Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing injectable hydroxyapatite nano-composite supramolecular hydrogel

A supramolecular hydrogel, hydroxyapatite technology, applied in the fields of biomedical materials and nano-functional materials, can solve the problems of unbearable, low strength and brittleness of hydroxyapatite nanoparticles, and achieve a safe preparation process. Effect

Inactive Publication Date: 2009-10-14
WUHAN UNIV OF TECH
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydroxyapatite nanoparticles have low strength and high brittleness. When processed to a thickness of 2mm, they will break and cannot bear the general external force during and after surgery.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing injectable hydroxyapatite nano-composite supramolecular hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preparation method for injectable hydroxyapatite nanocomposite supramolecular hydrogel, comprising the steps of:

[0016] 1) Take polyoxyethylene-polyoxypropylene-polyoxyethylene triblock polymer [Pluronic, Aldrich; molecular weight is 14600, the mass content of polyoxyethylene is 82.5%] 50mg, add the hydroxyapatite that particle size is 10nm Add 1 mg of stone nanoparticles, add 5 mL of water, and disperse ultrasonically (ultrasonic conditions: power 60w, frequency 20kHz, ultrasonic time 3min), to obtain a suspension;

[0017] 2) Take 400 mg of α-cyclodextrin (α-CD), add 5 mL of water, and prepare an aqueous solution of α-cyclodextrin with a mass concentration of 80 mg / mL;

[0018] 3) Mix the suspension obtained in step 1) with the α-cyclodextrin aqueous solution obtained in step 2) to obtain a mixed aqueous solution (the mass concentration of hydroxyapatite nanoparticles in the mixed aqueous solution is 0.1 mg / mL, Pluronic triblock The concentration of the polymer i...

Embodiment 2

[0021] 1 mg of hydroxyapatite nanoparticles with a particle size of 10 nm in Example 1 was replaced with 5 mg of hydroxyapatite nanoparticles with a particle size of 200 nm. All the other steps are the same as in Example 1.

Embodiment 3

[0023] 10 mg of hydroxyapatite nanoparticles with a particle size of 300 nm was used instead of 1 mg of hydroxyapatite nanoparticles with a particle size of 10 nm in Example 1. All the other steps are the same as Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a method for preparing a hydroxyapatite nano-composite supramolecular hydrogel with biocompatibility. A method for preparing an injectable hydroxyapatite nano-composite supramolecular hydrogel is characterized in that the method comprises the following steps of 1) selecting, mixing and ultrasonic dispersing a polyethylene oxide-poly(propylene oxide)-polyethylene oxide triblock polymer, a hydroxyapatite nanoparticle and water with the ratio of 10-200mg:0.2-100mg:1mL, thus obtaining the suspension of the hydroxyapatite nanoparticle; 2) according to the polyethylene oxide-poly(propylene oxide)-polyethylene oxide triblock polymer, the hydroxyapatite nanoparticle, an Alpha-cyclodextrin and water with the ratio of 10-200mg:0.2-100mg:80-400mg:1mL and selecting Alpha-cyclodextrin and water to prepare the water solution of Alpha-cyclodextrin; and 3) mixing, ultrasonic dispersing and standing the suspension obtained in the step 1) and the Alpha-cyclodextrin water solution obtained in the step 2), thus obtaining the injectable hydroxyapatite nano-composite supramolecular hydrogel. The preparation process is safe, simple and effective.

Description

technical field [0001] The invention belongs to the field of nano functional materials and also belongs to the field of biomedical materials; in particular, it relates to a preparation method of hydroxyapatite nanocomposite supramolecular hydrogel with biocompatibility. Background technique [0002] Hydroxyapatite is the main inorganic component in human bones. It is a weakly alkaline calcium phosphate salt slightly soluble in water. Its chemical formula is [Ca 10 (PO 4 ) 6 (OH) 2 , hydroxyapatite, HAP], has good biocompatibility, bioactivity and good osteogenesis ability and is widely used in bone tissue engineering materials. However, hydroxyapatite nanoparticles have low strength and high brittleness. When processed to a thickness of 2mm, they will break and cannot bear the general external force during and after surgery. Smart supramolecular hydrogels have been widely used in drug delivery and controlled release, biodetection and sensing, biomedicine, and tissue engi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/52A61L27/16A61L27/12A61L27/20
Inventor 黄进范红蕾唐超余家会张晓兰杨光正徐海星
Owner WUHAN UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com