Preparation method of poly (lactic acid-glycolic acid)/hydroxyapatite nanofiber compound bracket for bone repair

A technology of hydroxyapatite and glycolic acid, applied in nanostructure manufacturing, phosphorus compounds, nanotechnology and other directions, can solve the problems of difficult to promote the expression of normal activity of osteoblasts, difficult to obtain cell active sites, etc.
CN101693126AInactive Publication Date: 2010-04-14ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2010-04-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a poly (lactic acid-glycolic acid) / hydroxyapatite nanofiber compound bracket for bone repair, which comprises the following steps: adding hydroxyapatite nanoparticles into a mixed solvent of tetrahydrofuran and dimethylformamide, and then, adding poly (lactic acid-glycolic acid) to obtain a mixed solution of the hydroxyapatite and the poly (lactic acid-glycolic acid); carrying out electrostatic spinning on the mixed solution; and obtaining the poly (lactic acid-glycolic acid) / hydroxyapatite nanofiber compound bracket for bone repair. The invention has simple and convenient preparation method and wide material sources, simulates the composition and the structure of natural bones of human bodies, introduces the bioactive ceramic material hydroxyapatite into a degradable poly (lactic acid-glycolic acid) substrate to form a compound nanofiber bracket, has the advantages of good biocompatibility, excellent comprehensive performance, convenient use and the like, can effectively promote the adhesion, growth and function expression of bone cells and meet the biological requirements of the bone tissue engineering.
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Description

technical field

[0001] The invention relates to a preparation method of poly(lactic acid-glycolic acid) / hydroxyapatite nanofiber composite scaffold for bone repair. Background technique

[0002] Bone is a general term for a group of biomineral materials, mainly developed in vertebrates. Although the structure and composition of each type of bone vary slightly, they all have a common feature: they are mainly composed of type I collagen fibers, carboxyhydroxyapatite and water. Bone is one of the most complex biomineralization systems and the most typical natural organic-inorganic composite material. The carbab hydroxyapatite crystals in bone are all plate-shaped, with an average length and width of 50nm and 25nm, respectively; the crystal thickness is extremely thin and very consistent, generally 1.5nm to 4.0nm. The main organic phase of bone is collagen fibers, and there are also a small amount of bone sialoprotein, chondroitin sulfate, lipids, peptides, etc. The procollag...

Claims

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