Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof

A nanoparticle and biologically active technology, applied in the field of biomedical materials, can solve the problems of not having hydroxyapatite and shape memory type, and achieve the effect of large application and promotion value, low production cost and excellent dispersion effect
CN109701084AInactive Publication Date: 2019-05-03SOUTH CHINA AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2019-05-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a shape memory-type bioactive nano particle / biodegradable polyester composite multi-scale pore biological scaffold and a preparation method thereof. The method of the invention comprises the steps of: adding biodegradable shape memory polyester, hydroxyapatite nano particles and a rheology modifier to an organic solvent, and performing ultrasonic effect to obtain an oil phase; adding water to the oil phase, and performing emulsification to form water-in-oil high-internal phase emulsion; and taking the high-internal phase emulsion as an ink, adopting extrusion-type 3D printing to obtain a three-dimensional porous emulsion scaffold, and evaporating the solvent to obtain the biological scaffold. The scaffold contains a multi-scale pore structure, in which controllable micropores and macropores coexist. The porosity is higher than 85%, and the pore structures are connected to one another, so that the scaffold has excellent biocompatibility, biodegradability, biological activity, shape memory effect, and drug growth / factor loading and release, and can be applied in the field of drug controlled release and the field of tissue engineering scaffolds.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a shape-memory bioactive nanoparticle / biodegradable polyester composite multi-scale porous biological scaffold and a preparation method thereof. Background technique

[0002] Bone damage or loss caused by various reasons such as trauma, infection, tumor and birth defects is a daily treatment problem in orthopedic clinics. Therefore, effective repair of damaged or missing bone tissue has become a research hotspot in the field of biomedicine . Filling bone defects with organized porous biological scaffolds based on the concept of bionics, that is, bone tissue engineering, is an ideal way to restore bone structure and function. In bone tissue engineering, porous bioscaffolds not only provide an extracellular matrix-like environment for cell adhesion, growth, proliferation, and differentiation, but also act as a temporary three-dimensional functional templat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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