Method for preparing mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of template method

A technology of mesoporous hydroxyapatite and high specific surface area, applied in nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the problems of uneven pore size distribution and small surface area, and achieve drug loading The effect of large amount, large specific surface area and simple preparation process

Active Publication Date: 2014-12-10
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, domestic and foreign scholars have prepared porous hydroxyapatite by hydrothermal method. The me

Method used

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  • Method for preparing mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of template method
  • Method for preparing mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of template method
  • Method for preparing mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of template method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of the mesoporous hydroxyapatite nanoparticles provided in this embodiment is carried out in the following steps:

[0029] 1. Dissolve 2.68g of F127 and 17.67g of calcium pantothenate monohydrate in 100g of deionized water, stir vigorously for 2 hours to obtain a clear emulsion; add 12ml of mesitylene solution to the above mixed solution, and stir while adding After the dropwise addition, the mixed solution was stirred for 6 hours.

[0030] Two, the 5.52g K 2 HPO 4 ·3H 2 O was dissolved in 66g of deionized water, stirred and dissolved, and NH 3 ·H 2 O adjusts the pH to 11.

[0031] 3. Use a separatory funnel to mix 0.35mol / L of K 2 HPO 4 The solution was slowly added dropwise into the mixed solution of F127-calcium pantothenate monohydrate, and stirred evenly. After the dropwise addition, the mixed solution was heated to 90° C. in a water bath, and refluxed for 24 hours.

[0032] 4. After the above-mentioned reacted solution is cooled,...

Embodiment 2

[0041] The preparation method of the mesoporous hydroxyapatite nanoparticles provided in this embodiment is carried out in the following steps:

[0042] 1. Dissolve 3.35g of F127 and 22.43g of calcium pantothenate monohydrate in 200g of deionized water, stir vigorously for 3 hours to obtain a clear emulsion; add 16ml of mesitylene solution to the above mixed solution, and stir while adding After the dropwise addition, the mixed solution was stirred for 8 hours.

[0043] Two, the 7.13g K 2 HPO 4 ·3H 2 O was dissolved in 130 g of deionized water, stirred magnetically, and then dissolved with NH 3 ·H 2 O adjusts the pH to 13.

[0044] 3. Use a separatory funnel to mix 0.30mol / L of K 2 HPO 4 The solution was slowly added dropwise to the mixed solution of F127-calcium pantothenate monohydrate, and stirred evenly. After the dropwise addition, the mixed solution was heated to 95° C. in a water bath and refluxed for 28 hours.

[0045] 4. Suction filter the above-mentioned re...

Embodiment 3

[0049] The preparation method of the mesoporous hydroxyapatite nanoparticles provided in this embodiment is carried out in the following steps:

[0050] 1. Dissolve 3.92g of F127 and 26.62g of calcium pantothenate monohydrate in 250g of deionized water and stir vigorously for 4 hours to obtain a clear emulsion; add 22ml of mesitylene solution to the above mixed solution and stir while adding After the dropwise addition, the mixed solution was stirred for 10 hours.

[0051] Two, the 11.26g K 2 HPO 4 ·3H 2 O was dissolved in 130 g of deionized water, stirred magnetically, and then dissolved with NH 3 ·H 2 O adjusts the pH to 12.

[0052] 3. Use a separatory funnel to mix 0.38mol / L of K 2 HPO 4 The solution was slowly added dropwise into the mixed solution of F127-calcium pantothenate monohydrate, and stirred evenly. After the dropwise addition, the mixed solution was heated to 98° C. in a water bath, and refluxed for 32 hours.

[0053] 4. After the above-mentioned re...

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Abstract

The invention discloses a method for preparing a mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of a template method. The method comprises the following steps: firstly, mixing calcium pantothenate, F123 and a certain amount of sym-trimethylbenzene to prepare an emulsion and then dropwise adding a phosphate solution with a certain pH value into the emulsion, heating in a water bath, carrying out reflux reaction and filtering to obtain a precipitate and finally calcining the precipitate in a muffle furnace to remove a template to obtain the hydroxyapatite nanometer particle with a mesoporous structure. The mesoporous hydroxyapatite prepared by the method disclosed by the invention has the characteristics of high specific surface area, large drug loading amount and uniform pore size distribution and is distributed in a spherical nanometer state (the size is less than 100nm). The mesoporous hydroxyapatite serving as a drug carrier can well penetrate through blood vessels and cell walls to reach diseased cells. The entire preparation process is simple and the mesoporous hydroxyapatite can be produced in a large scale.

Description

technical field [0001] The invention relates to a preparation method of mesoporous hydroxyapatite nanoparticles. Background technique [0002] Hydroxyapatite (HAp for short), its chemical formula is Ca 10 (PO 4 ) 6 (OH) 2 , is the main inorganic component of hard tissues in mammals, very close to natural apatite mineral structure, belongs to the hexagonal crystal system, accounts for about 77% in human bones, and as high as 97% in dentary bones. Mainly inorganic ingredients. [0003] As the main component of natural bone, hydroxyapatite has good biocompatibility and high biological activity. Because it contains calcium and phosphorus elements necessary for human tissues, after implantation in the body, under the action of body fluid, Calcium and phosphorus elements will dissociate from the surface of the material, gradually absorbed by body tissues, and chemically bond with human bone tissue, which is osteoconductive, induces bone cell growth, and finally part or all is...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00
Inventor 黄玉东李大龙贺金梅吴亚东王芳程玮璐
Owner HARBIN INST OF TECH
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