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Composite biological medical materials of nano-hydroxy-apatite/silicon rubber and its preparation

A technology of nano-hydroxyapatite and biomedical materials, applied in medical science, prosthesis, etc., can solve the problems of limited mechanical properties and comprehensive biological properties, easy agglomeration, high surface activity of hydroxyapatite, and achieve comprehensive performance Excellent, uniform mixing and distribution effect

Inactive Publication Date: 2007-01-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high surface activity of hydroxyapatite, it is easy to agglomerate, and it is difficult to form a composite material with uniform distribution of hydroxyapatite by mechanically blending hydroxyapatite powder and polymers. Improvement of comprehensive performance including performance and biological performance

Method used

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  • Composite biological medical materials of nano-hydroxy-apatite/silicon rubber and its preparation
  • Composite biological medical materials of nano-hydroxy-apatite/silicon rubber and its preparation
  • Composite biological medical materials of nano-hydroxy-apatite/silicon rubber and its preparation

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Experimental program
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Effect test

Embodiment 1

[0029] (1) Preparation of nano-hydroxyapatite slurry: According to the method reported in the aforementioned literature, calcium nitrate and diammonium hydrogen phosphate are reacted at 70 ° C, and the pH value is adjusted to 10-12 with ammonia water to obtain hydroxyapatite After the initial deposit, rinse thoroughly with deionized water. The initial sediment was hydrothermally treated at 140° C. and 0.3 MPa for 2 hours, and then part of the water was removed by centrifugation to obtain a nano-hydroxyapatite component slurry with a solid weight of 30%.

[0030] (2) With hydroxyapatite weight 2% vinyltriethoxysilane 60g as silane coupling agent, add in the 2kg ethanol-water solution that has adjusted pH value to 4.5, ethanol content (weight) 20% with acetic acid, It is formulated as a treatment solution for surface modification treatment of nano-hydroxyapatite components.

[0031] (3) Surface modification treatment on the nano-hydroxyapatite component: add the above-mentioned...

Embodiment 2

[0035] Operation mode and condition are the same as embodiment 1.

[0036] Get nano-hydroxyapatite composition and be 4.5kg slurry (solid matter weight content is 40%), take the vinyl triethoxysilane of 1% by weight of hydroxyapatite composition as silane coupling agent, adjust with acetic acid Surface modification treatment was carried out at 45° C. in 6.7 kg of water-ethanol solution with a pH value of 3.5 and an ethanol content (weight) of 30%. The slurry after the surface modification treatment was washed with deionized water, and mixed with 10.5 kg of methyl vinyl silica raw rubber (the weight ratio of nano-hydroxyapatite to methyl vinyl silica raw rubber was 3:7) in rubber mixing After kneading in the machine at room temperature, the mixed rubber was heated in an oven at 120°C for 1 hour. Add 63 g of vulcanizing agent 2,5-dimethyl-2,5-di-tert-butylperoxyhexane in the proportion of 0.6% of raw rubber weight in the mixed rubber to vulcanize, and obtain nano-hydroxyapatite...

Embodiment 3

[0038] Operation mode and condition are the same as embodiment 1.

[0039] Get nano-hydroxyapatite composition and be 6kg slurry 20kg, take hydroxyapatite weight 4wt% vinyltriethoxysilane 240g as silane coupling agent, add the 4kg ethanol that has adjusted pH value to 5.5 with acetic acid- In the aqueous solution, stir at 55°C for surface modification treatment. After the modified slurry was washed with deionized water, it was mixed with 9 kg of methyl vinyl silicon raw rubber (the weight ratio of nano-hydroxyapatite to methyl vinyl silicon raw rubber was 4:6) in the rubber mixer After medium mixing, 135 g of 2,5-dimethyl-2,5-di-tert-butylperoxyhexane curing agent was added at a ratio of 1.5% by weight of the raw rubber in the mixed rubber for vulcanization treatment. A nano-hydroxyapatite / silicone rubber composite biomedical material with a weight ratio of nano-hydroxyapatite and silicone rubber of 4:6 is obtained.

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Abstract

A nano-class biomedical hydroxyapatite-silicon rubber material is prepared through dissolving silane coupling agent in water-alcohol solution, regulating pH value to 3.5-5.5, mixing with hydroxyapatite nanoparticles while stirring for surface modifying, washing the solid with deionized water, proportionally mixing it with raw silicon rubber, drying, and thermal sulfurizing.

Description

technical field [0001] The invention relates to a nano-hydroxyapatite / silicone rubber composite biomedical material and a preparation method thereof. Background technique [0002] Silicone rubber is an inert biomedical material with stable physical and chemical properties. It has been used clinically as an implant for decades. It has been widely used in cosmetic plastic surgery, such as artificial nose bridge, artificial mandible, artificial skull Wait. However, after the silicone rubber is implanted into the human body, it cannot be combined with the autologous tissue, and can only be surrounded by a fibrous envelope. The position of the implant is easy to move, and in severe cases, the implantation operation will fail. The practice of long-term use has also found that in a small number of cases, the silicone rubber occasionally has problems such as rejection and infection after it is implanted in the human body. Therefore, it is necessary to modify the silicone rubber to ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/50
Inventor 李玉宝文季秋
Owner SICHUAN UNIV
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