Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mesoporous hydroxyapatite nonoparticles prepared by microwave-ultrasonic method, and application thereof

A mesoporous hydroxyapatite and nanoparticle technology, applied in the field of materials science, can solve the problem of serious particle agglomeration

Inactive Publication Date: 2012-12-19
EAST CHINA UNIV OF SCI & TECH
View PDF1 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These processes all use emulsifiers or templates, and the synthetic particle agglomeration is very serious

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mesoporous hydroxyapatite nonoparticles prepared by microwave-ultrasonic method, and application thereof
  • Mesoporous hydroxyapatite nonoparticles prepared by microwave-ultrasonic method, and application thereof
  • Mesoporous hydroxyapatite nonoparticles prepared by microwave-ultrasonic method, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] In one embodiment of the present invention, a kind of preparation method of mesoporous hydroxyapatite nanoparticles is provided, comprising the following steps:

[0058] (a) Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 aqueous solution, and using ammonia to (NH 4 ) 2 HPO 4 The pH of the aqueous solution is adjusted to 9-12;

[0059] (b) the above (NH 4 ) 2 HPO 4 solution and Ca(NO 3 ) 2 Mix quickly; then pour the mixed solution into the ultrasonic microwave reactor;

[0060] (c) Simultaneously turn on the ultrasonic microwave instrument to react for a certain period of time;

[0061] (d) Centrifuge the reaction solution, wash it twice with deionized water, and wash it twice with ethanol; then directly put it into a freeze dryer and freeze-dry it for 24 hours;

[0062] (e) Put the sample into a muffle furnace and calcinate for 5 hours to obtain mesoporous hydroxyapatite nanoparticles.

[0063] The mesoporous hydroxyapatite nano-particles prepared by the inventi...

Embodiment 1

[0076] Embodiment 1, preparation of mesoporous hydroxyapatite nanoparticles 1

[0077] Weigh 2.36 g of Ca(NO 3 ) 2 and 0.79 g (NH 4 ) 2 HPO 4 (Ca / P (molar ratio) = 1.67), were dissolved in 50mL and 30mL of deionized water, and adjusted with ammonia water (NH 4 ) 2 HPO 4 solution to 10; the above (NH 4 ) 2 HPO 4 The solution was rapidly added Ca(NO 3 ) 2 Mix in the solution; then pour the mixed solution into the ultrasonic microwave reactor, turn on the ultrasonic microwave instrument at the same time, set the power of ultrasonic and microwave to 200w, and react at 60°C for 30min. Then the reaction solution was centrifuged to remove the supernatant, and the obtained precipitate was washed twice with deionized water and twice with ethanol; then it was directly placed in a freeze dryer for 24 hours; finally, the sample was placed in a muffle furnace for calcination for 5 hours , to obtain mesoporous hydroxyapatite nanoparticles.

[0078] The obtained mesoporous mater...

Embodiment 2

[0080] Embodiment 2, preparation 2 of mesoporous hydroxyapatite nanoparticles

[0081] Weigh 2.72 g of CaSO 4 and 1.38 g NH 4 h 2 PO 4 , respectively dissolved in 50mL and 30mL of deionized water, and adjusted NH with ammonia water 4 h 2 PO 4 solution to pH9.5; the above NH 4 h 2 PO 4 The solution was rapidly added with CaSO under stirring 4Mix in the solution; then pour the mixed solution into the ultrasonic microwave reactor, turn on the ultrasonic microwave instrument at the same time, set the power of ultrasonic and microwave to 50w and 200w respectively, and react at 60°C for 30min. Then the reaction solution was centrifuged to remove the supernatant, and the obtained precipitate was washed twice with deionized water and twice with ethanol; then it was directly placed in a freeze dryer for 24 hours; finally, the sample was placed in a muffle furnace for calcination for 5 hours , to obtain mesoporous hydroxyapatite nanoparticles.

[0082] The obtained mesoporous...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
pore sizeaaaaaaaaaa
specific surface areaaaaaaaaaaa
Login to View More

Abstract

The invention relates to mesoporous hydroxyapatite nonoparticles prepared by a microwave-ultrasonic method, and an application thereof. Inventors of the invention are engaged in developing novel methods for synthesizing mesoporous hydroxyapatite (MHAPN), and provide technical improvements for synthesizing the MHAPN by employing the microwave-ultrasonic method. In the method provided by the invention, no emulsifying agent or structure-directing agent is needed when the MHAPN is synthesized; and the synthesized MHAPN has good dispersibility, relatively good controlled-release effect for medicine and significant antineoplastic activity.

Description

technical field [0001] The invention belongs to the field of materials science; more specifically, the invention relates to a novel mesoporous hydroxyapatite nanoparticle, its preparation method and application. Background technique [0002] Hydroxyapatite (HAP) is the main inorganic component of animal and human bones. It has good biological activity and biocompatibility. In recent years, nano-hydroxyapatite has been widely used in bone tissue repair and drug controllable released, showing certain clinical application prospects [Itoh S and Shinomiya K, et al.J Biomed Mater Res A, 2001, 54(3): 445-453; Takeyama Hand Mohri N, Anticancer Res., 2006, 26(6B) : 4603-4606], some research results have been commercialized. In recent years, with the continuous deepening of research and understanding, it has been found that nano-HAP has unique anti-tumor activity (Liu Z and Tang SL, World J. Gastroenterol., 2003, 9 (9): 1968-1971; Zhu SH and Zhou KC, J. Nanopart. Res., 2004, 6: 307-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00A61K47/02A61P35/00
Inventor 刘昌胜袁媛钱江潮甘琪梁桐
Owner EAST CHINA UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com