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Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof

A nanoparticle and biologically active technology, applied in the field of biomedical materials, can solve the problems of not having hydroxyapatite and shape memory type, and achieve the effect of large application and promotion value, low production cost and excellent dispersion effect

Inactive Publication Date: 2019-05-03
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the disadvantages and deficiencies of the scaffold materials based on 3D printing high internal phase emulsions in the above-mentioned prior art that do not have hydroxyapatite and shape memory type, the primary purpose of the present invention is to provide a shape memory type bioactive nanoparticle / biological Preparation method of degradable polyester composite multi-scale porous bioscaffold

Method used

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  • Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof
  • Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof
  • Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0054] (1) In an ice-water bath, prepare 4 parts by volume of dichloromethane suspension by ultrasonication for 30 minutes, that is, the oil phase, in which the biodegradable polylactic acid-trimethylene carbonate copolymer (molecular weight is 5.2 × 10 4 g / mol, wherein the molar ratio of lactic acid and trimethylene carbonate is 80:20), the mass volume fraction of hydrophobic hydroxyapatite and hydrophobic nano silicon dioxide is 9w / v%, 7.5w / v%, 2w / v%;

[0055] (2) Add 12 parts by volume of distilled water in batches to the oil phase obtained in step (1), mix and emulsify with a vortex mixer at 3000r / min for 12min to obtain a water-in-oil type high internal phase emulsion;

[0056] (3) Use the high internal phase emulsion obtained in step (2) as ink, put it into the extrusion 3D printer syringe equipped with 18G micro-needles, and apply pressure to the syringe with a pressure of 0.05MPa air pump to control the printing speed 20mm / s, according to the preset rectangular parall...

Embodiment 2

[0060] (1) In an ice-water bath, prepare 4 parts by volume of dichloromethane suspension, that is, the oil phase, by ultrasonication for 30 minutes, wherein the biodegradable polylactic acid-trimethylene carbonate copolymer (molecular weight is 5 × 10 4 g / mol, wherein the molar ratio of lactic acid and trimethylene carbonate is 70:30), the mass volume fraction of hydrophobic hydroxyapatite and hydrophobic nano silicon dioxide is 9w / v%, 9w / v%, 1w / v%;

[0061] (2) Add 13 parts by volume of distilled water in batches to the oil phase obtained in step (1), mix and emulsify with a vortex mixer at 2500r / min for 15min to obtain a water-in-oil type high internal phase emulsion;

[0062] (3) Use the high internal phase emulsion obtained in step (2) as ink, put it into the extrusion 3D printer syringe equipped with 20G micro-needles, and apply pressure to the syringe with a pressure of 0.02MPa air pump to control the printing speed 20mm / s, according to the preset cylindrical (Φ30mm×7m...

Embodiment 3

[0065] (1) In an ice-water bath, prepare 4 parts by volume of dichloromethane suspension by ultrasonication for 30 minutes, that is, the oil phase, in which the biodegradable polylactic acid-glycolic acid-trimethylene carbonate copolymer (molecular weight is 3× 10 4 g / mol, wherein the molar ratio of lactic acid, glycolic acid and trimethylene carbonate is 80:10:10), the mass volume fraction of hydrophobic hydroxyapatite and ethyl cellulose is 4w / v%, 9w / v %, 2w / v%;

[0066] (2) Add 12 parts by volume of distilled water in batches to the oil phase obtained in step (1), mix and emulsify with a vortex mixer at 2500r / min for 15 minutes to obtain a water-in-oil type high internal phase emulsion;

[0067] (3) Use the high internal phase emulsion obtained in step (2) as ink, put it into an extrusion 3D printer syringe equipped with a 21G microneedle, and use a 0.04MPa air pump to apply pressure to the syringe to control the printing speed 25mm / s, according to the preset scaffold cub...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a shape memory-type bioactive nano particle / biodegradable polyester composite multi-scale pore biological scaffold and a preparation method thereof. The method of the invention comprises the steps of: adding biodegradable shape memory polyester, hydroxyapatite nano particles and a rheology modifier to an organic solvent, and performing ultrasonic effect to obtain an oil phase; adding water to the oil phase, and performing emulsification to form water-in-oil high-internal phase emulsion; and taking the high-internal phase emulsion as an ink, adopting extrusion-type 3D printing to obtain a three-dimensional porous emulsion scaffold, and evaporating the solvent to obtain the biological scaffold. The scaffold contains a multi-scale pore structure, in which controllable micropores and macropores coexist. The porosity is higher than 85%, and the pore structures are connected to one another, so that the scaffold has excellent biocompatibility, biodegradability, biological activity, shape memory effect, and drug growth / factor loading and release, and can be applied in the field of drug controlled release and the field of tissue engineering scaffolds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a shape-memory bioactive nanoparticle / biodegradable polyester composite multi-scale porous biological scaffold and a preparation method thereof. Background technique [0002] Bone damage or loss caused by various reasons such as trauma, infection, tumor and birth defects is a daily treatment problem in orthopedic clinics. Therefore, effective repair of damaged or missing bone tissue has become a research hotspot in the field of biomedicine . Filling bone defects with organized porous biological scaffolds based on the concept of bionics, that is, bone tissue engineering, is an ideal way to restore bone structure and function. In bone tissue engineering, porous bioscaffolds not only provide an extracellular matrix-like environment for cell adhesion, growth, proliferation, and differentiation, but also act as a temporary three-dimensional functional templat...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L27/56A61L27/58
Inventor 胡洋王景光杨卓鸿周武艺卢梁美张芙宁
Owner SOUTH CHINA AGRI UNIV
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