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Preparation method of amphiphilic monodisperse hydroxyapatite monocrystal nanorod

A technology of hydroxyapatite and single crystal nanometer, which is applied in the direction of nanotechnology, chemical instruments and methods, phosphorus compounds, etc., can solve the problems of poor shape size, poor shape controllability, single surface characteristics of nano HA, etc. Achieve the effects of good process repeatability, stable product quality and good application prospects

Active Publication Date: 2012-06-13
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still some obvious deficiencies in the synthesis: 1) The process is more complicated: the operation process of most synthetic nano-HA is relatively complicated; 2) The controllability of the shape is poor: the shape size and uniformity of the nano-HA are generally controlled. 3) The cost of additives used in many experiments is relatively high, and some are also toxic, and it is difficult to recycle waste liquid; 4) The synthesized nano-HA only has a single surface characteristic (hydrophilic or hydrophilic). Oily), often undergoes secondary surface modification due to changes in application, and there is no report of amphiphilic nano-HA
Of course, some synthetic experiments have also overcome the individual problems in the above defects, but they have not been able to effectively solve all of them reasonably.

Method used

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  • Preparation method of amphiphilic monodisperse hydroxyapatite monocrystal nanorod
  • Preparation method of amphiphilic monodisperse hydroxyapatite monocrystal nanorod
  • Preparation method of amphiphilic monodisperse hydroxyapatite monocrystal nanorod

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Effect test

Embodiment 1

[0026] Step 1: Add 8mL of 0.28M calcium nitrate aqueous solution, 8mL of 0.16M sodium phosphate aqueous solution, 0.5g of 2-hydroxypropyl-β-cyclodextrin, 16mL of absolute ethanol and 4mL of oleic acid into 50mL of polytetrafluoroethylene In the vinyl fluoride hydrothermal reaction kettle, stir well at room temperature.

[0027] Step 2: Seal the reactor in Step 1, and react at 150° C. for 10 h. Then cool naturally to room temperature, open the reaction kettle, and wash with absolute ethanol, cyclohexane and water in sequence to obtain the final reaction product. The product was identified as hydroxyapatite by X-ray powder diffraction, and the results were as follows: figure 1 Shown; The prepared product can be dispersed in the dispersion liquid of different polarities simultaneously ( figure 2 ); product morphology can be detected by transmission electron microscopy, such as image 3 The diameter distribution of the nanorods prepared as shown is 8~12nm, and the length is be...

Embodiment 2

[0029] Step 1: Add 8mL of 0.28M calcium nitrate aqueous solution, 8mL of 0.16M sodium hydrogen phosphate aqueous solution, 0.25g of 2-hydroxypropyl-β-cyclodextrin, 16mL of absolute ethanol and 2mL of oleic acid into 50mL of poly In the tetrafluoroethylene hydrothermal reaction kettle, stir well at room temperature.

[0030] Step 2: Seal the reactor in Step 1, and react at 180° C. for 5 hours. Then cool naturally to room temperature, open the reaction kettle, and wash with absolute ethanol, chloroform and water in sequence to obtain amphiphilic monodisperse hydroxyapatite single crystal nanorods.

Embodiment 3

[0032] Step 1: Add 8mL of 0.28M calcium nitrate aqueous solution, 8mL of 0.16M sodium dihydrogen phosphate aqueous solution, 0.5g of 2-hydroxypropyl-β-cyclodextrin, 16mL of absolute ethanol and 6mL of oleic acid into 50mL of In a polytetrafluoroethylene hydrothermal reaction kettle, stir well at room temperature.

[0033] Step 2: Seal the reactor in Step 1, and react at 120° C. for 15 hours. Then cool naturally to room temperature, open the reaction kettle, and wash with absolute ethanol, chloroform and water in sequence to obtain amphiphilic monodisperse hydroxyapatite single crystal nanorods.

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Abstract

The invention relates to a preparation method of an amphiphilic monodisperse hydroxyapatite (HA) monocrystal nanorod. The method comprises: taking the mole ratio 1.67 of calcium element to phosphor element as a reference, taking a soluble calcium salt and a phosphate as the raw materials, adopting a surfactant 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) for assisting, and employing ethanol and oleic acid as the auxiliary agents, subjecting the materials to reaction in an airtight system for synthesizing a nano-hydroxyapatite particle with good amphiphilic surface properties by controlling the reaction temperature, the reaction time and the raw material ratio, thus obtaining a monodisperse hydroxyapatite monocrystal nanorod with good amphipathy. The nanorod has a diameter of 8-12nm and a length of 150nm-250nm. The hydroxyapatite nanoparticle prepared in the invention can be applied in material outer coatings, degradable artificial bones, bone cement and other biomedical materials, and is an amphiphilic monodisperse hydroxyapatite monocrystal nanorod with excellent biological performance and physico-chemical performance, thus boasting good application prospects.

Description

technical field [0001] The invention relates to a method for preparing monodisperse one-dimensional nanomaterials, in particular to amphiphilic monodisperse hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) liquid phase synthesis of single crystal nanorods. Background technique [0002] For bone damage, if the degree is relatively slight, it can be healed through the self-repair of the body's bone. However, bone defects caused by severe trauma, bone tumors, osteomyelitis and other reasons are very common. If the damage or loss is large In this case, it is necessary to use bone repair materials to fill or transplant the repair. [0003] Compared with the mineral phase of natural bone, due to the similarity in chemical structure, hydroxyapatite (HA) has good biological activity, biocompatibility, osteoinductive osteogenesis, and is one of the few energy It is one of the materials that form a strong chemical bond with the bone in the body, making it an important part of the fra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 范代娣惠俊峰严建亚
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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