hard tissue Replacement material. Due to its unique biological activity and compatibility, HAp has become a research hotspot in biomedical materials. The purpose of the research is to ensure that the material has a uniform morphology, narrow particle size distribution, good monodispersity and large surface area. Among them, uniform morphology and controllable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 秦建华刘开颖
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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